Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Lotronex
Synonyms :
alosetron
Class :
IBS Agents; Selective 5-HT3 Receptor Antagonists
Brand Name :
Lotronex
Synonyms :
alosetron
Class :
IBS Agents; Selective 5-HT3 Receptor Antagonists
Dosage forms & Strengths:Â
TabletÂ
0.5 mgÂ
1 mgÂ
Irritable Bowel Syndrome (IBS)Â
0.5 mg orally every 12 hours for 4 weeks
Not recommended for pediatricsÂ
alosetron: it may increase the risk of CNS depression
alosetron: it may increase the risk of CNS depression
alosetron: it may increase the risk of CNS depression
CYP1A2 Inhibitors may increase the serum concentration of Alosetron
ciprofloxacin inhaled (Pending FDA approval)Â
may enhance the serum concentration of CYP1A2 Inhibitors
may enhance the serum concentration of CYP1A2 Inhibitors
may have an increased effect of CNS depression when combined with Alosetron
may increase the risk of CNS depression when combined
they increase the concentration of alosetron in the serum
they increase the concentration of alosetron in the serum
they increase the concentration of alosetron in the serum
they increase the concentration of alosetron in the serum
they increase the concentration of alosetron in the serum
it decreases the metabolism of alosetron
alosetron increases the effect of constipation of eluxadoline
ciprofloxacin will increase the level or effect of alosetron by affecting hepatic enzyme cyp1a2 metabolism. Avoid or use alternate drug. Alosetron is associated with potentially severe and life-threatening, dose-related gastrointestinal adverse effects, concomitant use with cyp450 1a2 inhibitors should avoid.
alosetron increases the effect of serotonergic agents
it increases the concentration of alosetron in the serum
it increases the concentration of alosetron in the serum
it increases the concentration of alosetron in the serum
it increases the concentration of alosetron in the serum
it increases the concentration of alosetron in the serum
Strong inhibitors of CYP3A4 have the potential to increase the serum concentration of alosetron
Strong inhibitors of CYP3A4 have the potential to increase the serum concentration of alosetron
The potential for enhanced CNS depression exists when halazepam is utilized concurrently with alosetron
ximelagatran (investigational)Â
The combination of alosetron may lead to a reduced metabolism of ximelagatran
Combining alosetron with pranlukast may cause a reduction in the alosetron’s metabolism
The potential for increased CNS depression risk or seriousness occurs when alosetron is used together with pinazepam
It may diminish the metabolism when combined with nilvadipine
The potential for CNS depression may enhanced when alosetron is used together with fencamfamin
Combining tegafur with alosetron can reduce tegafur’s metabolism
When alosetron is used together with medazepam, the risk or seriousness of CNS depression is enhanced
alosetron may intensify paraldehyde's CNS depressant effects
When alosetron is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
when alosetron is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When domeperidone and alosetron is used together, this leads to reduction in the domeperidone’s metabolism
When alosetron is used together with fluconazole, this leads to reduction in the alosetron metabolism
When chlordiazepoxide is used together with alosetron, this leads to enhanced risk or seriousness of CNS depression
When alosetron is used together with somatotropin, this leads to a rise in alosetron metabolism
When alosetron is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with alosetron, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with alostetron, this leads to enhanced risk or seriousness of CNS depression
When alosetron is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When isoflurane is used together with alosetron, this leads to enhanced risk or seriousness of CNS depression
When hexafluronium is used together with alosetron, this leads to enhanced risk or seriousness of CNS depression
alosetron: it may increase the risk or severity of CNS depression
alosetron: it may increase the risk or severity of CNS depression
alosetron: it may increase the risk or severity of CNS depression
alosetron: it may increase the risk or severity of CNS depression
alosetron: it may increase the risk or severity of CNS depression
it decreases the concentration of alosetron in the serum
may enhance the serum concentration of CYP3A4 inhibitors
the rate of metabolism of alosetron may be reduced
the rate of metabolism of alosetron may be reduced
the risk of CNS depression may be increased
the risk of CNS depression may be increased
>10%:Â
1-10%:Â
Abdominal pain Â
Nausea Â
Headache Â
GI discomfort and pain Â
Fatigue Â
Gastroenteritis Â
Flatulence Â
Regurgitation and refluxÂ
Abdominal distension Â
Hemorrhoids Â
Urinary tract infection Â
Muscle spasm Â
Cough Â
Nasopharyngitis Â
<1%:Â
AnxietyÂ
Ischemic colitisÂ
ColitisÂ
Bone painÂ
CholecystitisÂ
DiverticulitisÂ
GI spasmsÂ
GI impactionÂ
GI ulcerationÂ
Alosetron is contraindicated in patients hypersensitive to the formulation’s active ingredient and other excipients.Â
Pregnancy consideration:Â Â
Insufficient data is available regarding usage during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of the drug in breast milk.Â
Monitoring the breastfed infant is important if lactation is done during drug therapy. The infant may get blood in stools or constipation.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: alosteronÂ
Pronounced: a-los-ter-onÂ
Why do we use alosteron?Â
Alosteron belongs to the category of IBS agents. It treats irritable bowel syndrome. Â
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