Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Rezulin, Noscal, Romozin
Synonyms :
troglitazone
Class :
Antidiabetic& thiazolidinedione
Brand Name :
Rezulin, Noscal, Romozin
Synonyms :
troglitazone
Class :
Antidiabetic& thiazolidinedione
Dosage Forms & StrengthsÂ
TabletsÂ
200mgÂ
300mgÂ
400mgÂ
Initial Dose:
200
mg
Tablet
Orally 
once a day
Data not available
Refer to adult dosing
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
may have an increased hypoglycemic effect when combined with sulfonylureas
the chances of hypoglycemia are high when acarbose is taken with troglitazone
metabolism of acetaminophen can be reduced wen taken with troglitazone
belzutifan when taken with troglitazone may cause adverse effects as its concentration in blood may increase
the effect of troglitazone may be enhanced when taken with ciprofloxacin
my increase the hypoglycemic effect of Sulfonylureas
serum levels of ofloxacin may be raised when combined with troglitazone
may decrease the therapeutic effect
when combined with troglitazone, the excretion of cholecystokinin may be decreased
Actions and spectrum:Â
It belongs to a diabetic class of drugs known as thiazolidinediones. It lowers blood sugar by improving the body’s sensitivity to insulin. Troglitazone works uniquely by relying on insulin’s presence to become activated. It lowers the glucose production in the liver and increases glucose uptake in muscles when insulin is present. The troglitazone interacts with protein receptors (PPARs) in the cell nuclei which controls the genes involved in regulating glucose and fat metabolism.Â
Frequency not defined
Nausea
Vomiting
Pain in abdomen
Laziness
Hepatic failure
Headache
Tachycardia
Weakness
Dizziness
Black Box WarningÂ
It has been removed from U.S market due its fatal effects on liver.Â
Contraindication/Caution:Â
Contraindication:Â
It is known to cause liver diseases leading to liver death.Â
AnorexiaÂ
HypersensitivityÂ
Caution:Â
It may lower the activity of birth control medication.Â
Pregnancy consideration:
US FDA pregnancy category: B
Lactation:
No sufficient study data
Pregnancy category:
Category A:Â Studies that were well-controlled and met expectations revealed no risk to the foetus `in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C:Â there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D:Â adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X:Â Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N:Â There is no data available for the drug under this category
PharmacologyÂ
It is a diabetes medication taken orally that improves blood sugar levels by reducing the body’s resistance to insulin.Â
PharmacodynamicsÂ
It is a diabetes medication taken orally that improves blood sugar levels by reducing the body’s resistance to insulin. It is combined with sulfonylureas or insulin to enhance blood sugar control.Â
Pharmacokinetics:Â
AbsorptionÂ
It is absorbed rapidly in the g.i.t and its absorption may be increased with by food to the extent of 30-85%Â
DistributionÂ
99% of troglitazone is bound to serum albumin.Â
MetabolismÂ
It undergoes in liver forming two important metabolites such as sulfate conjugate metabolite and quinone metabolite.Â
Elimination and excretionÂ
Majorly 85% of the drug is eliminated through faeces and 3% of the drug is eliminated in urine.Â
The elimination half-life is 16-34hours.Â
AdministrationÂ
It is administered orally in the form of tablets.Â
Patient information leafletÂ
Generic Name: troglitazoneÂ
Why do we use troglitazone?Â
It is used in the treatment of Diabetes mellitus (Type II).Â
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