Gepotidacin Gains FDA Priority Review for Breakthrough Oral Gonorrhea Therapy
December 13, 2025
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Brand Name :
Pipracil
Synonyms :
piperacillin
Class :
Class: Antimicrobials and Antiviral drugs; Sub class: Penicillins
Brand Name :
Pipracil
Synonyms :
piperacillin
Class :
Class: Antimicrobials and Antiviral drugs; Sub class: Penicillins
Dosage forms and strengths:
Powder for injection
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
A dose of 3-4 g IV given every 4-6hrs is recommended
The maximum dose per day recommended is 24g
Mild/Moderate: A dose of 6-8 g per day IV or IM given every 6-12hrs is recommended
Severe: A dose of 8-16 g per day IV or IM given every 6-8hrs is recommended
Mild/moderate: A dose of 2g IM given per day once
Dosage forms and strengths:
Powder for injection
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 200-300mg/kg/day given IV in divided doses for every 4-6hrs is recommended
The total dose per day given is 18g
For children 12years and above a dose of 125-200mg/kg/day given IV in divided doses for every 6-8hrs is recommended
The total dose per day given is 16g
piperacillin will increase the effectiveness of argatroban by anticoagulation.
piperacillin decreases the effectiveness of bcg vaccine by antagonism.
piperacillin will increase the effectiveness of bivalirudin by anticoagulation.
piperacillin decreases the effectiveness of cholera vaccine by antagonism.
piperacillin will increase the effectiveness of dalteparin by anticoagulation.
piperacillin will increase the effectiveness of enoxaparin by anticoagulation
piperacillin will increase the effectiveness of heparin by anticoagulation
when both drugs are combined, there may be a reduced effect of piperacillin
piperacillin decreases the effectiveness of azithromycin by antagonism.
piperacillin decreases the effectiveness of chloramphenicol by altering intestinal flora.
piperacillin decreases the effectiveness of clarithromycin by antagonism.
piperacillin decreases the effectiveness of demeclocycline by antagonism.
piperacillin decreases the effectiveness of doxycycline by antagonism.
piperacillin decreases the effectiveness of erythromycin lactobionate by antagonism.
piperacillin decreases the effectiveness of erythromycin stearate by antagonism.
piperacillin decreases the effectiveness of minocycline by antagonism.
probenecid will increase the effect of piperacillin by acidic drug competition.
piperacillin decreases the effectiveness of tetracycline by antagonism.
piperacillin increases the toxic effects of vancomycin. The cause of the reaction is unknown.
piperacillin increases the effectiveness of vecuronium by synergism.
piperacillin increases the effectiveness of warfarin by synergism
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
penicillins may decrease the serum concentration of Aminoglycosides
When piperacillin is used together with ouabain, this leads to reduction in piperacillin excretion
penicillins may iincrease the anticoagulant effect of Vitamin K Antagonists
penicillins may decrease serum concentrations of the active metabolite(s) of mycophenolate
may have a decrease in excretion when combined with piperacillin
piperacillin increases the effectiveness of amikacin by synergism.
piperacillin increases the effectiveness of aspirin by protein binding competition.
piperacillin increases the effectiveness of aspirin rectal by protein binding competition.
aspirin citric acid sodium bicarbonate
piperacillin increases the effectiveness of aspirin/citric acid/sodium bicarbonate by protein binding competition.
chlorthiazide increases the effect of piperacillin by decreasing renal clearance.
piperacillin increases the effectiveness of gentamicin by synergism.
hydrochlorothiazide increases the effect of piperacillin by decreasing renal clearance.
piperacillin will increase the effect of ibuprofen IV by acidic drug competition.
piperacillin increases the effectiveness of neomycin by synergism.
piperacillin increases the effectiveness of streptomycin by synergism.
piperacillin increases the effectiveness of tobramycin by synergism.
piperacillin will increase the effect of willow bark by acidic drug competition.
Actions and spectrum:
Piperacillin stops the last step of making the bacterial cell wall. It attaches to specific proteins in that wall called penicillin-binding proteins (PBPs). Bacteria have enzymes that can break down their own cell walls, called autolysins. Piperacillin may block something that usually stops those autolysins from working, causing the cell to burst open.
Adverse drug reactions:
Frequency defined
1-10%
Diarrhea
Loose stools
Rash
Pruritis
Thrombophlebitis
Injection site pain
<1%
Seizure
Hemolytic anemia
Postive Coombs reaction
Prolonged prothrombin time
Interstitial nephritis
Hypersensitivity
Anaphylaxis
Thrombophlebitis
Injection site pain
Headache
Fever
Intestinal infection due to pseudomonas
Frequency not defined
Electrolyte imbalance
Elevated liver enzymes
Drowsiness
Nausea
Vomiting
Bloody diarrhea
pseudomembranous colitis
Clostridium difficile-associated diarrhea
Black Box Warning
No specific warnings are available
Contraindication/Caution:
Contraindication:
Seizures
Allergic reaction
Unexplained bleeding or bruising
Pregnancy consideration:
Lactation:
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Piperacillin fights bacteria. It works against bacteria like Pseudomonas aeruginosa. This drug belongs to the antibiotic family. Doctors commonly prescribe Piperacillin to combat infections caused by susceptible organisms.
Pharmacodynamics:
Piperacillin, an antibiotic, fights bacterial infections. It works by blocking cell wall formation in bacteria. This stops certain gram-positive bacteria from growing. Piperacillin binds to proteins involved in cell wall synthesis. It can overcome many enzymes that break down antibiotics. These include beta-lactamases, penicillinases, and extended-spectrum types. So, piperacillin remains effective against a wide range of bacteria.
Pharmacokinetics:
Absorption
Piperacillin is not absorbed well when taken by mouth.
Distribution
After injecting 50 mg/kg into the vein in newborns, it spreads through a volume of 101 ml/kg.
Metabolism
Piperacillin does not break down much.
Elimination and excretion
Mostly, it leaves the body when the kidneys filter or secrete it into urine. Most of the drug stays unchanged. It has a short-lasting effect because its half-life, the time it takes to decrease by half, is only 36 to 72 minutes.
Administration:
To be administered as suggested by the physician
Patient Information Leaflet:
Pronunciation: pi-per-i-sil-in
Use: This broad-range antibiotic fights certain infections. It treats urinary tract troubles, pneumonia from everyday life, acute bile duct inflammation, moderate and severe illnesses, simple gonorrhea cases, and pseudomonas illnesses too.
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