Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
Zurzuvae
Synonyms :
zuranolone
Class :
GABA Receptor Positive Modulators, Antidepressants
Brand Name :
Zurzuvae
Synonyms :
zuranolone
Class :
GABA Receptor Positive Modulators, Antidepressants
Dosage Forms & Strengths
capsule
20mg
25mg
30mg
50
mg
Capsule
orally
once daily in the evening
14
days
In case CNS depressant effects are observed during the 14-day treatment period, consider reducing the dose to 40 mg
Zurzuvae can be used as a standalone treatment for PPD or as an adjunct to oral antidepressant therapy
Note:
It is important to note that using Zurzuvae beyond the 14-day treatment course in a single treatment regimen has not been established
Safety and efficacy not established
Refer adult dosing
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
may enhance the metabolism when combined with tricyclic antidepressants
amitriptylinoxide(Phase 4 Clinical Trials)Â
may increase the pharmacodynamic effect of each other when combined
may enhance the risk of CNS depression when combined with each other
may enhance the risk of CNS depression when combined with each other
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
could increase the vasopressor action
may have an increased therapeutic effect when combined with alpha1-agonists
may affecting the metabolism and increase the side effects when combined with kratom
may enhance the QTc-prolonging effect of each other when combined
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
It may enhance the risk of adverse effects when combined with Interleukins
may have an increased serotonergic effect when combined with tricyclic antidepressants
may have an increased serotonergic effect when combined with tricyclic antidepressants
may have an increased serotonergic effect when combined with tricyclic antidepressants
may have an increased serotonergic effect when combined with tricyclic antidepressants
may have an increased serotonergic effect when combined with tricyclic antidepressants
the serum concentration of zuranolone may be reduced when combined with asunaprevir
the risk of CNS depression may be increased
the risk of CNS depression may be increased
the risk of CNS depression may be increased
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
may have an increased serotonergic effect when combined with serotonin/norepinephrine reuptake inhibitors
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the effect of CNS depressants
it increases the toxicity of muscle relaxants
it increases the toxicity of muscle relaxants
it increases the toxicity of muscle relaxants
Actions and Spectrum:Â
zuranolone works by controlling the brain’s GABA receptors’ level of activity. An inhibitory neurotransmitter, GABA helps control neuronal activity and contributes to relaxation and anxiety reduction.
zuranolone amplifies the effects of GABA by attaching to a specific location on GABA receptors, which results in greater inhibition of neuronal activity. Research and development on zuranolone are primarily focused on its potential as a therapy for many mood and anxiety disorders.
Frequency not defined
Dizziness
Tiredness
Common cold
Urinary tract infection
Diarrhea
Sleepiness or drowsiness
Black Box Warning:
It may lead to a decrease in awareness and alertness. This can result in impaired abilities to drive safely.
Contraindication:
None
Caution:
Zurzuvae can cause CNS depressant effects, leading to symptoms like sleepiness and confusion. If patients experience such effects, healthcare providers should consider adjusting the dosage or discontinuing the medication.
Patients taking Zurzuvae should be closely monitored for changes in their mental health, particularly regarding suicidal thoughts and behaviors. If a patient’s postpartum depression worsens or they develop emergent suicidal thoughts and behaviors, it is crucial to reassess the treatment plan, which might include discontinuing Zurzuvae.
Zurzuvae may present a risk of harm to the developing fetus if taken during pregnancy. Pregnant women should be informed about the potential risks to the baby exposed to Zurzuvae in the womb. Women capable of becoming pregnant should be advised about the potential risk to a fetus and the importance of using effective contraception during Zurzuvae treatment and for one week after the final dose.
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknown
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology: Â
zuranolone interacts with GABA receptors in the brain as part of its pharmacology. An essential part of controlling neuronal activity is the inhibitory neurotransmitter GABA. zuranolone functions as a positive allosteric modulator by interacting with GABA receptor binding sites. This indicates that it boosts the inhibitory activity of GABA and strengthens its effect on neuronal signaling.
Pharmacodynamics:Â
zuranolone raises the inhibitory tone in the brain by amplifying the effects of GABA. This improves GABAergic neurotransmission, which is essential for controlling neuronal activity and preserving the proper ratio of excitement to inhibition in the central nervous system.
Pharmacokinetics:
Absorption Â
The process by which a medicine enters the bloodstream from its place of administration is referred to as absorption. Drugs that are taken orally, like zuranolone, would be absorbed by the digestive system. Its absorption may be impacted by elements like solubility, stability, and the presence of food or other medications.
Distribution Â
After a medicine enters the bloodstream, it moves through the body through a process called distribution. Molecular size, lipophilicity, protein binding, and tissue permeability are a few examples of variables that might affect how extensively and uniformly a medicine is delivered to various organs and tissues.
MetabolismÂ
The main place where drugs are broken down by enzymes to make them more soluble in water for excretion is the liver. The specific enzymes and metabolic pathways involved in the metabolism of zuranolone would need to be identified using the information currently available.
Elimination and Excretion Â
Elimination is the process of getting rid of drugs and their metabolites from the body. Most medications are mostly eliminated through the kidneys, where they are expelled in urine.
Administration: Â
Oral Administration:
To enhance absorption, this medication should be taken with food that contains fat (e.g., 400 to 1,000 cal, fat 25-50%).
Patient information leafletÂ
Generic Name: zuranolone
Why do we use zuranolone?Â
Zurzuvae (zuranolone) capsules are specifically designed to treat postpartum depression (PPD). This rapid-acting medication is taken once daily for 14 days. Unlike current treatment options that may take weeks or months to show improvements in depression symptoms, Zurzuvae works quickly to alleviate PPD symptoms.
Zurzuvae is the first oral medication to receive FDA approval for the treatment of postpartum depression. During its development stages, it was known by the names SAGE-217 and BIIB125 before being marketed under the brand name Zurzuvae. This medication represents a significant advancement in the treatment of postpartum depression, providing a potentially faster and more effective option for women experiencing this condition.
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