Effectiveness of Tai Chi vs Cognitive Behavioural Therapy for Insomnia in Middle-Aged and Older Adults
November 27, 2025
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Brand Name :
Ixempra
Synonyms :
ixabepilone
Class :
Antineoplastics, Antimicrotubular; Antineoplastics, Epothilone B Analog
Brand Name :
Ixempra
Synonyms :
ixabepilone
Class :
Antineoplastics, Antimicrotubular; Antineoplastics, Epothilone B Analog
Dosage forms & Strengths:Â
Adult:Â
Powder for InjectionÂ
15 mg/vialÂ
45 mg/vialÂ
40
mg/m²
Intravenous (IV)
over 3 hr
3
week
Do not exceed 88 mg daily
Safety and efficacy are not seen in pediatricsÂ
Refer to the adult dosingÂ
may enhance the serum concentration of CYP3A4 Inhibitors
It may increase the CNS depressant effect when combined with CNS Depressants
CYP3A strong enhancers of the small intestine may reduce the bioavailability of ixabepilone
may enhance the serum concentration of CYP3A4 Inhibitors
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressive effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
may have an increased CNS depressant effect when combined with CNS depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
may enhance the concentration of serum when combined with ixabepilone
may enhance the concentration of serum when combined with ixabepilone
may enhance the concentration of serum when combined with ixabepilone
may enhance the concentration of serum when combined with ixabepilone
may enhance the concentration of serum when combined with ixabepilone
ixabepilone: they may enhance the serum concentration of CYP3A Inhibitors
ixabepilone: they may enhance the serum concentration of CYP3A Inhibitors
ixabepilone: they may enhance the serum concentration of CYP3A Inhibitors
ixabepilone: they may enhance the serum concentration of CYP3A Inhibitors
ixabepilone: they may enhance the serum concentration of CYP3A Inhibitors
it may enhance the metabolism when combined with oxcarbazepine
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
ixabepilone: they may increase the CNS depressant effect of CNS Depressants
the effect of ixabepilone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
may decrease the serum concentration
may enhance the serum concentration of CYP3A4 inhibitors
- may increase the CNS depressant effect of CNS depressants
may increase the CNS depressant effect of CNS depressants
may enhance the serum concentration of CYP3A4 Inhibitors
Actions and Spectrum:Â
ixabepilone is a microtubule-stabilizing agent and a type of chemotherapy drug. It inhibits cell division and disrupts necessary microtubules for cell growth and division. Ixabepilone is used to treat advanced or metastatic breast cancer that has become resistant to other forms of chemotherapy.Â
>10%:Â
Asthenia (63%)Â
Neuropathy (63%)Â
Alopecia (48%)Â
Nausea (42%)Â
Vomiting (29%)Â
Anorexia (19%)Â
Diarrhea (22%)Â
1-10%:Â
Hand-foot syndrome (8%)Â
Nail changes (9%)Â
Neutropenia (3%)Â
Black Box Warning:Â
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindication/Caution:Â
ixabepilone should not be used in people hypersensitive to the drug itself.Â
Pregnancy consideration:Â Â
ixabepilone is not recommended during pregnancy.Â
Breastfeeding warnings:Â Â
No data is available regarding the presence of the drug in human breast milk.Â
Pregnancy category:Â
PharmacologyÂ
ixabepilone is a microtubule-stabilizing agent. It belongs to the class of drugs known as epothilones. It works by binding to tubulin, a protein that makes up microtubules, and stabilizing them. It prevents the normal breakdown of microtubules during cell division, leading to cell cycle arrest and apoptosis (programmed cell death) of cancer cells. Â
Pharmacodynamics:Â
The drug is active in preclinical breast, ovarian, and lung cancer models and in models of taxane resistance.Â
Ixabepilone has also been found to have the ability to overcome resistance to taxanes and anthracyclines by inhibiting multidrug resistance (MDR) pumps, which are responsible for the efflux of drugs out of cancer cells, leading to drug resistance. Pharmacokinetics:Â
ixabepilone is administered intravenously (IV) and has a good bioavailability after IV administration. The drug is rapidly distributed in the body. Â
AbsorptionÂ
The peak plasma time is 3 hours.Â
The bound protein value is 67-77%. Â
DistributionÂ
After IV administration, ixabepilone is distributed to other organs. Its volume of distribution is more than 1000L.Â
MetabolismÂ
ixabepilone is primarily metabolized by the CYP3A4 enzyme, which is found in the liver and gut. The primary metabolite of ixabepilone is lactone, which is pharmacologically inactive. Â
Elimination and excretionÂ
ixabepilone has an elimination half-life of about 52 hours.
Administration:Â
Store the kit under refrigeration. Thaw for 30 minutes before using. Use a 0.2-1.2-microns inline filter. Â
Patient information leafletÂ
Generic Name: ixabepiloneÂ
Pronounced: ik-sa-bep-i-loneÂ
Why do we use ixabepilone?Â
ixabepilone has antineoplastic properties. It helps treat breast cancer.  Â
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