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Brand Name :
HEY FORTE
Synonyms :
idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
Class :
Antioxidants
Brand Name :
HEY FORTE
Synonyms :
idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
Class :
Antioxidants
Dosage forms and strengths
HEYFORTE capsule
Idiopathic Oligo Asthenospermia
Take one capsule three times a day for ninety days to complete the course, or follow the instructions provided by your healthcare provider
Not indicated
Refer adult dosing
Actions and Spectrum:
Action:
idebenone is a synthetic coenzyme Q10 (CoQ10) analog primarily known for its antioxidant properties.
l-arginine
l-arginine is vital in numerous physiological processes as an essential amino acid. It is a precursor to nitric oxide (NO).
zinc sulphate
zinc constitutes a critical mineral essential for numerous enzymatic reactions, supporting immune system functionality and facilitating the process of wound healing. zinc sulphate is a standard zinc supplementation used to address zinc deficiency.
selenium is an essential trace element cofactor for various enzymes, including those with antioxidant properties.
proanthocyanidin
proanthocyanidins are a group of polyphenolic compounds found in many plants, including grapes, berries, and certain tree barks. They are known for their antioxidant properties and may have various health benefits, including supporting cardiovascular health and reducing inflammation.
Spectrum
idebenone primarily acts as an antioxidant, targeting free radicals and oxidative stress. Its spectrum of action is particularly relevant in conditions where oxidative damage plays a significant role, such as neurodegenerative disorders and skin aging.
l-arginine
l-arginine’s actions include vasodilation through no production, protein synthesis and tissue repair support, and immune system modulation. It is often used as a dietary supplement to address various health concerns.
zinc sulphate
zinc sulphate supports immune system function, DNA synthesis, and wound healing, among other functions.
selenium
selenium primarily acts as an antioxidant, aiding the defense against oxidative stress.
proanthocyanidins
proanthocyanidins primarily act as antioxidants, helping to neutralize free radicals and reduce oxidative stress. They also have potential anti-inflammatory properties, making them beneficial for various health conditions.
Frequency not defined
Dizziness
Bloating
Allergies
Blood abnormalities
Dizziness
Gastrointestinal disturbances
Black Box Warning:
None
Contraindication/Caution:
Allergic Reactions: People who have allergies to any of these substances should avoid using this combination.
Pregnancy and Breastfeeding: Expectant and breastfeeding mothers should take caution or refrain from using these substances, as their safety during these periods may not be well-established.
Age & Children: Some of these substances may not be suitable for children, and dosages should be carefully regulated in older adults. It is essential to seek guidance from a medical expert for suitable advice.
Surgery: Some substances may affect blood clotting or blood pressure, which can be essential considerations before surgery. Inform your surgeon about any supplements you are taking.
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
idebenone is a synthetic analog of coenzyme Q10 (CoQ10) with antioxidant properties. l-arginine plays a crucial role as a precursor in nitric oxide production. zinc, a crucial trace element, plays a significant role in numerous enzymatic reactions and cellular processes. selenium is another essential trace element and is a component of selenoproteins, which have antioxidant and enzymatic functions. proanthocyanidins are a group of polyphenolic compounds found in various plant sources, such as grapes and pine bark.
Pharmacodynamics:
idebenone
idebenone functions as a coenzyme Q10 (CoQ10) analogue and is involved in mitochondrial electron transport chain activity.
idebenone helps improve cellular energy production by supporting ATP synthesis.
l-arginine
l-arginine is an amino acid crucial in producing nitric oxide (NO).
NO is a vasodilator, which relaxes blood vessels and improves blood flow.
l-arginine is often a dietary supplement to support cardiovascular health and enhance exercise performance.
zinc sulphate
zinc is an essential mineral cofactor for numerous enzymes and transcription factors in the body.
zinc sulphate is commonly used as a dietary supplement to address zinc deficiency.
selenium
selenium is an essential trace element cofactor for selenoproteins, many of which have antioxidant properties.
It assists in safeguarding cells against oxidative harm and functions in regulating thyroid hormone metabolism.
proanthocyanidin
proanthocyanidins are a group of polyphenolic compounds found in various plants, particularly grapes, pine bark, and certain fruits.
They are potent antioxidants and have been studied for their potential benefits in protecting cells from oxidative stress.
Pharmacokinetics:
Absorption
idebenone is orally administered and is absorbed in the gastrointestinal tract.
the small intestine efficiently takes up l-arginine.
zinc sulphate is well absorbed in the gastrointestinal tract.
selenium is absorbed in the small intestine.
proanthocyanidins are absorbed in the small intestine after consuming foods or supplements rich in these compounds.
Distribution
idebenone has good tissue penetration and crosses the blood-brain barrier. It is distributed widely throughout the body.
l-arginine is distributed throughout the body and is involved in various metabolic pathways.
zinc is distributed to various tissues, with the highest concentrations found in the muscles, bones, and liver.
selenium is distributed to various tissues, with higher concentrations in the liver and kidneys.
proanthocyanidins are distributed throughout the body and have antioxidant properties.
Metabolism
idebenone undergoes hepatic metabolism, primarily through the cytochrome P450 enzyme system.
l-arginine is metabolized in the liver and kidneys.
zinc is not significantly metabolized in the body.
selenium is metabolized in the liver and converted into various selenoproteins.
proanthocyanidins are metabolized by gut microbiota to produce more minor phenolic compounds.
Excretion and Elimination
The metabolites of idebenone are excreted primarily in the urine.
Metabolites of l-arginine, including urea and ornithine, are excreted in the urine.
Excess zinc is primarily excreted through the urine.
selenium is excreted primarily in the urine.
The Metabolites of proanthocyanidin are eliminated through both urinary and fecal excretion.
Administration:
If taking these supplements together, consult medical professional who can evaluate the specific health requirements and deficiencies and identify any potential interactions or contraindications. They can guide appropriate dosages and duration of use and monitor your progress to ensure your safety and well-being.
Patient information leaflet
Generic Name: idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin
Why do we use idebenone / l-arginine / zinc sulphate/selenium/proanthocyanidin?
idebenone, l-arginine, zinc sulfate, selenium, and proanthocyanidin all possess antioxidant properties. They can work together to neutralize harmful free radicals in the body, reducing oxidative stress and protecting cells from damage.
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