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Brand Name :
Revonto, Ryanodex, Dantrium
Synonyms :
dantrolene
Class :
Skeletal Muscle Relaxants
Brand Name :
Revonto, Ryanodex, Dantrium
Synonyms :
dantrolene
Class :
Skeletal Muscle Relaxants
Dosage forms & Strengths:
Adult:
Capsule
25 mg
50 mg
100 mg
Powder for Injection
20 mg/vial
250mg/vial
Dosage forms & Strengths:
Capsule
25 mg
50 mg
100 mg
Powder for Injection
20 mg/vial
250mg/vial
Refer to the adult dosing
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
may have an increased hyperkalemic effect when combined with calcium channel blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
May enhance the hyperkalemic effect when combined with Calcium Channel Blockers
it increases the effect of hyperkalemia of calcium channel blockers
it increases the effect of hyperkalemia of calcium channel blockers
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
bazedoxifene/conjugated estrogens
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
estrogen derivatives can enhance the hepatotoxic effect of dantrolene
may have an increased hyperkalemic effect when combined with CCBs
may have an increased hyperkalemic effect when combined with CCBs
estrogen derivatives may potentially amplify the hepatotoxic effect of dantrolene
estrogen derivatives may potentially amplify the hepatotoxic effect of dantrolene
It may diminish the effect when combined with efavirenz affecting CYP3A4 metabolism
The hepatotoxicity of dantrolene might be intensified by Estrogen Derivatives
The hepatotoxicity of dantrolene might be intensified by Estrogen Derivatives
The potential for increased CNS depression risk or seriousness occurs when dantrolene is used together with pinazepam
When dantrolene is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with medazepam, the risk or seriousness of CNS depression is enhanced
The potential for CNS depression may enhanced when dantrolene is used together with fencamfamin
When dantrolene is used together with niaprazine, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When dantrolene is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When chlordiazepoxide is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
When dantrolene is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
When emylcamate is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
When acepromazine is used together with dantrolene, this leads to enhanced risk or seriousness of CNS depression
Actions and Spectrum:
dantrolene is a medication used to relax muscles and reduce muscle spasms.
Frequency undefined:
Diarrhea
Anorexia
Gastric irritation
Nausea
GI bleeding
Dysphagia
Speech disturbance
Visual disturbances
Dysgeusia
Adynamic ileus
Drooling
Insomnia
Nocturia
Drowsiness
Acneiform rash
Pruritis
Sweating
Difficult irritation
Heart failure
Tachycardia
Lymphoma
Respiratory depression
Black Box Warning:
It is essential to follow the dosage and administration instructions for dantrolene carefully, as an overdose can cause serious side effects.
Contraindication/Caution:
dantrolene should not be used in people hypersensitive to the drug itself.
Pregnancy consideration:
Insufficient data is available regarding the use of the drug during pregnancy.
Breastfeeding warnings:
Breastfeeding should not be performed during drug administration.
Pregnancy category:
Pharmacology
It works by inhibiting the release of calcium ions from the sarcoplasmic reticulum in muscle cells, which decreases muscle contraction.
Pharmacodynamics:
The pharmacodynamic effects of dantrolene are specific to skeletal muscle cells. They do not affect other tissues or organs in the body. Pharmacokinetics:
dantrolene is highly protein-bound and has a large volume of distribution, which means that it is widely distributed throughout the body. It is not significantly metabolized by the cytochrome P450 enzyme system and has no known drug interactions.
Distribution
After it is absorbed from the gastrointestinal tract, dantrolene is distributed throughout the body. It is highly protein-bound and has a large volume of distribution, which means that it is widely distributed throughout the body.
Metabolism
The metabolism of dantrolene occurs primarily in the liver. There it is metabolized into several active and inactive metabolites.
Elimination and excretion
These metabolites are then eliminated from the body through the kidneys and feces.
Administration:
The dantrolene is administered through the intravenous route.
Patient information leaflet
Generic Name: dantrolene
Pronounced: dan-tro-leen
Why do we use dantrolene?
dantrolene treats malignant hyperthermia, spasticity, and neuroplastic malignant syndrome.
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