Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
Longum, Kelfizina
Synonyms :
Solfametopirazina, Sulfalene
Class :
Sulfonamide antibiotics
Brand Name :
Longum, Kelfizina
Synonyms :
Solfametopirazina, Sulfalene
Class :
Sulfonamide antibiotics
Dosage Forms & Strengths
Tablets
1 grams
2 grams
Lower Respiratory Tract Infections
It is mostly recommended for respiratory tract infections, chronic bronchitis, and urinary tract infections
The usual recommended single dose per week only once is 2 g via oral administration
Dose Adjustments
Reduction in dosage is needed depending upon the condition
It is mostly recommended for respiratory tract infections, chronic bronchitis, and urinary tract infections
The usual recommended single dose per week only once is 2 g via oral administration
Dose Adjustments
Reduction in dosage is needed depending upon the condition
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
the efficacy of acarbose can be raised when used in combination with sulfametopyrazine
the efficacy of acetohexamide can be raised when used in combination with sulfametopyrazine
the efficacy of albiglutide can be raised when used in combination with sulfametopyrazine
the efficacy of alogliptin can be raised when used in combination with sulfametopyrazine
Sulfametopyrazine may lower the benzylpenicillin excretion rate, which could result in a higher serum level
the efficacy of exenatide can be raised when used in combination with sulfametopyrazine
the efficacy of gliclazide can be raised when used in combination with sulfametopyrazine
the efficacy of glimepiride can be raised when used in combination with sulfametopyrazine
the efficacy of glipizide can be raised when used in combination with sulfametopyrazine
the efficacy of gliquidone can be raised when used in combination with sulfametopyrazine
Actions and Spectrum:
Actions:
Sulfametopyrazine functions by competing with PABA for the inhibition of dihydropteroate synthetase, a crucial enzyme involved in the biosynthesis of folic acid in bacteria.
Spectrum:
Sulfametopyrazine is a synthetic antibiotic that inhibits bacterial growth by blocking PABA in the folic acid metabolism cycle, but some bacteria can become resistant to it.
Frequency not defined
Liver necrosis
Nephritis
Myocarditis
Serum sickness like syndrome
Fibrosing alveolitis
Kernicterus in premature neonates
Nausea
Anuria
Stevens johnson syndrome
Diarrhea
Black Box Warning:
Drink enough water to reduce crystalluria risk; stop if rash appears; be cautious with severe kidney/liver issues, allergies, or asthma.
Contraindication/Caution:
Contraindications
Pregnancy (3rd trimester)
Blood disorders
Acute porphyria
SLE
Lactation
Hypersensitivity
Allergy
Infants less than 2 months
Cautions
Breastfeeding
Pregnancy
Crystalluria
Hepatic impairment
G6PD deficiency
Renal impairment
Asthma
Pregnancy/Lactation
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Sulfametopyrazine is a sulfonamide that blocks nucleic acid synthesis in susceptible organisms by inhibiting PABA conversion to dihydrofolic acid. It’s primarily bacteriostatic but can be bactericidal in low thymine environments.
Pharmacodynamics:
Sulfametopyrazine competes with PABA for binding to a bacterial enzyme, dihydropteroate synthase, blocking the production of folic acid.
Pharmacokinetics:
Absorption
Rapid absorption
Distribution
Protein-bound is 60-80%
Metabolism
5% of the drug is metabolized to acetyl derivative.
Elimination and Excretion
The half-life of the drug is 60-65 hours.
The drug is excreted in urine slowly.
Administration:
Sulfametopyrazine tablets are taken with water, suspension needs shaking and measured dose, and it’s important to complete the treatment even if symptoms improve.
Patient information leaflet
Generic Name: sulfametopyrazine
Pronounced: suhl-fuh-met-oh-PIR-uh-zeen
Why do we use sulfametopyrazine?
Sulfametopyrazine treats various bacterial infections like UTIs, respiratory, and GI infections by targeting specific bacterial pathways.
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