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November 22, 2025
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Brand Name :
No Data Available.
Synonyms :
oxacillin
Class :
Pencillase resistant pencillin
Brand Name :
No Data Available.
Synonyms :
oxacillin
Class :
Pencillase resistant pencillin
Dosage forms and strengths:
Powder for injectionÂ
Infusion solutionÂ
Mild/Moderate: FDA recommends a dose of 250-500 mg given through IV or IM every 4-6hrs
Severe: FDA recommends a dose of 1 g given through IV or IM every 4-6 hrs
AHA recommends for native valve infective endocarditis (NVE) a dose of 2g given IV every 4hrs or 3g given IV for every 6hrs
AHA recommends for prosthetic valve endocarditis (PVE) a dose of 2g given IV every 4hrs
The total dose is 12g per day
Duration of treatment
Complicated NVE: 6 weeks
Non-complicated NVE: 2 weeks
For PVE: 6 weeks
IDSA Recommends a dose of 9-12 g per day IV is divided in every 4hrs
IDSA Recommends a dose of 1.5-2 g per day IV every 4 to 6hrs. The duration of treatment will be 6 weeks
IDSA Recommends for incisional surgical site infections a dose of 2 g per day IV every 6 hrs
IDSA Recommends for Skin/soft tissue infection and necrotizing infections a dose 1-2g per day IV in every 4hrs
Dosage forms and strengths:
Powder for injectionÂ
Infusion solutionÂ
For premature and neonates, a dose of 25 mg per kg per day IV or IM is recommended
For infants and children, the weight bearing less than 40 kg for mild/moderate infections a dose of 12.5 mg per kg per day given IV or IM for every 6hrs
recommended and for severe 100 mg per kg per day IV or IM given for every 4-6hrs
For infants and children, the weight bearing more than 40 kg for mild/moderate infections a dose of 250-500 mg per day given IV or IM for every 4-6hrs recommended and for severe 1 g per day IV or IM given for every 4-6hrs is recommended
AHA Recommends for 1 year and above a dose of 200 mg per kg per day given IV divided for every 4-6hrs
IDSA Recommends for Neonates of 0-7 days a dose of 75 mg per kg per day given IV divided into every 8-12hrs
Neonates of 8-28 days (about 4 weeks) 150-200 mg per kg per day given IV divided in every 6-8hrs
Infants and children, a dose of 200 mg per kg per day given IV divided in every 6hrs
The maximum dose per day is 12 g
Pediatric Infectious Diseases Society and IDSA Recommends for infants and children above 3 months a dose of 150-200 mg per kg per day given IV or IM divided in every 6-8hrs
The maximum dose per day is 12 g
IDSA Recommends children with age of 1 month and above for necrotizing infections a dose of 50 mg per kg per day IV divided in every 6hrs and for skin/soft tissue infection a dose of 100-150 mg per kg per day given IV in 4 equal divided doses
when oxacillin is combined with cholera vaccine, the oxacillin decreases the activity of the vaccine.
When oxacillin is combined with doxycycline, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with omadacycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with sarecycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with tetracycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with typhoid vaccine the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with salsalate it will increase degrees of the alternative by plasma protein binding competition
When oxacillin is combined with BCG, the oxacillin decreases the anti-tumor activity of the BCG vaccine in the bladder by pharmacodynamic antagonism.
metronidazole/tetracycline/bismuth subsalicylateÂ
the levels of oxacillin can be reduced by tetracyclines by way of pharmacodynamic antagonism
When oxacillin is combined with aspirin it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with aspirin rectal it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
Aspirin or citric acid or sodium bicarbonate
When oxacillin is combined with Aspirin or citric acid or sodium bicarbonate it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with chloramphenicol, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
Choline magnesium trisalicylate
When oxacillin is combined with choline magnesium trisalicylate it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with Ibuprofen IV it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with rose hips it will increase degrees of the alternative by decreasing the renal clearance.
When oxacillin is combined with salicylates it will increase degrees of the alternative by plasma protein binding competition.
When oxacillin is combined with willow bark it will increase degrees of the alternative by decreasing the renal clearance.
bismuth subcitrate, metronidazole and tetracycline
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may diminish the concentration of serum when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
Co-administration of oxacillin and willow bark may lead to increased levels of both drugs by affecting renal clearance
bismuth subcitrate, metronidazole and tetracycline
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
bismuth subcitrate, metronidazole and tetracycline
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
Could potentially reduce concentration serum for the active metabolite(s) of mycophenolate
When oxacillin is combined with azithromycin, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with clarithromycin, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with colestipol, the oxacillin decreases the activity of the drug by inhibition of GI absorption.
When oxacillin is combined with erythromycin base, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin ethyl succinate, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin stearate, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin base, the rifampin decreases the activity of the drug by altering metabolism.
