Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Wakis
Synonyms :
pitolisant
Class :
CNS Stimulant agents and Histamine (H3) receptor blockers
Brand Name :
Wakis
Synonyms :
pitolisant
Class :
CNS Stimulant agents and Histamine (H3) receptor blockers
Dosage Forms & Strengths
Tablet, Oral:
4.45 mg
17.8 mg
18 mg
5 mg
20 mg
8.9
mg
Orally
once a day for 1 week and increase to 17.8 mg/day for another week (Maximum dose: 35.6 mg/day)
Dosage Forms & Strengths
Tablet, Oral:
100 mg
Attention Deficit Hyperactivity Disorder (ADHD)
Children > 6 years to 13 years::
For weight <30kg: 200 mg to 340 mg once a day
For weight >30kg: 300 to 425 mg once a day
Refer to adult dosing
Initiate at lower doses
pitolisant: they may diminish the serum concentration of hormonal contraceptives
pitolisant: they may diminish the serum concentration of hormonal contraceptives
pitolisant: they may diminish the serum concentration of hormonal contraceptives
pitolisant: they may diminish the serum concentration of hormonal contraceptives
pitolisant: they may enhance the serum concentration of CYP2D6 Inhibitors
pitolisant: they may enhance the serum concentration of CYP2D6 Inhibitors
pitolisant: they may enhance the serum concentration of CYP2D6 Inhibitors
pitolisant: they may enhance the serum concentration of CYP2D6 Inhibitors
pitolisant: they may enhance the serum concentration of CYP2D6 Inhibitors
pitolisant: they may decrease the therapeutic effect of antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines
The Therapeutic efficacy of pitolisant may be reduced by antihistamines
dexchlorpheniramine, dextromethorphan, and phenylephrine
The Therapeutic efficacy of pitolisant may be reduced by antihistamines
The Therapeutic efficacy of pitolisant may be reduced by antihistamines
The Therapeutic efficacy of pitolisant may be reduced by antihistamines
The Therapeutic efficacy of pitolisant may be reduced by antihistamines
pitolisant: they may decrease the therapeutic effect of antihistamines, antiemetics
pitolisant: they may decrease the therapeutic effect of antihistamines, antiemetics
pitolisant: they may increase the CNS depressant effect of CNS Depressants
pitolisant: they may increase the CNS depressant effect of CNS Depressants
pitolisant: they may increase the CNS depressant effect of CNS Depressants
pitolisant: they may increase the CNS depressant effect of CNS Depressants
pitolisant: they may increase the CNS depressant effect of CNS Depressants
QTc interval increases on taking pitolisant and lenvatinib together. Avoid or take an alternate drug
CYP3A strong enhancers of the small intestine may reduce the bioavailability of pitolisant
may decrease the therapeutic effect of antihistamines
the effect of pitolisant may be reduced
When pitolisant is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
the effect of pitolisant is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
it decreases the concentration of hormonal contraceptives in serum
they decrease the concentration of active metabolites of infigratinib in the serum
Frequency defined:
>10%
Headache
Decreased appetite
Abdominal pain
1% to 10%
Chest pain
Palpitations
Tachycardia
Vasodilation
Edema
Nervousness
Anxiety
Dizziness
Insomnia
Depression
Vasodilation
Drowsiness
Agitation
Vertigo
Hypertonia
Chills
Weight loss
Increased thirst
Anorexia
Hepatic insufficiency
Back pain
Tremor
Visual disturbance
Rhinitis
Pharyngitis
Epistaxis
Frequency not defined:
Increased serum alkaline phosphatase
Increased gamma-glutamyl transferase
Postmarketing
Angioedema
Hepatotoxicity
Aggressive behavior
Agranulocytosis
Delusion
Hallucination
Psychosis
Skin rash
Suicidal ideation
Pregnancy consideration: Studies reported major congenital malformations following in-utero exposure to pitolisant.
Lactation: Pitolisant can be excreted in breast milk.
Pregnancy category:
Patient information leaflet
Generic Name: Pitolisant
Pronounced: pitolisant
Why do we use pitolisant?
Pitolisant is used to treat sleep apnea, narcolepsy, and other conditions related to daytime sleepiness.
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