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Brand Name :
Choledyl SA
(United States) [DSC]Synonyms :
oxtriphylline
Class :
Methylxanthines
Brand Name :
Choledyl SA
(United States) [DSC]Synonyms :
oxtriphylline
Class :
Methylxanthines
Dosage Forms & Strengths
Tablet
200 mg
400 mg
600 mg
Take a maintenance dose orally of 4.7 mg/kg in each 8 hours
Dosage Forms & Strengths
Tablet
200 mg
400 mg
600 mg
for 1 to 9 years old:
Take a maintenance dose orally of 6.2 mg/kg in each 6 hours
for 9 to 16 years old:
Take a maintenance dose orally of 4.7 mg/kg in each 6 hours
Refer to adult dosing
amobarbital: it may decreased the serum concentration of oxtriphylline
amphetamine: it may increase the risk of adverse effects of oxtriphylline
anagrelide: it may decrease the metabolism of oxtriphylline
anakinra: it may increase the metabolism of oxtriphylline
antipyrine: it may decrease the metabolism of oxtriphylline
arformoterol: it may increase the risk of hypokalemia with oxtriphylline
binimetinib: it may decrease the metabolism of oxtriphylline
bisoprolol: it may increase the risk of adverse effects of oxtriphylline
bortezomib: it may decrease the metabolism of oxtriphylline
brexanolone: it may increase the excretion rate of oxtriphylline
brivaracetam: it may increase the excretion rate of oxtriphylline
bromazepam: it may decrease the therapeutic efficacy of oxtriphylline
carvedilol: it may increase the risk of adverse effects of oxtriphylline
celiprolol: it may increase the risk of adverse effects of oxtriphylline
Cenobamate: it may increase the excretion rate of oxtriphylline
chlordiazepoxide: it may decrease the therapeutic efficacy of oxtriphylline
chlorpromazine: it may decrease the metabolism of oxtriphylline
Actions and Spectrum
oxtriphylline works primarily by inhibiting the enzyme phosphodiesterase (PDE). This leads to an increase in cyclic adenosine monophosphate (cAMP) levels within cells. The elevated cAMP levels result in relaxation of smooth muscles in the airways, leading to bronchodilation.
Frequency not defined
Seizures
Irregular heartbeat
Difficulty in breathing
Nausea or vomiting
Throat irritation
Swelling of lips, tongue, face, or hives
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
oxtriphylline’s pharmacological effect is the relaxation of smooth muscles in the bronchial airways.
This leads to widening of the airways, improved airflow, and relief from symptoms such as wheezing and shortness of breath.
Pharmacodynamics
The relaxation of smooth muscles in the bronchial airways leads to bronchodilation.
This effect is effective in relieving the symptoms of airway constriction seen in conditions like asthma and COPD.
Pharmacokinetics
Absorption
oxtriphylline is absorbed in the gastrointestinal tract.
Distribution
oxtriphylline is distributed throughout the body via the bloodstream.
Metabolism
oxtriphylline undergoes metabolism in the liver through enzymatic processes by cytochrome P450 enzymes.
Elimination and excretion
oxtriphylline and its metabolites are excreted through the kidneys.
Administration
oxtriphylline is administered orally in the form of tablets and capsules.
Patient information leaflet
Generic Name: oxtriphylline
Why do we use oxtriphylline?
oxtriphylline is used in treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).
oxtriphylline is a bronchodilator used for the treatment of emphysema.
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