Alcohol Consumption Emerges as a Key Risk Factor for Buccal Cancer in India
December 24, 2025
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Brand Name :
Restoril
Synonyms :
temazepam
Class :
Sedative/Hypnotics
Brand Name :
Restoril
Synonyms :
temazepam
Class :
Sedative/Hypnotics
Dosage Forms & Strengths
Capsule
7.5 mg
15 mg
22.5 mg
30 mg
15 - 30
mg
Capsule
Orally
at bedtime
In the case of debilitated patients; 7.5 mg orally before bedtime
7.5
mg
Capsule
Orally
at bedtime
10 - 14
days
may increase the depressant effect of opioid agonists
may increase the depressant effect of opioid agonists
may increase the depressant effect of opioid agonists
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
it increases the effect of CNS depressants
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may increase the serum concentration of each other when it is combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
may enhance the risk of CNS depression when combined
It may enhance sedation when combined with a shepherd's purse
CNS Depressants may enhance the CNS depressant effect of brexanolone
CNS depressants increase the CNS depressing effect of alcohol
may increase the CNS depressant effect
may increase the CNS depressant effect
may have an increased adverse effect when combined with olanzapine.
CNS depressants increase the effect of oxycodone
Action and Spectrum:
Temazepam increase GABA effect that binds with GABA-A receptor site.
CNS depression occurs when membrane permeability of chloride ions increases.
Adverse reaction:
1-10%
Drowsiness
Hangover
Lethargy
Weakness
Euphoria
Vertigo
Dizziness
Confusion
<1%
Amnesia
Blood dyscrasias
Angioedema
Black box warning:
Use of benzodiazepines and opioids together can cause sedation, depression, coma, and death.
Contraindications/caution:
Contraindications:
Cautions:
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: It is present in human breast milk
Pregnancy categories:
Pharmacology: GABA binds to GABA(a) receptors site and opens ion channels for chloride ions in neuron synapses. Local neuron membrane potentials hyperpolarized with chloride ions.
Pharmacodynamics: The modulation induces a sedative state in sleep induction and reduce sleep latency to prolongs sleep duration and enhances quality.
Pharmacokinetic:
Absorption:
It reaches peak plasma time in 2 to 3 hours.
Distribution:
It shows protein bound of 96%.
Metabolism:
The metabolites such as CYP3A4 and glucuronic acid is largely inactive.
Excretion and elimination:
It is excreted through urinary route.
Administration:
It is available in tablet form for oral use.
Patient information leaflet:
Generic Name: temazepam
Why do we use temazepam?
Temazepam is indicated for short-term management of insomnia.
It helps to reduce sleep latency and increases total sleep time of patient.
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