methyclothiazide

medtigo

methyclothiazide

Brand Name :

Aquatensen, Enduron

Synonyms :

methyclothiazide

Class :

Diuretics, Thiazide

Action and Spectrum

Actions and Spectrum:

methyclothiazide is a thiazide diuretic that inhibits sodium reabsorption in the DCT of the kidneys. The drug primarily treats hypertension and edema associated with congestive heart failure. The spectrum of methyclothiazide is primarily focused on its action as a diuretic.

It effectively increases the excretion of sodium and water from the body, which can help reduce fluid accumulation in conditions such as congestive heart failure, liver disease, and kidney disease. The drug also treats hypertension by reducing blood volume and blood pressure.

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency not defined

Gastrointestinal: sialadenitis, vomiting, diarrhea, nausea, Pancreatitis, jaundice, gastric irritation, constipation, anorexia

Body as a whole: weakness, Headache, cramping

Metabolic and Nutritional Disorders: electrolyte imbalance, hyperuricemia, hyperglycemia

Cardiovascular: Orthostatic hypotension

Hematologic: agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia,

Aplastic anemia

Hypersensitivity Reactions: respiratory distress photosensitivity pneumonitis and pulmonary edema, fever, purpura, urticaria, rash, Anaphylactic reactions, necrotizing angiitis Stevens-Johnson syndrome

Black Box Warning

Black Box Warning:

The black box warning for methyclothiazide warns about the risk of electrolyte imbalance, particularly low potassium levels (hypokalemia), which can lead to serious cardiac arrhythmias

Contraindication / Caution

Contraindication/Caution:

The drug is contraindicated in conditions like:

Hypersensitivity to methyclothiazide or any of its components
Anuria
Severe renal impairment
Hepatic encephalopathy
Electrolyte imbalance

Pregnancy / Lactation

Pregnancy warnings:   

Pregnancy category: N/A

Lactation: Excreted into human milk is unknown

Pregnancy Categories:        

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in the first or second trimester.

<b>Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

methyclothiazide is a thiazide diuretic medication that increases the excretion of sodium & chloride in the urine, thereby reducing the amount of fluid in the body.

Pharmacodynamics:

The pharmacodynamic mechanism of the drug involves its ability to increase urine output and decrease blood volume by blocking the reabsorption of sodium and chloride ions in the renal tubules.

Pharmacokinetics:

Absorption

The drug gets absorbed efficiently after oral administration and reaches peak plasma concentrations within 2-3 hours

Distribution

The drug is highly protein-bound (over 95%) and has a large volume of distribution. It crosses the placental barrier and is excreted in breast milk.

Metabolism

The drug is minimally metabolized in the liver and undergoes little or no biotransformation. It is primarily eliminated unchanged in the urine.

Elimination and Excretion

The drug is primarily excreted through kidneys. It has a half-life of about 6-10 hours in healthy individuals but may be prolonged in patients with renal impairment.

Adminstartion

Administration: 

It is typically taken orally once daily, preferably in the morning, with or without food. Patients should not adjust the dose or stop taking this drug without consulting their healthcare provider, as sudden discontinuation can lead to a sudden increase in blood pressure or other adverse effects.

Patient Information Leaflet

Patient information leaflet

Generic Name: methyclothiazide

Why do we use methyclothiazide?

Hypertension: The drug is commonly used to treat high blood pressure.

Edema: The drug can treat edema caused by certain medical conditions such as liver disease, congestive heart failure, and kidney disease.

Diabetes insipidus: The drug is also used to treat diabetes insipidus, a condition characterized by excessive thirst and excretion of large amounts of diluted urine.

Calcium nephrolithiasis: The drug can be used to reduce the risk of calcium nephrolithiasis, a condition where calcium stones form in the kidneys.

methyclothiazide

No data available for drug.

DRUG INTERACTION

methyclothiazide

&

methyclothiazide +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

methyclothiazide

No data available for drug.

DRUG INTERACTION

methyclothiazide

&

methyclothiazide +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

methyclothiazide

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology

Adminstartion

Patient Information Leaflet

CONTACT INFORMATION

ADDRESS

JOIN THE FASTEST GROWING HEALTHCARE COMMUNITY!

Download our APP

CONTACT INFORMATION

ADDRESS

Taking the Pain out of Your Career

DOWNLOAD APP