Actions and Spectrum:Â
Actions:Â
Oxacillin is a type of antibiotic known as a beÂta-lactam. It prevents bacteria from building theÂir cell walls properly. Oxacillin attaches to proteÂins called penicillin-binding proteins, or PBPs, found in bacteÂrial cell walls. This stops the PBPs from working correctly. The bacteria can’t finish making their cell walls without theÂse proteins. Their ceÂll walls become weak and may breÂak open. Enzymes in the bacteÂria’s own walls, called autolysins, can cause this breakage and cell death. Oxacillin’s ability to disrupt cell wall formation leÂads to bacterial destruction.Â
Spectrum:Â
Oxacillin is a medicine used for treating many illnesseÂs. It can help with blood infections, brain infections, heÂart infections, bone infections, lung infeÂctions, and skin infections. Oxacillin also treats infections in artificial joints and soft tissueÂs. In some cases, it manages meÂningitis and osteomyelitis, endocarditis and discitis, pneÂumonia, skin conditions, prosthetic joint infections, and soft tissue conditions.Â
Adverse drug reactions:Â
Frequency definedÂ
0-5%Â
ArthralgiaÂ
MyalgiaÂ
FeverÂ
RashÂ
PruritusÂ
NeutropeniaÂ
Serum sicknessÂ
0-1%Â
Interstitial nephritisÂ
Stevens-Johnson syndromeÂ
exfoliative dermatitisÂ
Toxic epidermal necrolysisÂ
AgranulocytosisÂ
SeizuresÂ
Renal tubular necrosisÂ
0-0.1%Â
HypotensionÂ
Anaphylactic shockÂ
LaryngospasmÂ
laryngeal edemaÂ
Angioedema Â
Bronchospasm Â
Anaphylactoid reactionsÂ
1-10%Â
HepatitisÂ
Elevated hepatic enzymesÂ
2-5%Â
Abdominal painÂ
VomitingÂ
NauseaÂ
DiarrheaÂ
StomatitisÂ
Tongue discolorationÂ
Frequency not definedÂ
pseudomembranous colitis Â
PhlebitisÂ
Hematuria
C. difficile-associated diarrhea
Eosinophilia
ProteinuriaÂ
UrticariaÂ
Injection site reactionÂ
Black Box Warning:Â
People allergic to cephalosporin or penicillin antibiotics shouldn’t take OXACILLIN. Newborn babies with seizureÂs, yellowing skin/eyes, or a feÂver illness with sore throat also neÂed to avoid it.Â
Contraindications:Â
Cautions:Â
Pregnancy:Â
Lactation:Â
Pharmacology:Â
Oxacillin makes it hard for bacteÂria to finish building their cell walls. It attaches to speÂcial proteins (PBPs) inside the ceÂll wall. This causes the cells to breÂak down. Enzymes called autolysins help with this breÂakdown. Oxacillin may block something that stops autolysins from working.Â
Pharmacodynamics:Â
OXACILLIN is an antibiotic used to treÂat bacterial infections. It functions by preveÂnting bacteria from building a necessary moleÂcule they neeÂd to survive. This leads to the deÂath of bacterial cells. OXACILLIN combats infections like pneumonia, ear infections, skin infeÂctions, and throat infections. It works quite fast. You may start feeÂling better only a few hours afteÂr taking OXACILLIN.Â
Pharmacokinetics:Â
AbsorptionÂ
The drug geÂts absorbed quickly, reaching its top effeÂct within half an hour to one hour.Â
DistributionÂ
It spreads through the body, attaching tightly to proteÂins at 94%.Â
MetabolismÂ
The liver breaks down most of the drug.Â
Elimination and ExcretionÂ
This medicine leaveÂs your system fast – adults get rid of half in 23 to 60 minutes, kids in 0.9 to 1.8 hours. It comeÂs out through feces and urine.Â
Administration:Â
Administration is via IM or IV.Â
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Patient Information Leaflet:Â
Oxacillin is a penicillin-type antibiotic that stops bacteria from growing. It’s given through an IV   eveÂry 4 to 6 hours. Before using it, tell your doctor about any alleÂrgies you have to this medicine or other drugs. Some possible side effects are pain, sweÂlling, or peeling at the IV siteÂ. Your urine color might change. You could get muscle cramps, an irregular heartbeat, seÂizures, or signs of infection. Let your doctor know right away if side effects get worse or if you have a severe reaction. Take the  eÂxact dose your doctor prescribed. Don’t stop taking it or change the dose without talking to your doctor first. If you miss a dose, ask your doctor wheÂn to take the next oneÂ. Don’t double doses. KeeÂp oxacillin stored properly, away from pets and kids. Ask your pharmacist how to store it correctly.Â
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