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November 25, 2025
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Brand Name :
Renvela, Renagel
Synonyms :
sevelamer
Class :
Phosphate binders
Brand Name :
Renvela, Renagel
Synonyms :
sevelamer
Class :
Phosphate binders
Dosage forms & StrengthsÂ
TabletÂ
800mg (Renvela,Renagel)Â
400mg (Renagel)Â
Oral suspension as powder packetÂ
2400mg (Renvela)Â
800mg (Renvela)Â
Dosage forms & StrengthsÂ
TabletÂ
800mg (Renvela)Â
Oral suspension as powder packetÂ
2400mg (Renvela)Â
800mg (Renvela)Â
Refer to adult dosing.Â
sevelamer may decrease the absorption of Quinolones
sevelamer may decrease the absorption of Quinolones
may diminish the absorption when combined with quinolones
may diminish the absorption when combined with quinolones
phosphate binders: they may diminish the serum concentration of antacids
phosphate binders: they may diminish the serum concentration of antacids
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
when both drugs are combined, there may be decrease effect of sodium phosphates
may diminish the quinolones absorption
may diminish the serum concentration of magnesium salts
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may have a decreased serum concentration when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
calcium salts: they may diminish the absorption of phosphate binders
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may diminish the serum concentration when combined with phosphate supplements
may diminish the absorption when combined with phosphate supplements
may diminish the serum concentration of magnesium salts
may decrease the serum concentration when combined
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the effects of the drug by GI absorption inhibition
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
may decrease the serum concentration
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
It may enhance the risk of adverse effects when combined with phosphate binders
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increased nephrotoxic effect when combined with NSAIDs
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increasingly adverse effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
spironolactone and hydrochlorothiazide
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
may have an increased nephrotoxic effect when combined with sodium phosphates
Actions and Spectrum:Â
sevelamer is a medication that is used to treat high levels of phosphate in the blood in patients with chronic kidney disease. It works by binding to phosphate in the diet, preventing its absorption into the body, and thus reducing the amount of phosphate that reaches the bloodstream.Â
The actions and spectrum of sevelamer include:Â
Frequency definedÂ
>10%Â
Limb pain (13%)Â
Nasopharyngitis (14%)Â
Vomiting (22%)Â
Arthralgia (12%)Â
Nausea (20%)Â
Bronchitis (11%)Â
Pruritus (13%)Â
Hypertension (10%)Â
Dyspepsia (16%)Â
Diarrhea (19%)Â
Dyspnea (10%)Â Â
1-10%Â
Constipation (8%)Â
Abdominal pain (9%)Â
Hypercalcemia (5-7%)Â
Peritonitis (during peritoneal dialysis: 8%)Â
Flatulence (8%)Â
Frequency not definedÂ
PruritusÂ
Upper respiratory infectionÂ
Intestinal obstructionÂ
CoughÂ
HeadacheÂ
Fecal impactionÂ
RashÂ
PyrexiaÂ
Back painÂ
Intestinal perforationÂ
Â
Black Box Warning:Â
The black box warning for sevelamer is related to gastrointestinal (GI) adverse reactions, specifically ileus, bowel obstruction, and perforation. Ileus is a condition where the normal movement of the intestines is slowed or stopped, leading to abdominal pain, bloating, and constipation.
Bowel obstruction occurs like if there is a blockage in the small or large intestine, which can cause severe pain, nausea, and vomiting. Perforation is a potentially life-threatening condition of the stomach or intestine, allowing contents to leak out into the abdominal cavity.Â
The black box warning advises healthcare professionals to monitor patients taking sevelamer for signs and symptoms of these GI adverse reactions, especially if they have a history of GI disorders or surgery. Patients should also be advised to seek medical attention immediately if they experience severe abdominal pain, nausea, vomiting, or other signs of GI distress.Â
Contraindication/Caution:Â
CautionÂ
Pregnancy consideration:Â Â
AU TGA pregnancy category: B3
US FDA pregnancy category: CÂ
Lactation:  Â
Excreted into human milk is Not known. Â
Pregnancy category:Â
Pharmacology:Â
sevelamer is a medication that belongs to a class of drugs called phosphate binders. It is a non-absorbed, cross-linked polymer that binds to phosphate in the GI tract, preventing its absorption into the bloodstream.Â
Pharmacodynamics:Â
Mechanism of action: sevelamer works by binding to phosphate ions in the gut, forming an insoluble complex that is excreted in the feces. This reduces the amount of phosphate that is absorbed into the bloodstream, which helps to lower the levels of phosphate in the blood.Â
Pharmacokinetics:Â
AbsorptionÂ
sevelamer is not absorbed into the bloodstream, and so its pharmacokinetics are not well described. Studies have shown that sevelamer hydrochloride is poorly absorbed from the gastrointestinal tract, with less than 0.5% of the dose being absorbed.Â
DistributionÂ
UnknownÂ
MetabolismÂ
sevelamer is not metabolized by the liver.Â
Elimination and ExcretionÂ
excreted unchanged in the feces. The elimination half-life of sevelamer is approximately six hours.Â
Administration:Â
Oral administrationÂ
sevelamer is usually taken with meals and should be swallowed whole with plenty of water. It is key to follow the dosage instructions provided by your physician, which may vary depending on your individual needs and medical condition.Â
Patient information leafletÂ
Generic Name: sevelamerÂ
Pronounced:Â Â
Why do we use sevelamer?Â
sevelamer is a medication that is primarily used to control high levels of phosphate in the blood of people with end-stage renal disease (ESRD) who are undergoing dialysis. It is an oral phosphate binder that works by binding to dietary phosphate in the gut, preventing its absorption into the bloodstream.Â
Some of the uses of sevelamer include:Â
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