Genomic Study Maps Shared Risk Factors for 14 Psychiatric Disorders
December 14, 2025
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Brand Name :
harvoni
Synonyms :
ledipasvir/sofosbuvir
Class :
Hepatitis C virus polymerase inhibitors
Brand Name :
harvoni
Synonyms :
ledipasvir/sofosbuvir
Class :
Hepatitis C virus polymerase inhibitors
Dosage Forms & Strengths
Tablet
45mg/200mg
90mg/400mg
<3 years: Safety and efficacy not established
>3 years:
<17kgs: 1 tablet (33.75mg/150mg) of pellets orally every day
17 to <35kg: 1 tablet (45mg/200mg) of pellets orally every day
>35kgs:1 tablet(90mg/400mg) orally everyday or 2 tablet(45mg/200mg) orally everyday
may enhance the serum concentration of P-glycoprotein/ABCB1 Inhibitors
may increase the bradycardic effect
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may diminish the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may decrease the serum concentration
may diminish the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
Frequency defined:
>10%
Fatigue
Cough
Asthenia
Headache
1-10%
Diarrhea
Dyspnoea
Increased bilirubin >1.5 X ULN
Myalgia
Nausea
Dizziness
Insomnia
Increased lipase >3 X ULN
Irritability
Post-marketing reports
Skin rash
Bradycardia
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: ledipasvir/sofosbuvir
Pronounced: [ le-DIP-as-vir-and-soe-FOS-bue-vir ]
Why do we use ledipasvir/sofosbuvir?
It is used to treat hepatitis C in adults
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