risedronic acid

Action and Spectrum

Actions and Spectrum 

risedronic acid inhibits bone resorption, which is the process by which osteoclasts which means cells that break down bone tissue.  

By binding to hydroxyapatite crystals in bone, which are released during bone resorption, and interfering with osteoclast activity.

Drug Interaction

Adverse Reaction

Frequency not defined  

Diaphyseal femoral fractures  

Severe bone 

Joint or muscle pain  

Upper gastrointestinal mucosa irritation   

Ocular effects  

Hypocalcemia 

Abdominal pain  

Constipation 

Diarrhea 

Dyspepsia  

Nausea 

Vomiting 

Back pain  

Pain in the extremity 

Headache 

Urinary tract infection 

Rash 

Bullous skin reactions 

Stevens-Johnson syndrome 

Toxic epidermal necrolysis 

Hypertension 

Dysphagia  

Gastric ulcers 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• risedronic acid should not be used in individuals who have a known hypersensitivity or allergy to risedronic acid or any of its components.  

Caution: 

• risedronic acid should not be used in patients with severe hypocalcemia. 
• Patients with a history of gastrointestinal disorders should use with caution.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: C 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

risedronic acid has a high affinity for hydroxyapatite crystals, which are a major component of bone.  

It is incorporated into bone along with it is available for the release during bone resorption. 

Pharmacodynamics 

risedronic acid helps to preserve and increase bone mineral density. This leads to stronger bones and a reduced risk of fractures in individuals with conditions like osteoporosis. 

Pharmacokinetics 

Absorption   

risedronic acid is poorly absorbed from the gastrointestinal tract.  

Distribution 

risedronic acid is distributed to bone tissue.  

Metabolism 

risedronic acid undergoes limited metabolism in the body.  

Elimination and excretion 

risedronic acid is excreted via kidneys.

Adminstartion

Administration 

risedronic acid is administered orally and available in tablet form.

Patient Information Leaflet

Patient information leaflet 

Generic Name: risedronic acid 

Why do we use risedronic acid? 

risedronic acid is used for the treatment and prevention of osteoporosis in postmenopausal women and men who are at an increased risk of fractures. risedronic acid is also used in the treatment of Paget’s disease of bone. Paget’s disease is a chronic disorder in which the normal bone remodelling process is disrupted, leading to the development of abnormal and enlarged bones.