Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Pyrukynd
Synonyms :
mitapivat
Class :
Pyruvate Kinase-R Activators
Brand Name :
Pyrukynd
Synonyms :
mitapivat
Class :
Pyruvate Kinase-R Activators
Dosage forms & Strengths:Â
Adult:Â
TabletÂ
5 mgÂ
20 mgÂ
50 mgÂ
Safety and efficacy are not seen in pediatricsÂ
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may diminish the serum concentration of CYP3A4 Inducers
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
mitapivat: they may enhance the serum concentration of CYP3A Inhibitors
may enhance the serum concentration of CYP3A4 inhibitors
may enhance the serum concentration of CYP3A4 Inhibitors
CYP3A strong enhancers of the small intestine may reduce the bioavailability of mitapivat 
it may enhance the metabolism when combined with zuclopenthixol
It may enhance the metabolism when combined with dexamethasone
when both drugs are combined, there may be an increased metabolism of etoposide   
when both drugs are combined, there may be an increased metabolism of vinblastine  
when both drugs are combined, there may be a reduced excretion rate of topotecan and result in an elevated level of serum concentration  
when both drugs are combined, there may be a decrease in the serum concentration of ugt1a1 substrates 
it increases the concentration of P-Glycoprotein or ABCB1 substrates in serum
may diminish the serum concentration of UGT1A1 Substrates
may diminish the serum concentration of UGT1A1 Substrates
>10%:Â
Back pain Â
Decreased estrone in malesÂ
1-10%:Â
Arthralgia Â
Hypertriglyceridemia Â
Gastroenteritis Â
Hot flush Â
Oropharyngeal pain Â
Hypertension Â
Arrhythmia Â
Breast discomfort Â
Constipation Â
Dry mouth Â
ParesthesiaÂ
Mitapivat is contraindicated in patients hypersensitive to the active ingredient.Â
Pregnancy consideration:Â Â
Insufficient data is available regarding the use of the drug in pregnant females.Â
Breastfeeding warnings:Â Â
No data is available regarding the excretion of the drug in breast milk.Â
Pregnancy category:Â
Patient information leafletÂ
Generic Name: mitapivatÂ
Pronounced: mit-a-piv-atÂ
Why do we use mitapivat?Â
Mitapivat belongs to pyruvate kinase-R activators. It is used to treat hemolytic anemia.  Â
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
