Gepotidacin Gains FDA Priority Review for Breakthrough Oral Gonorrhea Therapy
December 13, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Bactocill
(United States) [Available]Synonyms :
oxacillin
Class :
Pencillase resistant pencillin
Brand Name :
Bactocill
(United States) [Available]Synonyms :
oxacillin
Class :
Pencillase resistant pencillin
Dosage forms and strengths:
Powder for injection
Infusion solution
Mild/Moderate: FDA recommends a dose of 250-500 mg given through IV or IM every 4-6hrs
Severe: FDA recommends a dose of 1 g given through IV or IM every 4-6 hrs
AHA recommends for native valve infective endocarditis (NVE) a dose of 2g given IV every 4hrs or 3g given IV for every 6hrs
AHA recommends for prosthetic valve endocarditis (PVE) a dose of 2g given IV every 4hrs
The total dose is 12g per day
Duration of treatment
Complicated NVE: 6 weeks
Non-complicated NVE: 2 weeks
For PVE: 6 weeks
IDSA Recommends a dose of 9-12 g per day IV is divided in every 4hrs
IDSA Recommends a dose of 1.5-2 g per day IV every 4 to 6hrs. The duration of treatment will be 6 weeks
IDSA Recommends for incisional surgical site infections a dose of 2 g per day IV every 6 hrs
IDSA Recommends for Skin/soft tissue infection and necrotizing infections a dose 1-2g per day IV in every 4hrs
Dosage forms and strengths:
Powder for injection
Infusion solution
For premature and neonates, a dose of 25 mg per kg per day IV or IM is recommended
For infants and children, the weight bearing less than 40 kg for mild/moderate infections a dose of 12.5 mg per kg per day given IV or IM for every 6hrs
recommended and for severe 100 mg per kg per day IV or IM given for every 4-6hrs
For infants and children, the weight bearing more than 40 kg for mild/moderate infections a dose of 250-500 mg per day given IV or IM for every 4-6hrs recommended and for severe 1 g per day IV or IM given for every 4-6hrs is recommended
AHA Recommends for 1 year and above a dose of 200 mg per kg per day given IV divided for every 4-6hrs
IDSA Recommends for Neonates of 0-7 days a dose of 75 mg per kg per day given IV divided into every 8-12hrs
Neonates of 8-28 days (about 4 weeks) 150-200 mg per kg per day given IV divided in every 6-8hrs
Infants and children, a dose of 200 mg per kg per day given IV divided in every 6hrs
The maximum dose per day is 12 g
Pediatric Infectious Diseases Society and IDSA Recommends for infants and children above 3 months a dose of 150-200 mg per kg per day given IV or IM divided in every 6-8hrs
The maximum dose per day is 12 g
IDSA Recommends children with age of 1 month and above for necrotizing infections a dose of 50 mg per kg per day IV divided in every 6hrs and for skin/soft tissue infection a dose of 100-150 mg per kg per day given IV in 4 equal divided doses
when oxacillin is combined with cholera vaccine, the oxacillin decreases the activity of the vaccine.
When oxacillin is combined with doxycycline, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with omadacycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with sarecycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with tetracycline the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with typhoid vaccine the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with salsalate it will increase degrees of the alternative by plasma protein binding competition
When oxacillin is combined with BCG, the oxacillin decreases the anti-tumor activity of the BCG vaccine in the bladder by pharmacodynamic antagonism.
metronidazole/tetracycline/bismuth subsalicylate
the levels of oxacillin can be reduced by tetracyclines by way of pharmacodynamic antagonism
When oxacillin is combined with aspirin it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with aspirin rectal it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
Aspirin or citric acid or sodium bicarbonate
When oxacillin is combined with Aspirin or citric acid or sodium bicarbonate it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with chloramphenicol, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
Choline magnesium trisalicylate
When oxacillin is combined with choline magnesium trisalicylate it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with Ibuprofen IV it will increase degrees of the alternative by plasma protein binding competition or by decreasing the renal clearance.
When oxacillin is combined with rose hips it will increase degrees of the alternative by decreasing the renal clearance.
When oxacillin is combined with salicylates it will increase degrees of the alternative by plasma protein binding competition.
When oxacillin is combined with willow bark it will increase degrees of the alternative by decreasing the renal clearance.
bismuth subcitrate, metronidazole and tetracycline
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
The interaction may depress the therapeutic efficacy of tetracyclines
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may increase the anticoagulant effect
may diminish the concentration of serum when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
may diminish the concentration of serum when combined with aminoglycosides
Co-administration of oxacillin and willow bark may lead to increased levels of both drugs by affecting renal clearance
bismuth subcitrate, metronidazole and tetracycline
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
tetracyclines may diminish the therapeutic effect of penicillins
bismuth subcitrate, metronidazole and tetracycline
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
may reduce the therapeutic effect of penicillins
Could potentially reduce concentration serum for the active metabolite(s) of mycophenolate
When oxacillin is combined with azithromycin, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with clarithromycin, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with colestipol, the oxacillin decreases the activity of the drug by inhibition of GI absorption.
