Microplastics and Misinformation: What Science Really Says
November 12, 2025
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Brand Name :
N/A
Synonyms :
dihydrocodeine
Class :
Opioid analgesic
Brand Name :
N/A
Synonyms :
dihydrocodeine
Class :
Opioid analgesic
Tablet
30mg
40mg
30
mg
Tablet
Oral
Off-label
Off-label:
30 - mg
Tablets
Oral
3 - 4 times a day
Do not exceed 180mg (6 tablets) a day
Tablet
30mg
40 mg
Pain:
Age: > 12 years
Refer to adult dosing
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
may increase the toxic effect when combined
it may diminish the therapeutic efficacy when combined with castor oil
When dihydrocodeine is used together with bromisoval, the risk or seriousness of CNS depression is enhanced
When dihydrocodeine is used together with levosulpiride, the risk or seriousness of CNS depression is enhanced
When dihydrocodeine is used together with melitracen, this leads to enhanced risk or seriousness of CNS depression
the serum levels of dihydrocodeine may be increased with abametapir
the rate of metabolism of dihydrocodeine may be decreased
the risk of depression of the central nervous system can be enhanced when dihydrocodeine is taken with acetazolamide
the risk of depression in the central nervous system can be enhanced when dihydrocodeine is taken with asenapine
the CNS depressant activity of azelastine may be decreased with dihydrocodeine
the risk of CNS depression may be increased
the rate of metabolism of dihydrocodeine may be reduced
the rate of metabolism of dihydrocodeine may be reduced
the risk of CNS depression may be reduced
the risk of CNS depression may be increased
the rate of metabolism of dihydrocodeine may be reduced
the risk of CNS depression may be increased
When indisulam is used together with dihydrocodeine, this leads to a reduction in dihydrocodeine metabolism
When dihydrocodeine is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
Actions and spectrum:
Dihydromorphine, an active metabolite of dihydrocodeine, has a high affinity for mu-type opioid receptors
Black Box Warning
Do not drive vehicles or operate machines
Contraindication/Caution:
Contraindication:
Renal impairment
Hepatic impairment
Pregnancy consideration:
USFDA pregnancy category: C
Lactation:
The exact excretion of dihydrocodeine into breast milk is not known.
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Pharmacodynamics:
Pharmacokinetics:
Absorption
Poor gastrointestinal absorption when administered orally
Distribution
Metabolism
Dihydrocodeine is metabolized in the liver to dihydromorphine, which is an active metabolite, followed by nordihydrocodeine, a secondary metabolite, and dihydrocodeine-6-glucuronide, a third metabolite.
Elimination and excretion
Dihydrocodeine is mainly eliminated through urine.
Half-life:
4hours
Administration:
Administered orally
Patient information leaflet
Generic Name: dihydrocodeine
Why do we use dihydrocodeine?
Dihydrocodeine is an opioid analgesic used in the treatment of dry cough. As an alternative to codeine, it is used in treating severe dyspnea, pain, and cough.
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