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Brand Name :
Ecovia
Synonyms :
Remacemide
Class :
Anticonvulsant, NMDA receptor antagonist
Brand Name :
Ecovia
Synonyms :
Remacemide
Class :
Anticonvulsant, NMDA receptor antagonist
Dosage Forms & Strengths
Adult
Tablet
200 mg
300 mg
600 mg
It is a novel drug in the threatment of Huntingtons disease
The recommended daily dosage is 200 mg once a day via oral administration for the duration of 30 months
Dose Adjustments
Limited data is available
Pediatric
Not determined
remacemide may enhance the central nervous system depressant (CNS depressant) activities of baclofen
the CNS depression risk or severity may be increased when benzphetamine is combined with remacemide
when remacemide is combined with benzyl alcohol, the risk or severity of methemoglobinemia may be increased
the serum concentration of bicalutamide can be elevated when combined with remacemide
the central nervous system depressant (CNS depressant) activities of azelastine may be increased when combined with remacemide
when combined with remacemide, the metabolism of azithromycin may decrease.
the therapeutic efficacy of remacemide may be reduced when used in combination with azlocillin
the risk or severity of CNS depression may be increased when remacemide is combined with benperidol
when combined with remacemide, the risk or severity of methemoglobinemia associated with benzocaine may be increased
Action and Spectrum:
Remacemide is a non-competitive NMDA receptor antagonist that inhibits excessive glutamate to prevent toxicity-induced neuronal injury and death.
Adverse reaction
None
Black box warning:
None
Contraindications/caution:
Contraindications:
Hypersensitivity
Cautions:
Renal Impairment
Liver Impairment
Pregnancy and Breastfeeding
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is unknown
Pregnancy categories:
Pharmacology:
Remacemide blocks sodium channels to stabilize neuronal membranes and control epileptic seizures.
Pharmacodynamics:
NMDA receptors regulate synaptic plasticity and excitotoxicity. It protects neurons that blocks receptors and reduces calcium influx.
Pharmacokinetic:
Limited information is available on ADME.
Administration:
It is available in tablet form for oral use.
Patient information leaflet:
Generic Name: Remacemide
Why do we use Remacemide?
Remacemide is an investigational drug used to control seizures in epilepsy.
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