DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Adverse drug reactions:  

Frequency Defined  

>10%  

Muscle cramping   

Somnolence   

Dyskinesia   

Nausea   

Insomnia   

Hallucinations   

Excessive dreaming   

Diarrhea   

Anorexia   

Dystonia  

Orthostatic hypotension   

Confusion   

Headache   

1-10%  

Constipation   

Upper respiratory tract infections  

Vomiting  

Pregnancy warnings:    

US FDA pregnancy category: C 

Breastfeeding warnings: 

The release of the drug into the human breastmilk is unknown  

Pregnancy Categories:      

• Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first trimester or the later trimester      
• Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women      
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women      
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits      
• Category X: Drugs listed in this category outweigh risks over benefits. Hence these categories of drugs need to be avoided by pregnant women      
• Category N: There is no data available for the drug under this category     

 

Patient Information Leaflet  

Generic Name: tolcapone 

Pronounciation: TOLE-ka-pone 

Why do we use tolcapone? 

tolcapone belongs to the class Anti-Parkinson Agent and COMT Inhibitor used to treat Parkinson’s disease. It increases the levels of levodopa in the body.