A Milestone Moment: FDA Approves Addyi® for Hypoactive Sexual Desire Disorder in Postmenopausal Women
December 17, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Pyrukynd
Synonyms :
mitapivat
Class :
Pyruvate Kinase-R Activators
Brand Name :
Pyrukynd
Synonyms :
mitapivat
Class :
Pyruvate Kinase-R Activators
Dosage forms & Strengths:
Adult:
Tablet
5 mg
20 mg
50 mg
Safety and efficacy are not seen in pediatrics
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 Inhibitors
CYP3A strong enhancers of the small intestine may reduce the bioavailability of mitapivat
it may enhance the metabolism when combined with zuclopenthixol
It may enhance the metabolism when combined with dexamethasone
when both drugs are combined, there may be an increased metabolism of etoposide
when both drugs are combined, there may be an increased metabolism of vinblastine
when both drugs are combined, there may be a reduced excretion rate of topotecan and result in an elevated level of serum concentration
when both drugs are combined, there may be a decrease in the serum concentration of ugt1a1 substrates
it increases the concentration of P-Glycoprotein or ABCB1 substrates in serum
may diminish the serum concentration of UGT1A1 Substrates
may diminish the serum concentration of UGT1A1 Substrates
>10%:
Back pain
Decreased estrone in males
1-10%:
Arthralgia
Hypertriglyceridemia
Gastroenteritis
Hot flush
Oropharyngeal pain
Arrhythmia
Breast discomfort
Dry mouth
Paresthesia
Mitapivat is contraindicated in patients hypersensitive to the active ingredient.
Pregnancy consideration:
Insufficient data is available regarding the use of the drug in pregnant females.
Breastfeeding warnings:
No data is available regarding the excretion of the drug in breast milk.
Pregnancy category:
Patient information leaflet
Generic Name: mitapivat
Pronounced: mit-a-piv-at
Why do we use mitapivat?
Mitapivat belongs to pyruvate kinase-R activators. It is used to treat hemolytic anemia.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
