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Brand Name :
Sterapred DS, Deltasone, Sterapred, Rayos, and Prednisone Intensol
Synonyms :
prednisone
Class :
Corticosteroids
Brand Name :
Sterapred DS, Deltasone, Sterapred, Rayos, and Prednisone Intensol
Synonyms :
prednisone
Class :
Corticosteroids
Dosage Forms & Strengths
Oral solution
5mg
Tablet
1mg
2.5mg
5mg
10mg
20mg
50mg
Tablet-delayed release
1mg
2mg
5mg
Glucocorticoid Responsive Condition
5 - 60
mg
Orally
once a day
40 - 60
mg
Orally
once a day
3 - 10
days
40-60 mg/day orally for 3-10 days
40 - 60
mg
orally
daily
40 - 60
mg
orally
daily
Idiopathic Thrombocytopenic Purpura (ITP)
1-2 mg/kg/day orally
Dose Tapering
1-Day: 10 mg orally before breakfast, 5 mg orally after lunch, 5 mg orally after dinner, and 10 mg orally at bedtime
2-Day: 5 mg orally before breakfast,5mg orally after lunch, 5mg orally after dinner, and 10 mg orally at bedtime
3-Day: 5 mg orally before breakfast,5mg orally after lunch, 5mg orally after dinner, and 5mg at bedtime
4-Day: 5 mg orally before breakfast, 5mg orally after lunch, and 5mg at bedtime
5-Day: 5 mg orally before breakfast and 5mg at bedtime
6-Day: 5 mg orally before breakfast
≤10 mg/day orally Immediate release
5 mg/day orally Delayed release
Maintenance: low dose taken at bedtime to decrease morning stiffness with rheumatoid arthritis (RA)
≤10 mg/day orally Immediate release
5 mg/day orally Delayed release
Maintenance: low dose taken at bedtime to decrease morning stiffness with rheumatoid arthritis (RA)
Advanced Pulmonary Extrapulmonary Tuberculosis
40-60 mg/day orally tapered 4-8 weeks
Advanced Pulmonary Extrapulmonary Tuberculosis
40-60 mg/day orally tapered 4-8 weeks
60 mg/day orally 1 week; next 40 mg/day orally 1 week; then 30 mg/day orally 2 weeks; following 20 mg/Day; if given with a combo of azathioprine, decrease half of this dose
NIH guidelines recommend If dexamethasone is unavailable, use alternative glucocorticoids, prednisone
40 mg orally every day 10 days (off-label)
40-60 mg orally every day 7-28 days (off-label)
Dosage Forms & Strengths
Oral solution, concentrate
5mg
Tablet
1mg
2.5mg
5mg
10mg
20mg
50mg
Tablet, delayed release
1mg
2mg
5mg
Age: <12 years
1-2 mg/kg orally daily or divided every 12 hours 3-10 days
Age: ≥12 years
40-60 mg/kg orally daily or divided every 12 hours 3-10 days
2 mg/kg orally daily and do not exceed 80 mg/day
When prednisone is used in combination with rabies vaccine, this leads to a reduction in the rabies vaccine effects through the process of pharmacodynamic antagonism
when prednisone is used in combination with diphtheria & tetanus toxoids, this leads to a reduction in the effects of diphtheria & tetanus toxoids through pharmacodynamic antagonism
the effect of nivolumab decreases on interacting with prednisone
CYP3A strong enhancers of the small intestine may reduce the bioavailability of prednisone
prednisone: they may diminish the serum concentration of CYP3A4 Inducers
prednisone: they may diminish the serum concentration of CYP3A4 Inducers
prednisone: they may diminish the serum concentration of CYP3A4 Inducers
prednisone: they may diminish the serum concentration of CYP3A4 Inducers
prednisone: they may diminish the serum concentration of CYP3A4 Inducers
When prednisone is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
it decreases the effect or level of finasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
it decreases the effect or level of dutasteride by altering the intestinal/hepatic enzyme CYP3A4 metabolism
Action and spectrum:
Action:
Binding to Glucocorticoid Receptors: Specifically, prednisolone exhibit affinity for glucocorticoid receptors which are present in the cytoplasm of target tissues.
Translocation to the Nucleus: The receptor-steroid complex relocates within the cell to the nucleus where it forms a complex with glucocorticoid response elements (GREs) in the DNA.
Gene Regulation: This binding results in the increased expression of genes that generate antiinflammatory molecules while reducing those that create proinflammatory molecules.
Spectrum:
Autoimmune Diseases: Like rheumatoid arthritis, lupus, and multiple sclerosis.
Allergic Reactions: Such as life-threatening anaphylaxis and asthma.
Frequency Not Defined
Acne
Allergic dermatitis
Anaphylaxis
Arrhythmias
Congestive heart failure
Fat embolism
Pulmonary edema
Dry scalp
Contraindication/Caution:
Contraindication:
Known Hypersensitivity
Uncontrolled Infections
Caution
Hypertension and Cardiovascular Disease
Gastrointestinal Issues
Pregnancy and Lactation
Ophthalmic Issues
Pregnancy/Lactation
Pregnancy warnings:
Pregnancy Category: N/A
Lactation: known if distributed into breast milk, avoid
Pregnancy Categories:
Pharmacology:
Prednisone is a synthetic glucocorticoid drug.
Pharmacodynamics:
Prednisolone acts as a synthetic glucocorticoid and works by binding to glucocorticoid receptors which are found in the cytoplasm, the receptor leaves the ligand and migrates to the nucleus. This complex binds with glucocorticoid response elements in the DNA to modulate the production of genes associated with inflammation.
Pharmacokinetics:
Absorption
The drug bioavailability is 92%.
The peak plasma time for immediate release formulation is 2 hours and the peak plasma time for delayed release is 6 to 6.5 hour.
Distribution
The drug protein bound is 65 to 91 %.
Metabolism
The drug metabolism occurs in liver.
Excretion and Elimination
The route of excretion is mainly urine.
The half-life of the drug is 2.6 to 3 hours.
Administration:
The drug is taken orally.
Dosage and duration are based on the specific condition, severity, and patient response.
Patient Information Leaflet
Generic Name: prednisone (Rx)
Why do we use prednisone (Rx)?
A corticosteroid drug prednisone is used to treat rheumatoid arthritis, giant cell arthritis, idiopathic thrombocytopenic purpura, and acute asthma.
Prednisone is frequently used to treat autoimmune conditions.
Treatment for severe allergic responses involves its usage.
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