Don’t Ignore Your Kidneys: Early Action Can Slow CKD
January 19, 2026
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Brand Name :
Esbriet
(United States) [Available]Synonyms :
pirfenidone
Class :
Anti-inflammatory drugs and Antifibrotic agent
Brand Name :
Esbriet
(United States) [Available]Synonyms :
pirfenidone
Class :
Anti-inflammatory drugs and Antifibrotic agent
Dosage Forms & Strengths
Capsule, Oral:
267 mg
Tablet, Oral:
267 mg
801 mg
1st week:
267
mg
3 times a day
7
days
2nd week: 534 mg 3 times a day for the next 8 to 14 days
3rd week: 801 mg 3 times a day for day 15 and thereafter (do not exceed 2,403 mg/day)
pirfenidone: they may enhance the serum concentration of CYP1A2 Inhibitors
pirfenidone: they may enhance the serum concentration of CYP1A2 Inhibitors
pirfenidone: they may enhance the serum concentration of CYP1A2 Inhibitors
pirfenidone: they may enhance the serum concentration of CYP1A2 Inhibitors
pirfenidone: they may enhance the serum concentration of CYP1A2 Inhibitors
ciprofloxacin inhaled (Pending FDA approval)
may enhance the serum concentration of ciprofloxacin
may enhance the serum concentration of CYP1A2 Inhibitors
edoxaban: it may enhance the toxic effect of Anti-Inflammatory Agents
caplacizumab: it may enhance the toxic effect of Anti-Inflammatory Agents
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
may have an increased thrombogenic effect when combined with anti- coagulant inhibitor complex
it enhances by affecting the hepatic enzyme CYP1A2 metabolism
anti-inhibitor coagulant complex
may have an increased thrombogenic effect when combined with anti-inhibitor coagulant complex
Pirfenidone may increase the photosensitizing effect of verteporfin
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may decrease the therapeutic effect when combined with thrombolytic agents
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
when both drugs are combined, there may be a decrease in the therapeutic effect
tretinoin increases the effect of thrombogenesis of antifibrotic agents
Frequency defined:
>10%
Skin rash
Abdominal pain
Anorexia
Diarrhea
Vomiting
Nausea
1% to 10%
Pruritis
Skin photosensitivity
Weight loss
Insomnia
Arthralgia
Postmarketing
Angioedema
Hepatotoxicity
Pregnancy consideration: Animal studies reported with adverse reactions.
Lactation: excretion of pirfenidone in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Pirfenidone
Pronounced: pirfenidone
Why do we use pirfenidone?
Pirfenidone is used to treat idiopathic pulmonary fibrosis.
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