Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
Revonto, Ryanodex, Dantrium
Synonyms :
dantrolene
Class :
Skeletal Muscle Relaxants
Brand Name :
Revonto, Ryanodex, Dantrium
Synonyms :
dantrolene
Class :
Skeletal Muscle Relaxants
Dosage forms & Strengths:Â
Adult:Â
CapsuleÂ
25 mgÂ
50 mgÂ
100 mgÂ
Powder for Injection Â
20 mg/vialÂ
250mg/vialÂ
Dosage forms & Strengths:Â
CapsuleÂ
25 mgÂ
50 mgÂ
100 mgÂ
Powder for Injection Â
20 mg/vialÂ
250mg/vialÂ
Refer to the adult dosingÂ
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
it increases the effect of hyperkalemia of calcium channel blockers
it increases the effect of hyperkalemia of calcium channel blockers
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
bazedoxifene/conjugated estrogens
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
may have an increased hyperkalemic effect when combined with CCBs
may have an increased hyperkalemic effect when combined with CCBs
estrogen derivatives may potentially amplify the hepatotoxic effect of dantrolene
estrogen derivatives may potentially amplify the hepatotoxic effect of dantrolene
It may diminish the effect when combined with efavirenz affecting CYP3A4 metabolism
The hepatotoxicity of dantrolene might be intensified by Estrogen Derivatives
The hepatotoxicity of dantrolene might be intensified by Estrogen Derivatives
The potential for increased CNS depression risk or seriousness occurs when dantrolene is used together with pinazepam
When dantrolene is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when dantrolene is used together with fencamfamin
When dantrolene is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When chlordiazepoxide is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
When dantrolene is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
Actions and Spectrum:Â
dantrolene is a medication used to relax muscles and reduce muscle spasms.
Frequency undefined:Â
DiarrheaÂ
AnorexiaÂ
Gastric irritationÂ
NauseaÂ
GI bleedingÂ
DysphagiaÂ
Speech disturbance Â
Visual disturbancesÂ
DysgeusiaÂ
Adynamic ileusÂ
DroolingÂ
InsomniaÂ
NocturiaÂ
DrowsinessÂ
Acneiform rashÂ
PruritisÂ
SweatingÂ
Difficult irritationÂ
Heart failureÂ
TachycardiaÂ
LymphomaÂ
Respiratory depressionÂ
Black Box Warning:Â
It is essential to follow the dosage and administration instructions for dantrolene carefully, as an overdose can cause serious side effects.Â
Contraindication/Caution:Â
dantrolene should not be used in people hypersensitive to the drug itself.Â
Pregnancy consideration:Â Â
Insufficient data is available regarding the use of the drug during pregnancy.Â
Breastfeeding warnings:Â Â
Breastfeeding should not be performed during drug administration.Â
Pregnancy category:Â
PharmacologyÂ
It works by inhibiting the release of calcium ions from the sarcoplasmic reticulum in muscle cells, which decreases muscle contraction.Â
Pharmacodynamics:Â
The pharmacodynamic effects of dantrolene are specific to skeletal muscle cells. They do not affect other tissues or organs in the body. Pharmacokinetics:Â
dantrolene is highly protein-bound and has a large volume of distribution, which means that it is widely distributed throughout the body. It is not significantly metabolized by the cytochrome P450 enzyme system and has no known drug interactions.Â
DistributionÂ
After it is absorbed from the gastrointestinal tract, dantrolene is distributed throughout the body. It is highly protein-bound and has a large volume of distribution, which means that it is widely distributed throughout the body.Â
MetabolismÂ
The metabolism of dantrolene occurs primarily in the liver. There it is metabolized into several active and inactive metabolites. Â
Elimination and excretionÂ
These metabolites are then eliminated from the body through the kidneys and feces.Â
Administration:Â
The dantrolene is administered through the intravenous route.Â
Patient information leafletÂ
Generic Name: dantroleneÂ
Pronounced: dan-tro-leenÂ
Why do we use dantrolene?Â
dantrolene treats malignant hyperthermia, spasticity, and neuroplastic malignant syndrome. Â
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