Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Vellergan, Temaril 
Synonyms :
trimeprazine 
Class :
Phenothiazine derivative, antipruritic, Antihistamines 
Brand Name :
Vellergan, Temaril 
Synonyms :
trimeprazine 
Class :
Phenothiazine derivative, antipruritic, Antihistamines 
Dosage forms& StrengthsÂ
Tablet Â
5 mg Â
10 mg Â
10 mg is given orally twice or thrice a day with food
Safety and efficacy were not established Â
Refer to the adult dosing Â
may increase the CNS depressant effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
trimeprazine: they may increase the hypertensive effect of sympathomimetics
trimeprazine: they may increase the hypertensive effect of sympathomimetics
trimeprazine: they may increase the hypertensive effect of sympathomimetics
trimeprazine: they may increase the hypertensive effect of sympathomimetics
trimeprazine: they may increase the hypertensive effect of sympathomimetics
trimeprazine: they may increase the CNS depressant effect of CNS Depressants
trimeprazine: they may increase the CNS depressant effect of CNS Depressants
trimeprazine: they may increase the CNS depressant effect of CNS Depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
promethazine/dextromethorphanÂ
may increase the CNS depressant effect of CNS Depressants
Actions and spectrum:Â
Trimeprazine does not occupy the same receptors as histamine for binding to HA receptors. Therefore, the effect of histamines on these receptors will be less negative and the reduction of the negative symptoms related to the histamine HA-receptor will occur.Â
Adverse reactionsÂ
Dry mouth Â
Upset stomach Â
Headache Â
Abnormal vision Â
Dizziness Â
Skin rash Â
Drowsiness Â
Chest congestion Â
Diarrhea Â
Muscle weakness Â
Difficulty urinating Â
Black box warningÂ
Do not drive vehicles. Sudden deaths may occur in people rarely.Â
Contraindications/CautionÂ
ContraindicationsÂ
HypersensitivityÂ
Acute asthma attacksÂ
Central nervous system depressionÂ
Narrow-angle glaucomaÂ
Prostatic hypertrophyÂ
Stenosing peptic ulcerÂ
Pyloric or duodenal obstructionÂ
CautionsÂ
Respiratory conditionsÂ
Geriatric patientsÂ
Renal impairmentÂ
Hepatic impairmentÂ
PregnancyÂ
LactationÂ
ComorbiditiesÂ
SeizuresÂ
Cardiovascular issuesÂ
Closed- angle glaucomaÂ
Psychiatric conditionsÂ
Pregnancy & breastfeeding:Â
Pregnancy consideration:Â
US FDA pregnancy category: Not assignedÂ
Breastfeeding warnings:Â
Data about the Â
Pregnancy category:Â
Pharmacology:Â
Trimeprazine is a phenozthiazine derivative and an antihistaminic drug. This is also called as Alimemazine.Â
Pharmacodynamics:Â
Trimeprazine is a tricyclic antihistamine is a that is structured similarly to the phenothiazine antipsychotics except it has chain and ring-substitution peculiarities. There is no study for its use as an antipsychotic medication against schizophrenia unlike chlorpromazine or trifluoperazine. However, it is used for drowsiness, antihistaminic effect and prevention of emesis in patients. This drug is known to control the motion sickness and as an antihistamine during the treatment of cough and colds along with other medicines. Also, the tricyclic antihistamines belong to the same structural design as the tricyclic antidepressants, which is exactly that they share the antihistaminergic side effects and the poor tolerability profile.Â
Pharmacokinetics:Â
Absorption: It is well-absorbed after oral administration. The exact mechanism and the rate of absorption may be influenced by factors such as the formulation of the medication and the presence of food in the gastrointestinal tract. Â
Distribution:Â Â
This drug is distributed throughout the body, including central nervous system, due to its lipophilic nature as the drug has the ability to cross the blood-brain barrier.Â
Metabolism:Â Â
It undergoes hepatic metabolism, primarily through the cytochrome P450 enzyme system.Â
Excretion: The drug and its metabolites of are known to be excreted in urine. Â
Administration:Â
The drug must be administered orally with a glass full of water. It is recommended to take it at the same time each day.Â
Patient information leafletÂ
Generic Name: trimeprazineÂ
Why do we use trimeprazine?Â
This is an antihistaminic drug used in the treatment of relieve coughing and itching. It is also indicated in treating some kinds of allergic reactions like urticaria.Â
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