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Brand Name :
Eradacil
Synonyms :
rosoxacin
Class :
Quinolones
Brand Name :
Eradacil
Synonyms :
rosoxacin
Class :
Quinolones
Not determined
Refer to adult dosing
rosoxacin: it may increase the risk of QTc prolongation agents
rosoxacin: it may increase the risk of QTc prolongation agents
rosoxacin: it may increase the risk of QTc prolongation agents
rosoxacin: it may increase the risk of QTc prolongation agents
rosoxacin: it may increase the risk of QTc prolongation agents
when combined with rosoxacin, metabolism of bufylline may be reduced
amoxicillin: it may increase the serum concentration of rosoxacin
ampicillin: it may increase the serum concentration of rosoxacin
anagrelide: it may decrease the metabolism of rosoxacin
antipyrine: it may decrease the metabolism of rosoxacin
antrafenine: it may increase the neuroexcitatory activities of rosoxacin
bendamustine: it may decrease the metabolism of rosoxacin
benorilate: it may increase the neuroexcitatory activities of rosoxacin
Actions and Spectrum
The enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are necessary for bacterial DNA replication, transcription, repair, and recombination are bound by rosoxacin and inhibited by it.
Frequency not defined
Hypersensitivity reactions
Neurological effects
Toxic psychoses or convulsions
Skin reactions
Tendon damage
Nausea
Vomiting
Diarrhea
Abdominal pain
Hepatic effects
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
rosoxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It has actions like nalidixic acid and active against Neisseria gonorrhoeae.
Pharmacodynamics
The antibiotic rosoxacin is a nonfluorinated quinolone. By attaching itself to the enzyme DNA gyrase, it prevents the replication of bacterial DNA, which is how it works.
Pharmacokinetics
Limited information on ADME.
Administration
rosoxacin is available in the form of capsule for oral intake.
Patient information leaflet
Generic Name: rosoxacin
Why do we use rosoxacin?
rosoxacin is used in the treatment of bacterial infection of respiratory and urinary tract.
rosoxacin is used in the treatment of uncomplicated gonorrhoea.
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