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Brand Name :
Zefazone
Synonyms :
cefmetazole, Cefmetazolo, Cefmetazolum
Class :
Beta Lactam, Second generation cephalosporins, Cephamycins
Brand Name :
Zefazone
Synonyms :
cefmetazole, Cefmetazolo, Cefmetazolum
Class :
Beta Lactam, Second generation cephalosporins, Cephamycins
Dosage Forms & StrengthsÂ
Parenteral (IM/IV)Â
1 gÂ
2 gÂ
1 g/50 mLÂ
2 g/50 mLÂ
Parenteral administration of 0.5-1 g twice a day via IV or slow IV injection over 3-5minutes
For serious infection dose is 3-4 g 3 times daily is recommended treatment of infection
IV infusion dose can be given over 10-60 minutes daily
Parenteral administration of 0.5-1 g twice a day via IV or slow IV injection over 3-5minutes. For severe infection, a dose of 3-4 g 3 times daily is recommended treatment of infection. IV infusion dose can be given over 10-60 minutes daily.
Dose Adjustments
Renal Dose Adjustments
A dose of 1 -2 g IV administration is necessary for every 48 hours if CrCl is below 10 mL/min, for every 24 hours if CrCl is between 10 and 29 mL/min, for every 16 hours if CrCl is between 30 and 49 mL/min and for every 12 hours if CrCl is between 50 and 90 mL/min respectively.
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosingÂ
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion leading to a higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may increase the anticoagulant effect of vitamin K antagonists
may increase the anticoagulant effect of vitamin K antagonists
may increase the anticoagulant effect of vitamin K antagonists
may increase the anticoagulant effect of vitamin K antagonists
may increase the anticoagulant effect of vitamin K antagonists
they increase the effect of nephrotoxicity of aminoglycosides
neomycin/polymyxin B/bacitracin topical
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
they increase the effect of nephrotoxicity of aminoglycosides
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
cefmetazole has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When cefmetazole is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
excretion rate of abacavir, which leads to high-level serum concentration, is reduced when interacting with cefmetazole
efficacy of abciximab is altered with cefmetazole
high nephrotoxic reactions occur when cefmetazole interacts with aceclofenac
bleeding will increase when cefmetazole is combined with acenocoumarol
high nephrotoxic reactions occur when cefmetazole interacts with acetylsalicylic acid
When cefmenoxime is used together with cefmetazole, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmetazole is used together with proglumetacin, this leads to enhanced risk or seriousness of nephrotoxicity
When cefmetazole is used together with benoxaprofen, this leads to enhanced risk or seriousness of nephrotoxicity
cefmetazole leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefmetazole leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
cefmetazole leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefmetazole leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefmetazole is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
may diminish the rate of excretion which results in higher serum level
cefmetazole may decrease the excretion rate of almasilate, leading to higher serum levels
may increase the nephrotoxic effect
it may enhance the risk of nephrotoxicity when combined with phenylbutazone
the rate of excretion of potassium nitrate may be reduced
cefmetazole might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
Actions and Spectrum:Â
Actions:Â
cefmetazole is a beta lactam second generation cephalosporin antibiotic that has bactericidal activity along with peptidoglycan crosslinking inhibition. The bactericidal activity stops the synthesis of cell wall by interfering which leads to autolysins of bacterial cells that results in the lysis of bacterial cell. Â
Spectrum:Â
cefmetazole shows wide antimicrobial spectrum which shows its activity against gram-positive and gram-negative microbes. Efficacy of its activity is high in many infection types with no serious side effects till date. Main purpose apart from treating urinary tract and skin infections is in the surgical prophylaxis for various bacterial infections in the body.Â
Frequency definedÂ
1 to 10%Â
Nausea(2.5%)Â
Vomiting(3%)Â
Diarrhoea(2.7%)Â
Abdominal pain(3.5%)Â
<1%Â
Rash (0.73%)Â Â
RareÂ
Pseudomembranous colitisÂ
Cholestatic jaundiceÂ
AnaphylaxisÂ
Hypersensitivity hepatitisÂ
Stevens-Johnson syndromeÂ
DermatitisÂ
ThrombocytopeniaÂ
LeukopeniaÂ
AgranulocytosisÂ
AnemiaÂ
EoasinophiliaÂ
HypotensionÂ
ShockÂ
Black Box Warning:Â
Allergic persons to cefmetazole or any cephalosporin drugs should avoid. Monitoring of kidney functions while taking this medication which could warrant a change in the frequency of the dose.
Contraindication/Caution:Â
ContraindicationsÂ
CautionsÂ
Pregnancy consideration:Â Â
No data is available regarding the administration of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of drug in breast milk.Â
Pregnancy category:Â
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: No data is available for the drug under this category.Â
Pharmacology:Â
cefmetazole is a beta lactam class of antibiotic which falls under second generation cephalosporins that interferes with synthesis of bacterial cell wall and blocks the cross linking of peptidoglycan. This acts in a way that bacterial cell goes into lysis which shows it is a bactericidal agent that has strong spectrum which wide including both gram-positive and gram-negative microbes and treats effectively against microorganisms that produces beta lactamase and resistant to first generation cephalosporins.  Â
Pharmacodynamics:Â
Bactericidal activity of cefmetazole is it stops the cell wall synthesis of bacteria and blocks the cross linking of peptidoglycan. This results in the autolysis of the cell of bacteria.Â
Pharmacokinetics:Â
AbsorptionÂ
The bioavailability is 100% after IM.Â
The time to achieve peak effect is 2.5-3 hoursÂ
DistributionÂ
Protein-bound is 65-85%Â
The volume of distribution of cefmetazole is 10 L/kgÂ
MetabolismÂ
The degree of metabolism varies for different cephalosporin antibiotics.Â
Elimination and ExcretionÂ
The half-life is 1-1.5 hoursÂ
The drug is excreted 75% in urine unchanged.Â
Administration:Â
cefmetazole is parenterally administered that is IM of 0.5-1 g twice a day or via slow IV over 3-5 minutes to treat various bacterial infections. Dose and its frequency are generally depends up on prescription of physician and the patient’s condition.
Patient information leafletÂ
Generic Name: cefmetazoleÂ
Why do we use cefmetazole?Â
cefmetazole is a parenteral bactericidal drug administered intravenously or intramuscularly to treat various bacterial infections ranging broadly which includes both gram-positive and gram-negative microbes and used in the surgical prophylaxis for various infections of bacteria.
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