Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Trintellix
Synonyms :
vortioxetine
Class :
Antidepressant and selective serotonin 5-HT3 receptor antagonists
Brand Name :
Trintellix
Synonyms :
vortioxetine
Class :
Antidepressant and selective serotonin 5-HT3 receptor antagonists
Dosage Forms & Strengths
Tablet, Oral:
5 mg
10 mg
20 mg
10
mg/day
Tablet
Oral
initially, increase/decrease the dose based on patient tolerance
Dosage Forms & Strengths
Tablet, Oral:
5 mg
10 mg
20 mg
5
mg/day
Tablet
Oral
initially, increase up to 10 mg/day if tolerated
may have an increased antiplatelet effect when combined with NSAIDs
may have an increased antiplatelet effect when combined with NSAIDs
may have an increased antiplatelet effect when combined with NSAIDs
may have an increased antiplatelet effect when combined with NSAIDs
may have an increased antiplatelet effect when combined with NSAIDs
acetaminophen/doxylamine/dextromethorphanÂ
may increase the serotonergic effect when combined
CYP3A strong enhancers of the small intestine may reduce the bioavailability of vortioxetine
may increase the serotonergic effect of tricyclic antidepressants
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the anticoagulant effect of Vitamin K antagonists
may enhance the hypoglycemic effect of agents with blood glucose lowering effects
may enhance the hypoglycemic effect of agents with blood glucose lowering effects
may enhance the hypoglycemic effect of agents with blood glucose lowering effects
may enhance the hypoglycemic effect of agents with blood glucose lowering effects
may enhance the hypoglycemic effect of agents with blood glucose lowering effects
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
It may enhance the risk of bleeding by affecting coagulation when combined with omega-3 carboxylic acids
selective serotonin reuptake inhibitors: they may increase the hypoglycemic effect of blood viscosity reducing agents
selective serotonin reuptake inhibitors: they may increase the hypoglycemic effect of blood viscosity reducing agents
vortioxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
vortioxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
vortioxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
vortioxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
vortioxetine: they may enhance the serum concentration of CYP2D6 Inhibitors
mycophenolic acid may decrease the excretion rate of vortioxetine, potentially resulting in higher serum levels
vortioxetine may lower the excretion rate of n-acetyl tyrosine, potentially resulting in elevated serum levels
vortioxetine may lower the excretion rate of sulbactam, potentially resulting in a higher serum level
the effect of vortioxetine is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
it may increase the effect of other selective serotonin reuptake inhibitors
may enhance the risk or severity of hypertension when combined
may increase the serum concentrations of CYP2D6 inhibitors
may increase the antiplatelet effect of nonsteroidal anti-inflammatory agents
may increase the serotonergic effect of Serotonin 5-HT1D Receptor Agonists
the risk of hypertension may be increased
Frequency defined:
>10%
Mania
Hypomania
Angle-closure glaucoma
Seizures
Fractures
Hyponatremia
1% to 10%
Dizziness
Nausea
Diarrhea
Vomiting
Flatulence
Dry mouth
Abnormal dreams
Pruritis
<1%:
Neuroleptic malignant syndrome
Serotonin syndrome
Haemorrhage
Suicidal ideation
Pregnancy consideration: Not safe, risk of pulmonary hypertension in an infant. It Falls under category Z.
Lactation: vortioxetine can be excreted in breast milk. Not recommended during lactation.
Â
Pregnancy category:
Patient information leaflet
Generic Name: Vortioxetine
Pronounced: vortioxetine
Why do we use vortioxetine?
Vortioxetine is used for the treatment of major depressive disorder.
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