Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Lioresal, Ozobax, Fleqsuvy, Lioresal, Lyvispah
Synonyms :
baclofen
Class :
Skeletal Muscle Relaxants
Brand Name :
Lioresal, Ozobax, Fleqsuvy, Lioresal, Lyvispah
Synonyms :
baclofen
Class :
Skeletal Muscle Relaxants
Dosage forms & Strengths:
Adult:
Tablet
5 mg
10 mg
20 mg
Oral solution (Ozobax)
5 mg/ml
Oral suspension (Fleqsuvy)
25 mg/5 ml
Oral granules
5mg/packet (Lyvispah)
10mg/packet (Lyvispah)
20mg/packet (Lyvispah)
Intrathecal solution
500mcg/mL (generic, Gablofen, Lioresal)
1000mcg/mL (generic, Gablofen Lioresal)
2000mcg/mL (generic, Gablofen, Lioresal)
Dosage forms & Strengths:
Tablet
5 mg
10 mg
20 mg
Oral solution (Ozobax)
5 mg/ml
Oral suspension (Fleqsuvy)
25 mg/5 ml
Oral granules
5mg/packet (Lyvispah)
10mg/packet (Lyvispah)
20mg/packet (Lyvispah)
Intrathecal solution
500mcg/mL (generic, Gablofen, Lioresal)
1000mcg/mL (generic, Gablofen Lioresal)
2000mcg/mL (generic, Gablofen, Lioresal)
Refer to the adult dosing
may have an increased risk of rhabdomyolysis & myoglobinuria when combined with baclofen
the excretion rate of amikacin may be decreased by oxybenzone, leading to increased serum levels of amikacin
It may enhance sedation when combined with tramadol
It may enhance the toxicity when combined with mipomersen
it may diminish the excretion rate when combined with corifollitropin alfa resulting in an enhanced serum level
baclofen has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
baclofen leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of baclofen which leads to increased level of serum
baclofen leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
baclofen leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
baclofen leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
baclofen leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
the excretion rate of gadopentetic acid may be decreased by baclofen, leading to a higher serum level
baclofen leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
baclofen: it may decrease the excretion rate of iothalamic acid
baclofen: it may increase the risk or severity of CNS depression
baclofen: it may increase the risk or severity of CNS depression
baclofen: it may increase the risk or severity of CNS depression
baclofen: it may increase the risk or severity of CNS depression
baclofen: it may increase the risk or severity of CNS depression
the central nervous system depressant (cns depressant) activities of ramosetron may be increased by baclofen
baclofen: it may increase the risk of CNS depression
baclofen: it may increase the risk of CNS depression
baclofen: it may increase the risk of CNS depression
balclofen: it may increase the risk of gastrointestinal bleeding with risedronic acid
baclofen: it may decrease the excretion rate of metheglobinemia associated agents
baclofen: it may decrease the excretion rate of metheglobinemia associated agents
baclofen: it may decrease the excretion rate of metheglobinemia associated agents
baclofen: it may decrease the excretion rate of metheglobinemia associated agents
baclofen: it may decrease the excretion rate of metheglobinemia associated agents
baclofen may decrease the excretion rate of almasilate, leading to higher serum levels
diphenoxylate, when used with baclofen, increases sedation
nabilone and baclofen, when used simultaneously, both increase the sedation
sedative effects can be increased when baclofen is administered with papaverine
the excretory rate of baclofen may be reduced, leading to high serum levels of baclofen when combined with bumadizone
the rate of excretion of aurothioglucose may be reduced with baclofen
the rate of excretion of inositol may be reduced
the therapeutic effect of gallamine triethiodide may be increased
the rate of excretion of topiroxostat may be reduced
remacemide may enhance the central nervous system depressant (CNS depressant) activities of baclofen
the CNS depressant activity of articaine may be increased
the risk of CNS depressant activity of meptazinol may be increased
an increase in CNS depressant activity of alverine may be increased
the rate of excretion of phosphoric acid may be decreased
the CNS depression activity of zotepine may be enhanced with baclofen
baclofen might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
it increases the toxicity of muscle relaxants
Actions and Spectrum:
baclofen is a muscle relaxant and antispastic medication. It works by blocking nerve impulses that cause muscle contractions and spasms. baclofen acts on the GABAB receptors in the central nervous system and reduces the excitability of the muscles.
The spectrum of baclofen’s action includes:
>10%:
Dizziness (5-15%)
Drowsiness (10-63%)
Nausea (4-12%)
Weakness (5-15%)
Confusion (1-11%)
Somnolence (5.7-20.9%)
Hypotonia (2.4-34.7%)
1-10%:
Hypotension (0-9%)
Headache (4-8%)
Insomnia (2-7%)
Constipation (2-6%)
Urinary frequency (2-6%)
Fatigue (2-4%)
<1%:
Diplopia (0.4-0.9%)
Anorexia (0.4-0.9%)
Dysautonomia (0.2-0.9%)
Fever (0.2-0.7%)
Anxiety (0.2-0.9%)
Hypertension (0.2-0.6%)
Hallucinations (0.3-0.5%)
Urinary frequency (0.6-0.9%)
Frequency not defined:
Dyspnea
Dry mouth
Enuresis
Rash
Pruritis
Edema
Tremor
Chest pain
Epileptic seizure
Black Box Warning:
Abrupt discontinuation of baclofen can lead to severe and potentially life-threatening withdrawal symptoms. These symptoms include high fever, altered mental status, muscle rigidity, and in severe cases, rhabdomyolysis, multiple organ system failure, and death.
Contraindication/Caution:
Contraindications:
Caution:
Pregnancy consideration:
No adequate data is available regarding the usage of the drug during pregnancy.
Breastfeeding warnings:
The drug is excreted in breast milk. Consider the developmental changes and the health benefits for both mother and the infant.
Pregnancy category:
Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
baclofen works by blocking nerve impulses that cause muscle contractions and spasms. Baclofen acts on the GABAB receptors in the central nervous system and reduces the excitability of the muscles.
Pharmacodynamics:
baclofen acts on the GABAB receptors in the central nervous system and reduces the excitability of the muscles. This results in the relaxation of muscle tone and reduced muscle spasms and stiffness.
Pharmacokinetics:
Administration:
Take baclofen orally with or without food.
Store the tablets at room temperature.
Patient information leaflet
Generic Name: baclofen
Pronounced: bak-lo-fen
Why do we use baclofen?
baclofen is used to treat spasticity, muscle stiffness, and muscle spasms associated with various medical conditions.
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