Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
Pitocin
(United States) [Available]Synonyms :
oxytocin
Class :
Uterine stimulants; Oxytocin agents
Brand Name :
Pitocin
(United States) [Available]Synonyms :
oxytocin
Class :
Uterine stimulants; Oxytocin agents
Dosage Forms & Strengths
Injectable solution
10 units/ml
Not recommended for pediatrics
Not required
oxytocin: they may increase the QTc-prolonging effect of QTc-prolonging Agents
oxytocin: they may increase the QTc-prolonging effect of QTc-prolonging Agents
oxytocin: they may increase the QTc-prolonging effect of QTc-prolonging Agents
oxytocin: they may increase the QTc-prolonging effect of QTc-prolonging Agents
may enhance the Qtc prolonging effect
may enhance the Qtc prolonging effect
may enhance the Qtc prolonging effect
may enhance the Qtc prolonging effect
may enhance the Qtc prolonging effect
It may enhance the risk of adverse effects when combined with Cephalosporins
It may enhance the risk of adverse effects when combined with Cephalosporins
It may enhance the risk of adverse effects when combined with Cephalosporins
It may enhance the risk of adverse effects when combined with Cephalosporins
It may enhance the risk of adverse effects when combined with Cephalosporins
fexinidazole may enhance the QTc-prolonging effect of QT-prolonging Agents
may increase the effect of each other through pharmacodynamic synergism
the risk of hypertension may be increased
Actions and Spectrum
Oxytocin acts by binding some oxytocin receptors represented by the guanine nucleotide binding protein coupled receptors (GPCRs) that are present in the brain, the mammary glands and the uterus, along with other organs. The physiological effects of oxytocin originate from a chain of intracellular signaling which are caused upon association with their receptors.
Frequency not Defined
Black Box Warning
oxytocin is not indicated in elective labor induction.
Contraindication/Caution:
Pregnancy/Lactation
Pregnancy consideration:
Category X
Breastfeeding warnings:
Lactating mothers should not breastfeed during the therapy
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
The oxytocin hormone generates its maximum effects specifically in the brain, mammary glands, and the uterus by binding with the oxytocin receptor. It achieves this by increasing calcium ion levels to stimulate contraction of the uterus that leads to delivery. In addition to this, it has the property of inducing the myoepithelial cells in the mammary glands to contract, increasing lactation or release of the milk.
Pharmacodynamics:
The pharmacodynamics of oxytocin is related to the mode through which this hormone produces its effect (s) on the body. oxytocin binds and activates receptors called oxytocin receptors (OXTR) which are located on the surface of target cells. The results of oxytocin in the tissues and organ systems vary with the type and distribution of oxytocin receptors, as well as the signaling pathways which follow the activation of the receptors.
Pharmacokinetics:
Absorption
Duration of action is 2 to 3 hours for intramuscular and an hour for intravenous
Distribution
The volume of distribution is 0.3 L/kg
Metabolism
The drug is rapidly metabolized in plasma & liver
Elimination and Excretion
The drug is excreted in urine
The half-life is achieved in1-6 min; it may decrease in late pregnancy & during lactation
Administration
oxytocin is usually given intravenously or intramuscularly
Patient information leaflet
Generic Name: oxytocin
Pronounced: OX-i-TOE-sin
Why do we use oxytocin?
Oxytocin hormones are responsible for starting labor which increases uterine contraction and manages postpartum bleeding. It is also used to help the women who undergo an incomplete miscarriage to stimulate uterine contractions.
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