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Brand Name :
Trasylol
Synonyms :
aprotinin
Class :
Proteinase inhibitor/Antifibrinolytics/Hemostatics
Brand Name :
Trasylol
Synonyms :
aprotinin
Class :
Proteinase inhibitor/Antifibrinolytics/Hemostatics
Dosage Forms & Strengths
Injectable solution
10000 kallikrein inhibitor units/ml
Coronary Artery Stent Thrombosis, Prevention
10,000 KIU test dose ten minutes prior to the procedure.
The loading dose consists of 1,000,000–2,000,000 KIU administered slowly by IV infusion or over a 20–30-minute period following the induction of anesthesia and 250,000–500,000 KIU/hour administered continuously until the procedure is completed
To the heart-lung machine's pump prime, an extra dose of 1,000,000–2,000,000 KIU is added. Maximum: 7 million KIU
Maximum flow: 5–10 mL/min
Data not available
Refer to adult dosing
there may be an increased risk of renal impairment
neomycin/polymyxin B/bacitracin topical
there may be an increased risk of renal impairment
there may be an increased risk of renal impairment
there may be an increased risk of renal impairment
there may be an increased risk of renal impairment
there may be inhibition of the activity of thrombolytic agents in a dose-dependent manner
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
may decrease the antihypertensive effect when combined with angiotensin-converting enzyme inhibitors
menadione could potentially enhance the thrombogenic effects of aprotinin
aprotinin might enhance levobetaxolol’s bradycardic effects
aprotinin: they may increase the CNS depressant effect of CNS Depressants
aprotinin: they may increase the CNS depressant effect of CNS Depressants
aprotinin: they may increase the CNS depressant effect of CNS Depressants
aprotinin: they may increase the CNS depressant effect of CNS Depressants
aprotinin: they may increase the CNS depressant effect of CNS Depressants
when both drugs are combined, there may be a decrease in the therapeutic effect
When aprotinin is used together in combination with profenamine, this leads to reduction in therapeutic effectiveness of profenamine
Actions and spectrum:
Aprotinin inhibits proteolytic enzymes like kallikrein, plasmin, trypsin, and chymotrypsin. And it suppresses the activation of coagulation during the contact phase which begins the coagulation process and stimulates fibrinolysis.
Frequency not defined
Myocardial ischemia
Pericardial efflusion
Acute renal failure
Thrombosis
Oliguria
Arterial thrombosis
Coronary occlusion
Necrosis of renal tubules
Hypotension
Fatal: anaphylactic reactions
Black Box Warning
High risk of deaths
Contraindication/Caution:
Hypersensitivity
Pregnancy consideration:
USFDA pregnancy category: B
Lactation:
Data about the excretion of aprotinin into human milk is not known
Pregnancy category:
Pharmacology:
Aprotinin is a hemostatic agent
Pharmacodynamics:
Pharmacokinetics:
Absorption
It is rapidly absorbed.
Distribution
Peak plasma time is 150 mins.
Metabolism
The metabolism occurs in kidney to amino acids or smaller peptides due to lysosomal activity.
Elimination and excretion
It is eliminated through urine with half-life 5 hrs.
Administration:
Aprotinin is given as IV infusion with a test dose administered before the first dose.
Patient information leaflet
Generic Name: aprotinin
Why do we use aprotinin?
Aprotinin is a proteinase inhibitor which is used as an alternative therapy in coronary bypass grafts to prevent the blood loss.
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