When oxacillin is combined with erythromycin base, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin ethyl succinate, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin stearate, the oxacillin decreases the activity of the drug by pharmacodynamic antagonism.
When oxacillin is combined with erythromycin base, the rifampin decreases the activity of the drug by altering metabolism.
Actions and Spectrum:
Actions:
Oxacillin is a type of antibiotic known as a beta-lactam. It prevents bacteria from building their cell walls properly. Oxacillin attaches to proteins called penicillin-binding proteins, or PBPs, found in bacterial cell walls. This stops the PBPs from working correctly. The bacteria can’t finish making their cell walls without these proteins. Their cell walls become weak and may break open. Enzymes in the bacteria’s own walls, called autolysins, can cause this breakage and cell death. Oxacillin’s ability to disrupt cell wall formation leads to bacterial destruction.
Spectrum:
Oxacillin is a medicine used for treating many illnesses. It can help with blood infections, brain infections, heart infections, bone infections, lung infections, and skin infections. Oxacillin also treats infections in artificial joints and soft tissues. In some cases, it manages meningitis and osteomyelitis, endocarditis and discitis, pneumonia, skin conditions, prosthetic joint infections, and soft tissue conditions.
Adverse drug reactions:
Frequency defined
0-5%
Arthralgia
Myalgia
Fever
Rash
Pruritus
Neutropenia
Serum sickness
0-1%
Interstitial nephritis
Stevens-Johnson syndrome
exfoliative dermatitis
Toxic epidermal necrolysis
Agranulocytosis
Seizures
Renal tubular necrosis
0-0.1%
Hypotension
Anaphylactic shock
Laryngospasm
laryngeal edema
Angioedema
Bronchospasm
Anaphylactoid reactions
1-10%
Hepatitis
Elevated hepatic enzymes
2-5%
Abdominal pain
Vomiting
Nausea
Diarrhea
Stomatitis
Tongue discoloration
Frequency not defined
pseudomembranous colitis
Phlebitis
Hematuria
C. difficile-associated diarrhea
Eosinophilia
Proteinuria
Urticaria
Injection site reaction
Black Box Warning:
People allergic to cephalosporin or penicillin antibiotics shouldn’t take OXACILLIN. Newborn babies with seizures, yellowing skin/eyes, or a fever illness with sore throat also need to avoid it.
Contraindications:
Cautions:
Pregnancy:
Lactation:
Pharmacology:
Oxacillin makes it hard for bacteria to finish building their cell walls. It attaches to special proteins (PBPs) inside the cell wall. This causes the cells to break down. Enzymes called autolysins help with this breakdown. Oxacillin may block something that stops autolysins from working.
Pharmacodynamics:
OXACILLIN is an antibiotic used to treat bacterial infections. It functions by preventing bacteria from building a necessary molecule they need to survive. This leads to the death of bacterial cells. OXACILLIN combats infections like pneumonia, ear infections, skin infections, and throat infections. It works quite fast. You may start feeling better only a few hours after taking OXACILLIN.
Pharmacokinetics:
Absorption
The drug gets absorbed quickly, reaching its top effect within half an hour to one hour.
Distribution
It spreads through the body, attaching tightly to proteins at 94%.
Metabolism
The liver breaks down most of the drug.
Elimination and Excretion
This medicine leaves your system fast – adults get rid of half in 23 to 60 minutes, kids in 0.9 to 1.8 hours. It comes out through feces and urine.
Administration:
Administration is via IM or IV.
Patient Information Leaflet:
Oxacillin is a penicillin-type antibiotic that stops bacteria from growing. It’s given through an IV every 4 to 6 hours. Before using it, tell your doctor about any allergies you have to this medicine or other drugs. Some possible side effects are pain, swelling, or peeling at the IV site. Your urine color might change. You could get muscle cramps, an irregular heartbeat, seizures, or signs of infection. Let your doctor know right away if side effects get worse or if you have a severe reaction. Take the exact dose your doctor prescribed. Don’t stop taking it or change the dose without talking to your doctor first. If you miss a dose, ask your doctor when to take the next one. Don’t double doses. Keep oxacillin stored properly, away from pets and kids. Ask your pharmacist how to store it correctly.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
