Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
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Brand Name :
Xenical, Alli
Synonyms :
Orlipastat, Tetrahydrolipstatin, Orlipastatum
Class :
Gastrointestinal Agents, anti-obesity agents
Brand Name :
Xenical, Alli
Synonyms :
Orlipastat, Tetrahydrolipstatin, Orlipastatum
Class :
Gastrointestinal Agents, anti-obesity agents
Dosage Forms & Strengths Â
Capsule Â
60mg-Alli Â
120mg-Xenical Â
120 mg every 8 hours daily
Dosage Forms & Strengths Â
Capsule Â
60mg-Alli Â
120mg-Xenical Â
Age: 12 above 120mg every 8 hours daily
Refer adult dosing
may diminish the absorption when combined with vitamins (fat soluble)
may diminish the absorption when combined with vitamins (fat soluble)
may diminish the absorption when combined with vitamins (fat soluble)
may diminish the absorption when combined with vitamins (fat soluble)
may diminish the absorption when combined with vitamins (fat soluble)
may diminish the vitamin absorption
May increase the anti-coagulant action when combined
it decreases the concentration of antiseizure agents in the serum
it decreases the concentration of antiseizure agents in the serum
it decreases the concentration of antiseizure agents in the serum
it decreases the concentration of antiseizure agents in the serum
it decreases the concentration of antiseizure agents in the serum
it decreases the concentration of antiretroviral agent in the serum
it decreases the concentration of antiretroviral agent in the serum
it decreases the concentration of antiretroviral agent in the serum
it decreases the concentration of antiretroviral agent in the serum
It may diminish the effects when combined with vitamin D
May reduce the plasma concentration of antiretroviral agents
it decreases the concentration of anti-seizure agents in serum
it decreases the concentration of anti-seizure agents in serum
bismuth subcitrate, metronidazole and tetracycline
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
it may diminish the excretion rate when combined with tetracyclines, resulting in an enhanced serum level
It may enhance the risk of adverse effects when combined with Haemopoetic agents
It may enhance the risk of adverse effects when combined with Haemopoetic agents
It may enhance the risk of adverse effects when combined with Haemopoetic agents
It may enhance the risk of adverse effects when combined with Haemopoetic agents
It may enhance the risk of adverse effects when combined with Haemopoetic agents
It may enhance the risk of adverse effects when combined with Lipase inhibitors
May enhances the effects of the other by pharmacodynamic synergism
Action and spectrum:Â
By reducing the amount of fat absorbed orlistat inhibits both pancreatic and gastric lipases irreversibly. This prevents the breakdown of triglycerides in the gut lumen. A mean percentage weight decrease of 5.63% was shown along with reductions in waist circumference, BMI, and absolute weight.Â
Extensive research is required to evaluate, particularly when combined with lifestyle modifications the study recommends orlistat as a possible therapy for obese teenagers.Â
Black Box Warning:Â
It is not advised for overweight, have digestive issues, gallbladder issues, and pregnant individuals. A complete therapy program that also addresses weight control, exercise, and food. Orlistat adverse effects in the stomach or intestines might be more likely when taken with high-fat meals.Â
Contraindication/Caution:Â
Chronic malabsorption syndrome, cholestasis, pregnancy, and hypersensitivity.Â
The possibility of severe liver disease, monitoring renal function, and ruling out organic reasons of obesity are among the warnings. Recommended supplements of multivitamin daily and avoid high-fat meals.Â
Pregnancy Warnings:Â
Pregnancy category:Â
AU TGA pregnancy category: B1
US FDA pregnancy category: X
Lactation:Â
Excretion of the drug in human breast milk is unknown
Pregnancy Categories:Â
Category A:Â Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N:Â There is no data available for the drug under this category.
Pharmacology:Â
Weight loss and obesity control are addressed with orlistat. It lowers the chance of weight gain.Â
Pharmacodynamics:Â
Orlistat inhibits lipase enzymes that involves in fat metabolism. It functions covalently attaching itself to the serine residues on the pancreatic and stomach lipase active sites. It slows down the triglyceride hydrolysis when taken with fat-containing foods.Â
Pharmacokinetics:Â
Absorption:Â
Orlistat has low systemic absorption, plasma radioactivity peaked, and patient plasma tests occasionally showed undetectable drug.Â
Distribution:Â
Obtaining the volume of distribution of orlistat is challenging due to its low absorption.Â
Metabolism:Â
M1 and M3, two metabolites produced when orlistat hydrolyzes in the intestinal wall. These metabolites in obese people account 42% of plasma radioactivity.Â
Excretion:Â
It is mostly excreted in the feces and fully eliminated in 3–5 days after a single oral dosage.Â
Administration:Â
For optimal effectiveness, orlistat is orally administered with each meal containing fat or within one hour after the meal. The distribution of daily fat, carbohydrate, and protein should be evenly spread across three main meals. In instances of occasional missed meals or those lacking fat content, it is recommended to skip the corresponding orlistat dose.Â
Patient Information LeafletÂ
Generic Name: orlistatÂ
Why do we use orlistat?Â
Orlistat treats one serious health issue that is spreading over the globe is obesity. Some people leading sedentary life style and neglect exercise ate more prone to obese. It is a lipase inhibitor that received approval by the FDA that is used to treat obesity.Â
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