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Brand Name :
Negaban
Synonyms :
temocillin
Class :
Anti-Bacterial Agents Anti-infective Agents
Brand Name :
Negaban
Synonyms :
temocillin
Class :
Anti-Bacterial Agents Anti-infective Agents
Dosage forms and strengths Â
Reconstituted solution, injection (as sodium)Â
1 gramÂ
4 grams daily given intramuscular or intravenous injection in two divided doses
in critical cases, may increase to 6 grams daily in three divided doses 2 grams given as intravenous infusion for loading dose; in critical cases, 4- 6 grams daily is given
Not indicatedÂ
Refer adult dosingÂ
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
may diminish the serum concentration when combined with aminoglycosides
neomycin/polymyxin B/bacitracin topical
may diminish the serum concentration when combined with aminoglycosides
may diminish the serum concentration when combined with aminoglycosides
may diminish the serum concentration when combined with aminoglycosides
may diminish the serum concentration when combined with aminoglycosides
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
may increase the anticoagulant effect when combined with vitamin k antagonists
Co-administration of temocillin and willow bark may lead to increased levels of both drugs by affecting renal clearance
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
probenecid may increase the serum concentration of penicillins
acemetacin: they may enhance the serum concentration of penicillins
When temocillin is used together with ambroxol, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with articaine, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with benzocaine, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with bupivacaine, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with capsaicin, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with chloroprocaine, this leads to increased risk or seriousness of methemoglobinemia
When temocillin is used together with cinchocaine, this leads to increased risk or seriousness of methemoglobinemia
bismuth subcitrate, metronidazole and tetracycline
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
may decrease the therapeutic effect when combined with penicillins
Actions and Spectrum:Â
Action:Â Â
temocillin is a beta-lactam antibiotic that exerts its action by inhibiting bacterial cell wall synthesis. Specifically, it is a member of the penicillin class of antibiotics. Its mechanism of action involves binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, which are enzymes responsible for the cross-linking of peptidoglycan chains in the cell wall. By binding to PBPs, temocillin disrupts the formation of a stable cell wall, weakening the bacterial cell structure. This ultimately results in cell lysis and the death of the bacterial organism.Â
Spectrum:Â
temocillin is a narrow-spectrum antibiotic; it is effective against a limited range of bacterial species. It is primarily active against Gram-negative bacteria. temocillin is especially useful in targeting bacteria that produce beta-lactamases, which are enzymes that can inactivate many other penicillin antibiotics. It is often used to combat infections caused by multidrug-resistant Gram-negative bacteria.Â
Frequency not defined Â
VomitingÂ
NauseaÂ
Skin reactionsÂ
Black Box Warning:Â Â
None
Contraindication/Caution:Â Â
Hypersensitivity: Individuals with a known hypersensitivity or allergy to temocillin or other beta-lactam antibiotics (e.g., penicillins and cephalosporins) should not use temocillin.Â
Severe Allergic Reactions: Patients who have experienced severe allergic reactions (e.g., anaphylaxis) to beta-lactam antibiotics in the past should avoid temocillin.Â
Renal Impairment: temocillin is primarily eliminated by the kidneys. People who have significant renal impairment might necessitate modifications in their dosage or should avoid temocillin due to the risk of drug accumulation.Â
Pregnancy and Breastfeeding: The safety of temocillin during pregnancy and breastfeeding is not well-established. It is advisable to employ this treatment during pregnancy or breastfeeding solely when the potential advantages outweigh the possible risks, and this should be done under the supervision of a qualified healthcare provider.Â
Pregnancy warnings:    Â
Pregnancy category: N/AÂ
Lactation: Excreted into human milk is unknownÂ
Pregnancy Categories:        Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category
Pharmacology: temocillin is an antibiotic medication used to treat various bacterial infections.Â
Pharmacodynamics:Â
Inhibition of Bacterial Cell Wall Synthesis: temocillin exerts its antibacterial effect by inhibiting bacterial cell wall synthesis. It achieves this by binding to penicillin-binding proteins (PBPs) within the bacterial cell, which are enzymes involved in cross-linking peptidoglycan chains in the cell wall. This interference weakens the cell wall structure, leading to bacterial cell lysis and death. Â
Pharmacokinetics:Â
AbsorptionÂ
temocillin is administered intravenously. It is typically well-absorbed after IV administration, achieving therapeutic concentrations in the blood relatively quickly.Â
DistributionÂ
temocillin is distributed throughout the body’s tissues and fluids, including the lungs, skin, and other organs. It may cross the placenta, but the extent is limited.Â
MetabolismÂ
temocillin is not significantly metabolized in the body. Its primary elimination route is through unchanged excretion in the urinary system.Â
Excretion and EliminationÂ
The primary route of elimination for temocillin is via the kidneys, primarily through glomerular filtration and tubular secretion. The drug has a relatively short half-life, typically less than one hour.Â
Administration: Â
temocillin is typically administered intravenously (IV) or intramuscularly (IM) by a healthcare professional. It is not usually taken orally.Â
Patient information leafletÂ
Generic Name: temocillinÂ
Why do we use temocillin?Â
temocillin can be prescribed to treat urinary tract infections, including cystitis and pyelonephritis, caused by susceptible bacteria.Â
It can treat respiratory tract infections, such as pneumonia, bronchitis, and lung abscesses, when the responsible pathogens are susceptible to temocillin. temocillin may be utilized to manage skin and soft tissue infections caused by susceptible bacteria, including cellulitis and wound infections.Â
temocillin can sometimes be employed to treat intra-abdominal infections like peritonitis when the causative organisms are sensitive to this antibiotic.Â
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