Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Aptivus
Synonyms :
tipranavir
Class :
Antiviral agents and Anti-HIV (Protease inhibitor)
Brand Name :
Aptivus
Synonyms :
tipranavir
Class :
Antiviral agents and Anti-HIV (Protease inhibitor)
Dosage Forms & StrengthsÂ
Solution, Oral:Â
100 mg/ml Â
Capsule, Oral:Â
250 mgÂ
500
mg
Capsule
Orally 
twice a day
in combination with ritonavir (200 mg)
Dosage Forms & StrengthsÂ
Solution, Oral:Â
100 mg/ml Â
Capsule, Oral:Â
250 mgÂ
Children >2 years:
14
mg/kg
in combination with 6 mg/kg ritonavir twice a day (NMT 500 mg)
Refer to adult dosingÂ
tipranavir: they may enhance serum concentrations of rifabutin
when both drugs are combined, there may be an increased risk of adverse effects 
may enhance the concentration of serum when combined with salmeterol
may enhance the concentration of serum when combined with ergot derivatives
may enhance the concentration of serum when combined with ergot derivatives
may enhance the concentration of serum when combined with ergot derivatives
may enhance the concentration of serum when combined with ergot derivatives
may enhance the concentration of serum when combined with ergot derivatives
It may enhance when combined with oxycodone by affecting CYP3A4 metabolism
tipranavir: they may enhance the serum concentration of amiodarone
when both drugs are combined, there may be a reduced metabolism of erlotinib  
the effect of tipranavir is increased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
lapatinib increases the effect of tipranavir by altering the intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of tipranavir
tipranavir increases the effect of fedratinib by altering the intestinal/hepatic CYP3A4 enzyme metabolism
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may decrease the level of effectiveness through P-glycoprotein MDR1 efflux transporter
may enhance the serum concentration
may enhance the serum concentration of elbasvir/grazoprevir
may enhance the serum concentration when combined
Tipranavir may enhance the therapeutic concentration of cabozantinib
May decrease the therapeutic effects of cladribine
May enhance the plasma concentration of CYP3A4 substrates
May enhance the plasma concentration of CYP3A4 substrates
May enhance the plasma concentration of CYP3A4 substrates
May enhance the plasma concentration of CYP3A4 substrates
May reduce the therapeutic efficacy of tipranavir
May reduce the therapeutic efficacy of tipranavir
May reduce the plasma concentration of antiretroviral agents
May enhance the therapeutic concentration of tipranavir
Coadministration of tipranavir with warfarin can increase the risk of bleeding or unusual bleeding
may have an increased anticoagulant effect when combined with anticoagulants
may have an increased anticoagulant effect when combined with anticoagulants
may have an increased anticoagulant effect when combined with anticoagulants
may have an increased anticoagulant effect when combined with anticoagulants
may have an increased anticoagulant effect when combined with anticoagulants
it increases the effect of antiplatelet agents
it increases the effect of antiplatelet agents
it increases the effect of antiplatelet agents
it increases the effect of antiplatelet agents
it increases the effect of antiplatelet agents
tipranavir: they may increase the antiplatelet effect of antiplatelet properties
tipranavir: they may increase the antiplatelet effect of antiplatelet properties
tipranavir: they may enhance the serum concentration of glycoprotein IIa Inhibitors
tipranavir: it may enhance the serum concentration of simvastatin
cyclophosphamide effect of action increased by affecting enzyme CYP3A4 metabolism.
has a synergistic effect over brentuximab vedotin by showing altered intestinal/hepatic CYP3A4 enzyme metabolism.
when both drugs are combined, there may be an increased effect of abemaciclib by affecting hepatic or intestinal enzyme cyp3a4 metabolism  
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
may increase the anti-coagulant action of anti-coagulants
It may enhance toxicity when combined with cholic acid by diminishing the elimination
may diminish the serum concentration of each other when combined
metronidazole (Topical): they may increase the adverse effect of tipranavir
tipranavir, when taken with ixazomib, alters the intestinal/hepatic CYP3A4 enzyme metabolism ixaz
Frequency defined:Â Â Â
>10%Â
Skin rashÂ
Vomiting Â
Bronchitis Â
Cough Â
Upper respiratory tract infection Â
Fever Â
1% to 10%:Â
Acute myocardial infectionÂ
Cardiac failure Â
Coronary artery disease Â
Coronary occlusion Â
Endocarditis Â
Hypertension Â
Ischemic heart disease Â
Portal vein thrombosis Â
Septic shockÂ
Unstable angina pectorisÂ
Acne vulgaris Â
Alopecia Â
Folliculitis Â
Nail disease Â
Pruritis Â
Sweat gland diseaseÂ
Lipodystrophy  Â
Frequency not defined:Â
Hepatitis Â
HepatotoxicityÂ
Immune reconstitution syndrome Â
Post-marketing:Â
Stevens-Johnson syndromeÂ
Toxic epidermal necrolysisÂ
Drug rash with eosinophiliaÂ
Â
Pregnancy consideration: Tipranavir may transfer in moderate to high amounts across the human placenta.Â
Lactation: excretion of tipranavir in breast milk is not known. Â
Pregnancy category:Â
Â
Patient information leafletÂ
Generic Name: Tipranavir Â
Pronunciation: tipranavir Â
Why do we use Tipranavir?Â
It is used to treat viral infections such as HIV infection. Â
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