Impact of High-Pillow Sleeping Posture on Intraocular Pressure in Glaucoma
January 28, 2026
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Brand Name :
No Data Available.
Synonyms :
Procainamide
Class :
Antidysrhythmics
Brand Name :
No Data Available.
Synonyms :
Procainamide
Class :
Antidysrhythmics
Dosage Forms & Strengths
Solution
100 mg/ml
500mg/ml
Dosage Forms & Strengths
Solution
100 mg/ml
500mg/ml
It may enhance QTc interval when combined with erythromycin stearate
It may enhance QTc interval when combined with perphenazine
when both drugs are combined, there may be an increase in qtc interval
trimethoprim may increase serum concentrations of procainamide
trilaciclib decreases the efficacy of procainamide
QTc interval is increased both by lenvatinib and procainamide
may increase the QTc prolonging effect
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
It may enhance the risk of adverse reactions when combined with sodium
aminohippuric acid has the potential to increase the serum concentration of procainamide
When procainamide is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Action and Spectrum:
Procainamide blocks sodium channels in the heart, that slows sodium influx during depolarization. It stabilizes neuronal membrane to inhibit ionic fluxes and reduces ectopic heart cell activity to suppress abnormal electrical rhythms.
Adverse reaction:
>10%
Increased antinuclear antibodies
SLE-like syndrome
1-10%
Hypotension
Frequency Not Defined
Arrhythmias
Ataxia
Bitter taste
Myopathy
Chills
Asystole
Heart block
Asthenia
Psychosis
Abdominal pain
Rash
Black box warning:
Proarrhythmic Effects
Blood Dyscrasias
Lupus Erythematosus-Like Syndrome
Contraindications/caution:
Contraindications:
Hypersensitivity
Complete heart block
Cautions:
Cardiac Conditions
Electrolyte Imbalance
Renal Impairment
Liver Disease
Autoimmune Disorders
Pregnancy Warnings:
Pregnancy category: C
Lactation: It crosses into breast milk but discontinue drug and avoid nursing.
Pregnancy categories:
Pharmacology:
Procainamide reduces ectopic pacemaker cell activity to suppress abnormal electrical signals. It shows mild anticholinergic effect which decreased ventricular excitability and increased stimulation threshold in diastolic movement.
Pharmacodynamics:
Procainamide extends their effective refractory period in heart muscle that blocks potassium current. Thus, it reduces sinoatrial node activity to stabilize the heart rhythm.
Pharmacokinetic:
Absorption:
It shows bioavailability up to 75 to 95% and reaches peak plasma in 15 to 60 minutes.
Distribution
It has volume of distribution around 2 L/kg.
Metabolism:
Procainamide is metabolized in the liver with N-acetyltransferase to form N-acetylprocainamide (NAPA).
Excretion and elimination:
It has a moderate half-life of 2.5 to 4.7 hours which allows for infrequent dosing intervals and has renal clearance of 150 to 600 mL/min.
Administration:
It is administered through intravenous and intramuscular route as infusion.
Patient information leaflet:
Generic Name: Procainamide
Why do we use Procainamide?
Procainamide is used in treatment of ventricular arrhythmias and paroxysmal supraventricular tachycardia.
It is also indicated to treat and manage atrial fibrillation or flutter to restore normal heart rate.
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