Performance Comparison of Microfluidic and Immunomagnetic Platforms for Pancreatic CTC Enrichment
November 15, 2025
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Brand Name :
BuSpar, LinBuspirone, Buspirex, Bustab
Synonyms :
buspirone
Class :
Anti-anxiety Agents; Anxiolytics, Nonbenzodiazepines
Brand Name :
BuSpar, LinBuspirone, Buspirex, Bustab
Synonyms :
buspirone
Class :
Anti-anxiety Agents; Anxiolytics, Nonbenzodiazepines
Dosage forms & Strengths:
Adult:
Tablet
5 mg
7.5mg
10mg
15mg
30mg
Dosage forms & Strengths:
Tablet
5 mg
7.5mg
10mg
15mg
30mg
Refer to the adult dosing
may enhance the serum concentration of CYP3A4 inhibitors
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
it increases the concentration of CYP3A4 substrates in the serum
buspirone increases the serotonergic effect of MAO inhibitors
buspirone increases the serotonergic effect of MAO inhibitors
buspirone increases the serotonergic effect of MAO inhibitors
buspirone increases the serotonergic effect of MAO inhibitors
buspirone increases the serotonergic effect of MAO inhibitors
It may enhance the effect when combined with lonafarnib by affecting CYP3A4 metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of buspirone
May have an increased serotonergic effect when combined with Serotonergic Agents
It may enhance the effect when combined with grapefruit by CYP3A4 metabolism
it may diminish the excretion rate when combined with permethrin, resulting in an enhanced serum level
It may enhance the effect when combined with miconazole vaginal by affecting CYP3A4 metabolism
may enhance the concentration of serum when combined with buspirone
The potential for increased CNS depression risk or seriousness occurs when buspirone is used together with pinazepam
When buspirone is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
buspirone has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When captodiame is used together with buspirone, There is a risk or seriousness of CNS depression is enhanced
When buspirone is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when buspirone is used together with fencamfamin
Combining tegafur with buspirone can reduce tegafur’s metabolism
When buspirone is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When domeperidone and buspirone is used together, this leads to reduction in the domeperidone’s metabolism
buspirone: they may enhance the serum concentration of CYP3A Inhibitors
buspirone: they may enhance the serum concentration of CYP3A Inhibitors
When buspirone is used together with fluconazole, this leads to reduction in the buspirone metabolism
When chlordiazepoxide is used together with buspirone, this leads to enhanced risk or seriousness of CNS depression
When encainide is used together with buspirone, this leads to a reduction in the encainide’s metabolism
When emylcamate is used together with buspirone, this leads to enhanced risk or seriousness of CNS depression
When buspirone is used together with etizolam, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with buspirone, this leads to enhanced risk or seriousness of CNS depression
buspirone leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefpirome leads to a reduction in the rate of excretion of buspirone which leads to increased level of serum
buspirone leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
buspirone leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
buspirone leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
buspirone leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
the metabolism of buspirone may undergo a reduction when combined with cholecalciferol
buspirone may decrease the excretion rate of almasilate, leading to higher serum levels
When buspirone is used together with diazoxide, this leads to reduction in diazoxide’s antihypertensive effects
the effect of buspirone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
fedratinib increases the effect of buspirone by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
may increase the risk or severity of hypertension when combined
an increase in severity of hypertension may be seen when buspirone is administered with kebuzone
an increase in risk of hypertension can be seen when buspirone is taken with mufebutazone
the risk of hypertension may be increased
buspirone might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
CYP3A4 inducers increase the concentration of buspirone in the serum
CYP3A4 inducers increase the concentration of buspirone in the serum
CYP3A4 inducers increase the concentration of buspirone in the serum
CYP3A4 inducers increase the concentration of buspirone in the serum
CYP3A4 inducers increase the concentration of buspirone in the serum
Actions and Spectrum:
buspirone works by increasing neurotransmitters such as dopamine and norepinephrine levels in the brain. This help alleviates anxiety symptoms.
>10%:
Dizziness (12%)
1-10%:
Blurred vision (2%)
Confusion (2%)
Headache (6%)
Nervousness (5%)
Diarrhea (2%)
Numbness (2%)
Drowsiness (10%)
Nausea (8%)
Paresthesia (1%)
Rash (1%)
Excitement (2%)
Insomnia (2%)
Myalgia (1%)
Tremor (1%)
Sore throat (1%)
Nonspecific chest pain (1%)
Weakness (2%)
Nasal congestion (1%)
Dream disturbances (1%)
Tinnitus (1%)
<1%:
Akathisia
Anorexia
Heart failure
Suicidal ideation
Alopecia
Edema
Visual disturbances
Photophobia
Visual disturbances
Photophobia
Rectal bleeding
Dystonia
Contraindication/Caution:
buspirone should not be taken by individuals hypersensitive to the drug or its ingredients.
Individuals with a history of liver or kidney disease should take the drug cautiously.
buspirone may cause drowsiness or dizziness, so caution should be exercised when operating heavy machinery or driving a vehicle.
Pregnancy consideration:
Category B
Breastfeeding warnings:
The drug is not recommended during breastfeeding.
Pregnancy category:
Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
buspirone is a medication in the class of drugs known as anxiolytics or anti-anxiety medications. It works by increasing dopamine and norepinephrine in the brain which can help to alleviate anxiety symptoms.
Pharmacodynamics:
The pharmacodynamics of buspirone involve its interactions with specific neurotransmitter systems in the brain. buspirone is believed to act as a partial agonist at serotonin (5-HT1A) receptors and as an antagonist at dopamine (D2) receptors.
buspirone increases serotonin activity in the brain by acting as a partial agonist at 5-HT1A receptors. buspirone decreases dopamine activity in the brain by acting as an antagonist at dopamine D2 receptors. Dopamine is a neurotransmitter that regulates mood, motivation, and reward.
Pharmacokinetics:
Absorption:
The bioavailability is 4%
The onset of action is from 2-4 weeks
Peak serum is achieved in 40-90 min
Peak plasma concentration is achieved in 1-6 ng/ml
Distribution:
The value of bound protein is 86%
The volume of distribution is 5.3 L/kg
Metabolism:
The metabolites of buspirone are 1-pyrimidinylpiperazine (1-PP)
Elimination:
The half-life is achieved in 2-3 hours
The drug is excreted 29-63% in urine and 18-38% in feces.
The rate of total body clearance is 28/ml/min/kg
Administration:
buspirone is usually taken orally, in the form of a tablet, two or three times a day with or without food. The recommended starting dose is typically 5 mg two or three times a day, and the dose may be increased by 5 mg every two to three days until a therapeutic dose is reached. The maximum recommended daily dose is 60 mg. buspirone can cause withdrawal symptoms if it is stopped suddenly, so it should be tapered off gradually under a doctor’s supervision.
Patient information leaflet
Generic Name: buspirone
Pronounced: byoo-SPYE-rone
Why do we use buspirone?
buspirone is used as an anxiolytic medication. It treats anxiety disorders such as generalized anxiety disorder (GAD).
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