Long COVID Patterns in the RECOVER-Adult Study
November 21, 2025
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Brand Name :
zemplar
Synonyms :
paricalcitol
Class :
Vitamin D derivatives
Dosage Forms & StrengthsÂ
CapsuleÂ
1mcg,2mcg,4mcgÂ
Injectable solutionÂ
2mcg/mlÂ
5mcg/mlÂ
Secondary HyperparathyroidismÂ
Indicated for Chronic kidney disease stage 3 and 4:
Initial dose:
PTH>500 pg/ml: 2 mcg orally every day or four mcg orally three times/week
PTH<500 pg/ml: 1 mcg orally every day or two mcg orally three times/week
Chronic kidney disease stage 5
Initial dose:
0.04-0.1 mcg/kg Intravenous weekly three times
Increase up to 2-4mcg every 2-4 weeks
Dosage Forms & StrengthsÂ
CapsuleÂ
1mcg,2mcg,4mcgÂ
Injectable solutionÂ
2mcg/mlÂ
5mcg/mlÂ
Secondary HyperparathyroidismÂ
Indicated for Chronic kidney disease stage 3 and 4
:
Oral dosing
<10 years: Safety and efficacy not established
10-16 years: 1mcg orally, weekly, three times every four weeks. Increase dose up to 1mcg every four weeks
Chronic kidney disease stage 5
Oral dosing
<10 years: Safety and efficacy not established
10-16 years: 1mcg orally, weekly, three times every four weeks. Increase dose up to 1mcg every four weeks
Intravenous dosing
<5 years: Safety and efficacy not established
>5 years:
PTH>500 pg/ml:0.08mcg/kg 3times a week intravenously
PTH<500 pg/ml: 0.04mcg/kg 3times a week intravenously
may enhance the serum concentration of vitamin D analogs
may decrease the serum concentration of vitamin D analogs
may decrease the therapeutic effect
may diminish the vitamin absorption
may enhance the serum concentration of vitamin D analogs
They may diminish the serum concentration when combined with bile acid sequestrants
it may decrease the serum concentration of Vitamin D Analogs
may decrease the level of serum concentration of vitamin D analogs
aluminum hydroxide, magnesium hydroxide, and simethiconeÂ
may enhance the serum concentration when combined with aluminum hydroxide
may diminish the serum concentration when combined with vitamin D analogs
may enhance the serum concentration when combined with sucralfate
aluminum hydroxide/magnesium hydroxideÂ
may enhance the serum concentration of Aluminum Hydroxide
mineral oil: they may reduce the serum concentration of vitamin D analogs
mineral oil: they may diminish the serum concentration of vitamin D analog
may diminish the serum concentration when combined with vitamin D analogs
may diminish the serum concentration when combined with vitamin D analogs
may diminish the serum concentration when combined with vitamin D analogs
may diminish the serum concentration when combined with vitamin D analogs
may diminish the serum concentration when combined with vitamin D analogs
may diminish the serum concentration when combined with vitamin D analogs
may enhance the serum concentration of vitamin D analogs
may have an increased adverse effect when combined with other vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may increase the adverse effects of each other
may increase the toxic effects of vitamin D analogs
may increase the toxic effects of vitamin D analogs
may increase the toxic effects of vitamin D analogs
may increase the toxic effects of vitamin D analogs
may have an increased adverse effect when combined with burosumab
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with other vitamin D analogs
may increase the toxic effect when combined
may have an increased adverse effect when combined with vitamin D analogs
may have an increased adverse effect when combined with vitamin D analogs
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the arrhythmogenic effect of cardiac glycosides
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may enhance the serum concentration
may increase the hypercalcaemic effect
may increase the hypercalcaemic effect
may increase the hypercalcaemic effect
may increase the hypercalcaemic effect
may have an increased hypercalcemic effect when combined with Vitamin D and its analogs
may have an increased hypercalcemic effect when combined with Vitamin D and its analogs
may have an increased hypercalcemic effect when combined with Vitamin D and its analogs
may have an increased hypercalcemic effect when combined with Vitamin D and its analogs
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
calcium salts can increase the adverse and potentially toxic effects of Vitamin D Analogs
Vitamin D analogs: they may increase the antiplatelet effect of antiplatelet agents
Vitamin D analogs: they may increase the antiplatelet effect of antiplatelet agents
Vitamin D analogs: they may increase the antiplatelet effect of antiplatelet agents
Vitamin D analogs: they may increase the antiplatelet effect of antiplatelet agents
Vitamin D analogs: they may increase the antiplatelet effect of antiplatelet agents
fedratinib increases the effect of paricalcitol by altering the intestinal/ hepatic CYP3A4 enzyme metabolism fedra
calcium salts increase the toxicity of vitamin D analogs
calcium salts increase the toxicity of vitamin D analogs
calcium salts increase the toxicity of vitamin D analogs
calcium salts increase the toxicity of vitamin D analogs
calcium salts increase the toxicity of vitamin D analogs
may decrease the serum concentration of Vitamin D Analogs.
may enhance the adverse/toxic effect of Vitamin D analogs
may enhance the adverse/toxic effect of vitamin D analogs
may enhance the adverse/toxic effect of vitamin D analogs
may enhance the adverse/toxic effect of vitamin D analogs
may enhance the adverse/toxic effect of vitamin D analogs
may enhance the adverse/toxic effect of vitamin D analogs
may increase the hypercalcemic effect of thiazide and thiazide like diuretics
lisinopril/hydrochlorothiazideÂ
may increase the hypercalcaemic effect of thiazide and thiazide like diuretics
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased arrhythmogenic effect when combined with cardiac glycosides
may have an increased arrhythmogenic effect when combined with cardiac glycosides
may have an increased arrhythmogenic effect when combined with cardiac glycosides
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
spironolactone and hydrochlorothiazide
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
may have an increased hypercalcemic effect when combined with vitamin D analogs
Frequency defined:Â Â
>10%Â
NauseaÂ
1-10%Â
EdemaÂ
ChillsÂ
LightheadednessÂ
Flu-like symptomsÂ
HypokalemiaÂ
Increase in creatinine levelsÂ
VomitingÂ
PalpitationsÂ
PneumoniaÂ
GI bleedingÂ
SepsisÂ
HyperkalemiaÂ
Post-marketing reportsÂ
HeadacheÂ
Abdominal painÂ
AngioedemaÂ
HyperphosphatemiaÂ
Â
Pregnancy consideration:Â Â
US FDA Pregnancy category: CÂ
Lactation: Excretion of the drug in human breast milk is unknown Â
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Patient information leafletÂ
Generic Name: paricalcitolÂ
Pronounced: [ PAR-i-KAL-si-tol ]Â
Why do we use paricalcitol?Â
It is used to treat hyperparathyroidism linked to chronic renal disease with a stage 3 or stage 5Â
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