Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
No Data Available.
Synonyms :
Procainamide
Class :
Antidysrhythmics
Brand Name :
No Data Available.
Synonyms :
Procainamide
Class :
Antidysrhythmics
Dosage Forms & StrengthsÂ
SolutionÂ
100 mg/mlÂ
500mg/ml
Dosage Forms & StrengthsÂ
SolutionÂ
100 mg/mlÂ
500mg/mlÂ
Â
It may enhance QTc interval when combined with erythromycin stearate
It may enhance QTc interval when combined with perphenazine
when both drugs are combined, there may be an increase in qtc interval  
trimethoprim may increase serum concentrations of procainamide
trilaciclib decreases the efficacy of procainamide
QTc interval is increased both by lenvatinib and procainamide
may increase the QTc prolonging effect
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
it increases the effect of neuromuscular blockage of neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
may have an increased neuromuscular-blocking effect when combined with neuromuscular-blocking agents
It may enhance the risk of adverse reactions when combined with sodium
aminohippuric acid has the potential to increase the serum concentration of procainamide
When procainamide is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Action and Spectrum:Â
Procainamide blocks sodium channels in the heart, that slows sodium influx during depolarization. It stabilizes neuronal membrane to inhibit ionic fluxes and reduces ectopic heart cell activity to suppress abnormal electrical rhythms.Â
Adverse reaction:Â
>10%Â
Increased antinuclear antibodiesÂ
SLE-like syndromeÂ
1-10%Â
HypotensionÂ
Frequency Not DefinedÂ
ArrhythmiasÂ
AtaxiaÂ
Bitter tasteÂ
MyopathyÂ
ChillsÂ
AsystoleÂ
Heart blockÂ
AstheniaÂ
PsychosisÂ
Abdominal painÂ
RashÂ
Black box warning:Â
Proarrhythmic EffectsÂ
Blood DyscrasiasÂ
Lupus Erythematosus-Like SyndromeÂ
Contraindications/caution:Â
Contraindications:Â
Hypersensitivity Â
Complete heart blockÂ
Cautions:Â
Cardiac ConditionsÂ
Electrolyte ImbalanceÂ
Renal ImpairmentÂ
Liver DiseaseÂ
Autoimmune DisordersÂ
Pregnancy Warnings:Â
Pregnancy category: CÂ
Lactation: It crosses into breast milk but discontinue drug and avoid nursing.Â
Pregnancy categories:Â
Pharmacology:Â
Procainamide reduces ectopic pacemaker cell activity to suppress abnormal electrical signals. It shows mild anticholinergic effect which decreased ventricular excitability and increased stimulation threshold in diastolic movement.Â
Pharmacodynamics:Â
Procainamide extends their effective refractory period in heart muscle that blocks potassium current. Thus, it reduces sinoatrial node activity to stabilize the heart rhythm.Â
Pharmacokinetic:Â Â
Absorption:Â
It shows bioavailability up to 75 to 95% and reaches peak plasma in 15 to 60 minutes.Â
DistributionÂ
It has volume of distribution around 2 L/kg.Â
Metabolism:Â
Procainamide is metabolized in the liver with N-acetyltransferase to form N-acetylprocainamide (NAPA).Â
Excretion and elimination:Â
It has a moderate half-life of 2.5 to 4.7 hours which allows for infrequent dosing intervals and has renal clearance of 150 to 600 mL/min.Â
Administration:Â
It is administered through intravenous and intramuscular route as infusion.Â
Patient information leaflet:Â
Generic Name: ProcainamideÂ
Why do we use Procainamide?Â
Procainamide is used in treatment of ventricular arrhythmias and paroxysmal supraventricular tachycardia.Â
It is also indicated to treat and manage atrial fibrillation or flutter to restore normal heart rate.Â
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