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November 25, 2025
Brand Name :
Diuril
Synonyms :
chlorothiazide
Class :
Diuretics and Thiazide
may enhance the risk of electrolyte imbalance when combined with chlorothiazide
It may enhance the effects when combined with maitake by pharmacodynamic synergism
It may diminish the therapeutic efficacy when combined with pegloticase
It may enhance toxicity when combined with beclomethasone, inhaled by enhancing elimination
It may enhance the effects when combined with vitamin D
It may enhance the effect when combined with tafamidis meglumine
chlorothiazide leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
chlorothiazide: it may increase the risk of hypokalemia with procaterol
chlorothiazide: it may decrease activities of antihypertensive drugs
chlorothiazide: it may decrease activities of antihypertensive drugs
chlorothiazide: it may decrease activities of antihypertensive drugs
chlorothiazide: it may decrease activities of antihypertensive drugs
chlorothiazide: it may decrease activities of antihypertensive drugs
chlorothiazide: it may increase the risk of methemoglobinemia associated agents
chlorothiazide: it may increase the risk of methemoglobinemia associated agents
chlorothiazide: it may increase the risk of methemoglobinemia associated agents
chlorothiazide: it may increase the risk of methemoglobinemia associated agents
chlorothiazide: it may increase the risk of methemoglobinemia associated agents
chlorothiazide may increase the excretion rate of almasilate, potentially lowering serum levels and reducing efficacy
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with chlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
amoxicillin and clavulanate potassium
when amoxicillin combines with chlorothiazide it decreases the effects of the action of drug by decreasing renal clearance
when both drugs are combined, there may be a decreased effect of the drug's action by decreasing renal clearance
it may decrease the serum potassium levels
may decrease the serum potassium levels
may have a decrease in excretion when combined with chlorothiazide
the risk of electrolyte imbalance may be increased
the serum levels of potassium are reduced by chlorothiazide, whereas levels of potassium are increased by aspirin rectal
chlorothiazide increases the effects of nafcillin by decreasing the renal clearance.
chlorthiazide increases the effect of piperacillin by decreasing renal clearance.
glycopyrrolate inhaled and formoterolÂ
may enhance the effects of the other by pharmacodynamic synergism
Adverse drug reactions:  Â
Frequency Not DefinedÂ
Headache Â
Hearing impairment Â
Hyperuricemia Â
Hypocalcemia Â
Anaphylaxis Â
Anemia Â
Anorexia Â
Diarrhea Â
Dizziness Â
Glucose intolerance Â
Glycosuria Â
Pregnancy warnings:    Â
Pregnancy Category: C & DÂ
Breastfeeding warnings: Â
The release of the drug into the human breastmilk is knownÂ
Pregnancy Categories:      Â
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first trimester or the later trimester.      Â
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women      Â
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women      Â
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits      Â
Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.      Â
Category N: There is no data available for the drug under this category
Patient Information Leaflet Â
Generic Name: chlorothiazideÂ
Pronounced: KLOR-oh-THYE-a-zideÂ
Why do we use chlorothiazide?Â
chlorothiazide is a diuretic drug that belongs to the sub-class thiazide used to treat high blood pressure caused by strokes, heart attacks, and kidney diseaseÂ