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Brand Name :
Loxomac
Synonyms :
loxoprofen
Class :
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Dosage Forms & Strengths
Tablet
60 mg
Take a dose of 60 mg orally three times a day or 120 mg as a single daily dose
Not determined
Refer to adult dosing
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
NSAIDS may enhance the neuroexcitatory and/or seizure-potentiating effect of quinolones
Corticosteroids may enhance the adverse/toxic effect of nonsteroidal Anti-Inflammatory agents
Corticosteroids may enhance the adverse/toxic effect of nonsteroidal Anti-Inflammatory agents
Corticosteroids may enhance the adverse/toxic effect of nonsteroidal Anti-Inflammatory agents
Corticosteroids may enhance the adverse/toxic effect of nonsteroidal Anti-Inflammatory agents
Corticosteroids may enhance the adverse/toxic effect of nonsteroidal Anti-Inflammatory agents
When loxoprofen is used together with sertraline, the risk or seriousness of bleeding may be enhanced
When loxoprofen is used together with bufexamac, this leads to enhanced risk or seriousness of adverse outcomes
loxoprofen leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When loxoprofen is used together with nifenazone, this leads to enhanced risk or seriousness of adverse events
When loxoprofen is used together with diazoxide, this leads to reduction in therapeutic effectiveness of diazoxide
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
angiotensin-Converting Enzyme Inhibitors may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents
may increase the risk or severity of hypertension when combined
Actions and Spectrum
The cyclooxygenase inhibitor loxoprofen is non-selective. Prostaglandins are made from arachidonic acid hence it reduces that process. It is a prodrug that, when administered orally, quickly changes into its active metabolite.
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
loxoprofen is an NSAID commonly used to alleviate pain and inflammation. The mechanism of action involves inhibiting COX enzymes, which reduces the production of prostaglandins.
Pharmacodynamics
The inhibition of prostaglandin synthesis results in a reduction in pain. loxoprofen’s analgesic effects make it effective for managing various types of pain, ranging from musculoskeletal pain to dental pain.
Pharmacokinetics
Absorption
loxoprofen is rapidly absorbed from the gastrointestinal tract after.
Distribution
loxoprofen has a moderate degree of plasma protein binding.
Metabolism
loxoprofen undergoes metabolism primarily in the liver through oxidation.
Elimination and excretion
loxoprofen and its metabolites are primarily excreted in the urine.
Administration
loxoprofen is administered orally in the form of tablets.
Patient information leaflet
Generic Name: loxoprofen
Why do we use loxoprofen?
loxoprofen is used to manage pain and inflammation caused by acute injuries, such as sprains and strains.
loxoprofen can be prescribed to manage postoperative pain and inflammation.
loxoprofen is indicated to relieve pain and inflammation associated with musculoskeletal disorders.
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