Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Xenleta
Synonyms :
lefamulin
Class :
Miscellaneous antibiotic
Brand Name :
Xenleta
Synonyms :
lefamulin
Class :
Miscellaneous antibiotic
Dosage Forms & Strengths Â
Tablet Â
600mg Â
solution Â
150mg/15mL 0.9% NaCl  Â
Indicated for Community Acquired Bacterial Pneumonia (CABP)
150 mg IV 2 times a day for 5-7 days
or
600 mg orally 2 times a day for 5 days
Safety and efficacy not establishedÂ
lefamulin: they may diminish the serum concentration of CYP3A4 Inducers
lefamulin: they may diminish the serum concentration of CYP3A4 Inducers
lefamulin: they may diminish the serum concentration of CYP3A4 Inducers
lefamulin: they may diminish the serum concentration of CYP3A4 Inducers
lefamulin: they may diminish the serum concentration of CYP3A4 Inducers
may diminish the concentration of serum when combined with lefamulin
may diminish the concentration of serum when combined with lefamulin
lefamulin: they may enhance the serum concentration of glycoprotein IIb Inhibitors
when both drugs are combined, there may be an increased level or effect of romidepsin by affecting hepatic or intestinal enzyme cyp3a4 metabolism  
lefamulin increases the effect of lapatinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
when both drugs are combined, there may be an increase in the effect of crizotinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
it increases the effect or level of osimertinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may enhance the serum concentration of P-glycoprotein inhibitors
may enhance the serum concentration of P-glycoprotein/ABCB1 Inhibitors
lefamulin and loperamide are both known to elevate the QTc interval
QTc interval increases on taking lefamulin and lenvatinib together. Avoid or take an alternate drug
the effect of imatinib is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of lefamulin 
when used together, entrectinib and lefamulin both increase the QTc interval
when used together, encorafenib and lefamulin both increase the QTc interval
it increases the effect of QTc-prolongation in QT-prolonging CYP3A4 substrates
may increase the QTc interval when combined
when both drugs are combined, there may be an increased level of serum concentration of etoposide   
when both drugs are combined, there may be an increased level of serum concentration of vinblastine  
fedratinib increases the effect of lefamulin by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
it increases the QT-c prolonging effect of gilteritinib
metronidazole enhances the effect of lefamulin by altering the intestinal or hepatic CYP3A4 enzyme metabolism
Adverse drug reactions Â
Frequency Defined Â
>10% Â
Diarrhea (12%) Â
1-10% Â
Nausea (3-5%) Â
Hypokalemia (3%) Â
Insomnia (3%) Â
Vomiting (3%) Â
Hepatic enzyme elevation (2-3%) Â
Headache (2%) Â
<2% Â
Thrombocytopenia Â
Atrial fibrillation Â
Pregnancy warnings:   
US FDA pregnancy category: Not assigned.Â
Lactation: Â
The drug excretion in breastmilk is unknown. Â
Pregnancy Categories:       Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were no enough studies on pregnant women. Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category Â
Patient Information Leaflet  Â
Generic Name: lefamulinÂ
Why do we use lefamulin? Â
lefamulin is a Miscellaneous antibiotic used to treat certain types of pneumonia.Â
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