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Brand Name :
Isepacine
Synonyms :
isepamicin
Class :
Antibiotic, Aminoglycoside
Brand Name :
Isepacine
Synonyms :
isepamicin
Class :
Antibiotic, Aminoglycoside
Dosage Forms & Strengths
Solution
100 mg/ml
Administer daily dose of 400 mg intramuscularly or intravenously in 1 to 2 divided doses
Not determined
Refer to adult dosing
alclofenac: it may decrease the excretion rate of isepamicin
aldesleukin: it may decrease the excretion rate of isepamicin
allopurinol: it may decrease the excretion rate of isepamicin
almasilate: it may decrease the excretion rate of isepamicin
almotriptan: it may decrease the excretion rate of isepamicin
bethanechol: it may decrease the therapeutic efficacy of isepamicin
bicisate: it may decrease the excretion rate of isepamicin
bismuth subgallate: it may decrease the excretion rate of isepamicin
bisoprolol: it may decrease the excretion rate of Isepamicin
bisoxatin: it may decrease the excretion rate of isepamicin
cefpiramide: it may decrease the excretion rate of isepamicin
cefpirome: it may decrease the excretion rate of isepamicin
cefpodoxime: it may decrease the excretion rate of isepamicin
cefprozil: it may decrease the excretion rate of isepamicin
cefradine: it may decrease the excretion rate of isepamicin
ceftazidime: it may decrease the excretion rate of isepamicin
Actions and Spectrum
isepamicin works by inhibiting bacterial protein synthesis. It binds to the 30S ribosomal subunit of bacterial ribosomes, which are essential for the synthesis of bacterial proteins.
Frequency not defined
Ototoxicity
Respiratory depression
Muscular paralysis
Nephrotoxicity
Electrolyte disturbances
Black Box Warning
None
Contraindication/Caution:
None
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
isepamicin disrupts the process of protein synthesis, ultimately leading to the death of the bacterial cells. This mechanism of action is bactericidal, meaning it kills the bacteria rather than just inhibiting their growth.
Pharmacodynamics
isepamicin can exhibit a post-antibiotic effect, which is the continued suppression of bacterial growth even after the drug has been eliminated from the body.
Pharmacokinetics
Absorption
isepamicin has low oral bioavailability and it is poorly absorbed from the gastrointestinal tract.
Distribution
isepamicin having small volume of distribution in body.
Metabolism
isepamicin is not significantly metabolized in the body.
Elimination and excretion
isepamicin is excreted through the kidneys.
Administration
isepamicin is administered through intravenous (IV) or intramuscular (IM) routes.
Patient information leaflet
Generic Name: isepamicin
Why do we use isepamicin?
isepamicin is an antibiotic that is used to treat various bacterial infections.
isepamicin may be used for the treatment of systemic infections, such as septicemia.
isepamicin is also used to treat UTIs caused by susceptible Gram-negative bacteria.
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