Alcohol Consumption Emerges as a Key Risk Factor for Buccal Cancer in India
December 24, 2025
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Brand Name :
Ticar
Synonyms :
Carboxypenicillin
Class :
Brand Name :
Ticar
Synonyms :
Carboxypenicillin
Class :
Dosage forms with strengths:
Ticarcillin is given by IV and IM route. Ticarcillin is not absorbed orally.
Powder for injection: 1g, 3g, 3.1g, 2g
3g IV dose every 4 hours for approximately 14 days or until the absolute neutrophil count becomes greater than 500cells/mm3
The dose can be increased as per symptoms and intensity of infection
3g IV every 4 hours for 7 to 14 days, depending on the severity of the infection
3g IV every 4 hours for 3 to 4 weeks, depending on the severity of the infection
For prosthetic joint infections, longer therapy may be given of up to 6 weeks
3g IV every 4 hours for 4 to 6 weeks
For chronic osteomyelitis: 3g IV every 4 hours for 6 months with additional oral antimicrobial therapy
3g IV every 4 hours for 21 to 28 days, depending on the severity of the infection
3g IV every 4 to 6 hours continued for 10 to 14 days
For complicated: 3g IV every 4 to 6 hours continued for 10 to 14 days
For uncomplicated: 1g IM or IV every 6 hours
Dosage forms with strengths: Ticarcillin is given by IV and IM route. Ticarcillin is not absorbed orally.
Powder for injection: 1g, 3g, 3.1g, 2g
Dose for child ≤ 7 days:
Birthweight < 2 kg: 75mg/kg IV every 8 to 12 hours
Dose for child > 7 days:
Birthweight > 2 kg: 75mg/kg IV every 6 hours or 100mg/kg IV every 8 hours
Dose for 1 month to 12 years:
< 40 kg: 100 to 300mg/kg/day IV in equally doses every 4 to 6 hours
> 40 kg: 3g IV every 4 to 6 hours
Dose for child ≤ 7 days:
Birthweight < 2 kg: 75mg/kg IV every 12 hours
Dose for child > 7 days:
Birthweight > 2 kg: 75mg/kg IV every 6 hours or 100mg/kg IV every 8 hours
Dose for 1 month to 12 years:
< 40 kg: 100 to 300mg/kg/day IV in equally doses every 4 to 6 hours
> 40 kg: 3g IV every 4 to 6 hours
Dose for child ≤ 7 days:
Birthweight < 2 kg: 75mg/kg IV every 12 hours
Birthweight > 2 kg: 75mg/kg IV every 8 hours
Dose for child > 7 days:
Birthweight > 2 kg: 75mg/kg IV every 6 hours or 100mg/kg IV every 8 hours
For 1 month to 12 years:
< 40 kg: 100 to 300mg/kg/day IV in equally doses every 4 to 6 hours
> 40 kg: 3g IV every 4 to 6 hours
Uncomplicated infections in children of 1 month to 12 years:
< 40 kg: 50 to 100mg/kg/day IV or IM in equally doses every 6 to 8 hours
> 40 kg: 3g IV every 4 to 6 hours
Complicated infections in child of 1 month to 12 years:
< 40 kg: 150 to 200mg/kg/day IV in equally doses every 4 to 6 hours
> 40 kg: 3g IV every 4 to 6 hours
Causes Hypokalemia.
Increased level or effect of digoxin by affecting intestinal flora.
Decrease renal clearance.
Therapeutic effects of the BCG vaccine can be decreased when interacting with ticarcillin.
Avoid or use an alternative. Do not administer to patients who received parenteral antibiotics within 14 days of vaccination.
when both drugs are combined, there may be a reduced effect of ticarcillin
tetracycline may decrease the therapeutic effects of penicillins by interfering with its bactericidal effects
Increase systemic circulation of mycophenolate metabolites by hepatic reuptake.
Concomitant use of ticarcillin and willow bark may result in increased levels of both drugs due to decreased renal clearance
when both drugs are combined, there may be an increased risk of adverse effects
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
enhance the serum drug concentration by reducing renal clearance
probenecid may increase the serum concentration of penicillins
Increased serum concentration level by competitive plasma protein binding.
Increased serum concentration level by competitive plasma protein binding.
Increased serum concentration resulted from decreased renal clearance.
Actions and spectrum:
Ticarcillin works against bacteria by disrupting the formation of their cell walls. Peptidoglycan is a key component of bacterial cell walls. It helps maintain wall structure and rigidity. Ticarcillin blocks peptidoglycan cross-linking during cell wall synthesis. This weakens the cell wall. When bacteria begin dividing, their compromised cell walls rupture. Ultimately, the bacteria cannot survive with damaged cell walls, resulting in cell death.
Patients with a history of sensitivity to multiple allergens or hypersensitivity to beta-lactams may develop severe anaphylactoid reactions with ticarcillin therapy.
Black Box Warning
No specific black box warning is available
Contraindication/Caution:
Contraindication:
Hypersensitivity
Hypokalemia
Asthma history
Allergic reactions
Anaphylactic reactions to β-lactam antibiotics
Cautions:
Risk of neurotoxicity
Skin sensitization
Jarish- Herxheiner reactions especially in case of syphilis.
Heart failure
Pregnancy Categories:
Pharmacology:
Ticarcillin is an antibiotic. It treats bacterial infections. Ticarcillin belongs to the beta-lactam class of medications. Doctors prescribe it for many types of infections caused by bacteria. It is effective against a wide range of bacterial infections.
Pharmacodynamics:
Ticarcillin is an antibiotic. It works against many bacteria. Ticarcillin kills both gram-positive and gram-negative bacteria. It kills bacteria that need air and those that don’t. However, some bacteria make enzymes called ß-lactamases. These enzymes break down ticarcillin. So ticarcillin doesn’t work on bacteria that make these enzymes.
Pharmacokinetics:
Absorption
Ticarcillin has poor absorption from the intestines. But when injected into muscle, it reaches peak levels in blood within thirty to sixty minutes.
Distribution
About half of ticarcillin binds to proteins in blood. Its elimination half-life is typically seventy minutes for most people. For those with cystic fibrosis, the half-life is fifty minutes.
Metabolism:
Ticarcillin undergoes little metabolism in the body.
Excretion:
Around ninety percent is excreted unchanged in urine. It remains detectable for approximately one point one hours.
Administration:
To be administered as suggested by the doctor
Patient Information Leaflet:
Pronunciation: ti-car-cil-lin
Use: The antibiotic addresses numerous infections. It’s utilized for septicemia, breathing issues, musculoskeletal troubles, infections of integument, urinary disorders, intra-abdominal afflictions, gynecological maladies, and renal compromise.
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