tiaprofenic acid

Action and Spectrum

Actions and Spectrum: 

Actions: 

It is an antipyretic, analgesic, and non-steroidal anti-inflammatory agent, a propionic acid derivative that interferes with the prostaglandin synthetase enzyme responsible for reducing pain and inflammation. The exact mechanism of action needs to be more precise. 

Spectrum: 

The spectrum of tiaprofenic acid, an NSAID, reduces inflammation, pain, and associated symptoms in the treatment of osteoarthritis and Rheumatoid arthritis. 

Drug Interaction

Adverse Reaction

Frequency Defined  

>10% 

Raised BUN (12%) 

Dyspepsia (3-14%)  

1-10% 

Hyperkalemia (2%) 

Edema (1-2%) 

Skin rash (<7%) 

Epistaxis (<1%) 

Depression (<2%) 

Headache (3%) 

Dizziness (2-4%) 

Drowsiness (<3%) 

Xerostomia (<2%) 

Constipation (3%) 

Diarrhea (2-3%) 

Vomiting (1-4%) 

Abdominal pain (2-3%) 

Eipastric pain (3-5%) 

Flatulence (2%) 

Heart burn (3-6%) 

Reduced hematocrit (<3%) 

Reduced hemoglobin (<3%) 

<1% 

Tinnitus 

Urinary Incontinence 

Chest pain 

Oliguria 

Anxiety 

Fatigue 

Raised serum alkaline phosphate 

Raised serum aspartate aminotransferase 

Raised ga,,a-glutamyl transferase 

Asthenia 

Disorientation 

Conjunctivitis 

Insomnia 

Tingling of the fingers 

Polyuria 

Sneezing 

Bruise 

Dyspnea 

Blurred vision 

Eye pruritis 

Leukocytosis 

Eye redness 

Abdominal cramps 

Melena 

Weight gain 

Intermenstrual bleeding 

Anorexia 

Vaginal spotting 

Reduced WBC count  

Frequency Not defined 

Raised Serum creatinine 

Peptic ulcer 

Thrombosis 

Cerebrovascular accident 

Acute MI 

Intestinal obstruction 

Black Box Warning

Black Box Warning: 

There is a severe risk of cardiovascular events, which should be used cautiously in patients with heart disease. It is also used in small doses when any GI adverse event occurs. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Asthma 
• coronary artery bypass graft surgery 
• CHF 
• GI bleeding 
• IBD 
• CBV bleeding 
• Hepatic disease 
• Breastfeeding 
• Urticaria 
• Third trimester pregnancy 
• hyperkalemia 

Cautions 

• HTN 
• Asthma 
• Aseptic meningitis 
• Bariatric surgery 

Pregnancy / Lactation

Pregnancy consideration:  

It crosses the human placenta, which, when used in the third trimester, can lead to miscarriage, which could be due to interference of  cyclooxygenase-2 inhibition with implantation. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

It is an antipyretic, analgesic, and non-steroidal anti-inflammatory agent, a propionic acid derivative that interferes with the prostaglandin synthetase enzyme responsible for reducing pain and inflammation. The exact mechanism of action needs to be more precise. 

Pharmacodynamics: 

It is an antipyretic, analgesic, and non-steroidal anti-inflammatory agent, a propionic acid derivative that interferes with the prostaglandin synthetase enzyme responsible for reducing pain and inflammation. The exact mechanism of action needs to be more precise. The spectrum of tiaprofenic acid, an NSAID, reduces inflammation, pain, and associated symptoms in the treatment of osteoarthritis and Rheumatoid arthritis. 

Pharmacokinetics: 

Absorption 

The drug is absorbed rapidly from the GIT. 

The time to achieve peak effect is 30-90 minutes. 

Distribution 

Protein-bound is 98% 

Metabolism 

The drug is metabolized 10% to inactive metabolites. 

Elimination and Excretion 

The half-life is 2 hours. 

The drug is excreted unchanged about 50% in urine and less than 10% as metabolites. 

Adminstartion

Administration: 

This drug is administered with food orally. In case of a missed dose, the drug should be taken when recognized, but when it is nearer to the next dose, it can be skipped and followed by the next dose. Don’t take two doses at a time. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tiaprofenic acid 

Pronounced: tee-uh-PROF-en-ik AS-id 

Why do we use tiaprofenic acid? 

It is an antipyretic, analgesic, and non-steroidal anti-inflammatory agent, a propionic acid derivative that interferes with the prostaglandin synthetase enzyme responsible for reducing pain and inflammation. The exact mechanism of action needs to be more precise. The spectrum of tiaprofenic acid, an NSAID, reduces inflammation, pain, and associated symptoms in the treatment of osteoarthritis and Rheumatoid arthritis.