troxerutin

Action and Spectrum

Actions and Spectrum:

Action:

Venotonic Action: troxerutin has venotonic properties, which help improve the tone and elasticity of the veins. It strengthens the vein walls, reducing their tendency to stretch and become less efficient at returning blood to the heart. This action is particularly beneficial in chronic venous insufficiency and varicose veins.

Anti-Inflammatory Action: troxerutin possesses anti-inflammatory properties that can help reduce inflammation in the blood vessel walls. This can be useful in conditions characterized by vascular inflammation, such as phlebitis.

Spectrum:

Chronic Venous Insufficiency: troxerutin is often prescribed for patients with chronic venous insufficiency, where the veins in the legs cannot efficiently return blood to the heart, leading to symptoms like leg swelling, pain, and varicose veins.

Drug Interaction

Adverse Reaction

Frequency not defined

Allergic reaction

Rash

Headache

Indigestion

Gastrointestinal Disorder

Itching

Black Box Warning

Black Box Warning:

None

Contraindication / Caution

Contraindication/Caution:

Hypersensitivity: Individuals who are known to be hypersensitive or allergic to troxerutin or any of its components should avoid its use.

Pregnancy and Breastfeeding: troxerutin’s safety during pregnancy and breastfeeding has not been conclusively established. Pregnant and nursing mothers should seek guidance from their healthcare professional prior to utilizing troxerutin.

Children: troxerutin’s safety and efficacy in children have not been well studied, so it is generally not recommended for pediatric use without consulting a healthcare professional.

Active Bleeding Disorders: troxerutin may have anticoagulant and antiplatelet effects. Individuals with active bleeding disorders, such as hemophilia or peptic ulcers, should avoid troxerutin as it might increase the risk of bleeding.

Anticoagulant Medications: troxerutin should not be taken concurrently with anticoagulant medications like warfarin, heparin, or antiplatelet drugs like aspirin, as it may increase the risk of bleeding. If someone is on such medications, they should consult their healthcare provider before using troxerutin.

Pregnancy / Lactation

Pregnancy warnings:   

Pregnancy category: N/A

Lactation: Excreted into human milk is unknown

Pregnancy Categories:

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

troxerutin has potential pharmacological effects primarily related to its action on blood vessels and inflammation

Pharmacodynamics:

Vasoprotective Effect: troxerutin strengthens and stabilizes blood vessel walls, particularly the capillaries. It does this by reducing the permeability and fragility of blood vessels. This property makes it useful in the management of various vascular disorders.

Anti-Inflammatory Activity: troxerutin has demonstrated its anti-inflammatory properties through its ability to suppress the release of pro-inflammatory cytokines and diminish the migration of inflammatory cells to areas of injury or inflammation.

Pharmacokinetics:

Absorption

troxerutin is absorbed through the intestinal mucosa and enters the bloodstream.

Various factors, such as food intake and the presence of other substances, may influence the absorption of troxerutin.

Distribution

troxerutin is distributed throughout the body via the bloodstream. It has been reported to have a high affinity for blood vessel walls, which is one of the reasons for its use in treating vascular conditions.

Metabolism

troxerutin undergoes metabolism in the liver and possibly other tissues. The specific metabolic pathways and metabolites of troxerutin may vary, but it is generally subjected to phase II metabolism, which involves conjugation reactions.

Excretion and Elimination

After metabolism, the metabolites of troxerutin are excreted from the body.

The primary route of excretion is through the urine and, to a lesser extent, through feces.

The elimination half-life of troxerutin may vary depending on individual factors and dosage forms but generally ranges from a few hours to several hours.

Adminstartion

Administration: 

troxerutin is available in various forms, such as capsules, tablets, creams, and gels. If using troxerutin in cream or gel form for skin conditions like varicose veins or hemorrhoids, apply a thin coating and gently massage it into the affected region.

Patient Information Leaflet

Patient information leaflet

Generic Name: troxerutin

Why do we use troxerutin?

Chronic Venous Insufficiency: It is commonly used to manage chronic venous insufficiency, a condition characterized by poor blood flow, often resulting in leg swelling, pain, and varicose veins.

Capillary Fragility: Due to its ability to strengthen blood vessel walls, troxerutin may be recommended for conditions involving capillary fragility, such as easy bruising.

Edema: It may be used to reduce edema (fluid retention) associated with various conditions.

Antioxidant Support: Some individuals use troxerutin as a dietary supplement to support overall health and as an antioxidant.