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Brand Name :
Aquatensen, Enduron
Synonyms :
methyclothiazide
Class :
Diuretics, Thiazide
Brand Name :
Aquatensen, Enduron
Synonyms :
methyclothiazide
Class :
Diuretics, Thiazide
Dosage forms and strengthsÂ
tabletÂ
(5mg)Â
(2.5mg)Â
Initial dose is 2.5 mg taken orally daily
dose may be adjusted upwards if necessary
dose should not exceed 10 mg taken orally daily
Safety and efficacy are not establishedÂ
Refer adult DosingÂ
spironolactone and hydrochlorothiazide
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may enhance the toxic effects of the other by pharmacodynamic synergism
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the adverse or toxic effect of anti-psychotic agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
may increase the risk of adverse effect
It may enhance the effects when combined with vitamin D
lansoprazole amoxicillin and clarithromycin
when amoxicillin combines with methyclothiazide it decreases the effects of the action of drug by decreasing renal clearance
amoxicillin and clavulanate potassium
when amoxicillin combines with methyclothiazide it decreases the effects of the action of drug by decreasing renal clearance
omeprazole amoxicillin and clarithromycin
when both drugs are combined, there may be a decrease effect of the drug's action by decreasing renal clearance
may lead to increased myelosuppression
may lead to increased myelosuppression
when both drugs are combined, there may be an increased effect of methyclothiazide by acidic (anionic) drug competition for renal tubular clearance 
Actions and Spectrum:Â Â
methyclothiazide is a thiazide diuretic that inhibits sodium reabsorption in the DCT of the kidneys. The drug primarily treats hypertension and edema associated with congestive heart failure. The spectrum of methyclothiazide is primarily focused on its action as a diuretic.
It effectively increases the excretion of sodium and water from the body, which can help reduce fluid accumulation in conditions such as congestive heart failure, liver disease, and kidney disease. The drug also treats hypertension by reducing blood volume and blood pressure.Â
Frequency not defined Â
Gastrointestinal: sialadenitis, vomiting, diarrhea, nausea, Pancreatitis, jaundice, gastric irritation, constipation, anorexia Â
Body as a whole: weakness, Headache, crampingÂ
Metabolic and Nutritional Disorders: electrolyte imbalance, hyperuricemia, hyperglycemia Â
Cardiovascular: Orthostatic hypotension Â
Hematologic: agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia, Â
Aplastic anemia  Â
Hypersensitivity Reactions: respiratory distress photosensitivity pneumonitis and pulmonary edema, fever, purpura, urticaria, rash, Anaphylactic reactions, necrotizing angiitis Stevens-Johnson syndrome
Black Box Warning:Â Â
The black box warning for methyclothiazide warns about the risk of electrolyte imbalance, particularly low potassium levels (hypokalemia), which can lead to serious cardiac arrhythmiasÂ
Contraindication/Caution:Â Â
The drug is contraindicated in conditions like:Â Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology:
methyclothiazide is a thiazide diuretic medication that increases the excretion of sodium & chloride in the urine, thereby reducing the amount of fluid in the body.Â
Pharmacodynamics:Â Â
The pharmacodynamic mechanism of the drug involves its ability to increase urine output and decrease blood volume by blocking the reabsorption of sodium and chloride ions in the renal tubules.Â
Pharmacokinetics:Â
AbsorptionÂ
The drug gets absorbed efficiently after oral administration and reaches peak plasma concentrations within 2-3 hoursÂ
DistributionÂ
The drug is highly protein-bound (over 95%) and has a large volume of distribution. It crosses the placental barrier and is excreted in breast milk. Â
MetabolismÂ
The drug is minimally metabolized in the liver and undergoes little or no biotransformation. It is primarily eliminated unchanged in the urine. Â
Elimination and ExcretionÂ
The drug is primarily excreted through kidneys. It has a half-life of about 6-10 hours in healthy individuals but may be prolonged in patients with renal impairment.
Administration: Â
It is typically taken orally once daily, preferably in the morning, with or without food. Patients should not adjust the dose or stop taking this drug without consulting their healthcare provider, as sudden discontinuation can lead to a sudden increase in blood pressure or other adverse effects.
Patient information leafletÂ
Generic Name: methyclothiazideÂ
Why do we use methyclothiazide? Â
Hypertension: The drug is commonly used to treat high blood pressure. Â
Edema: The drug can treat edema caused by certain medical conditions such as liver disease, congestive heart failure, and kidney disease. Â
Diabetes insipidus: The drug is also used to treat diabetes insipidus, a condition characterized by excessive thirst and excretion of large amounts of diluted urine. Â
Calcium nephrolithiasis: The drug can be used to reduce the risk of calcium nephrolithiasis, a condition where calcium stones form in the kidneys.Â
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