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Brand Name :
Visudyne
Synonyms :
Verteporfin
Class :
Macular Degeneration Agents
Brand Name :
Visudyne
Synonyms :
Verteporfin
Class :
Macular Degeneration Agents
Dosage Forms & Strengths
lyophilized power for reconstitution
15mg/vial
Not determined
verteporfin: they may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents
verteporfin: they may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents
verteporfin: they may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents
verteporfin: they may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents
verteporfin: they may increase the serum concentration of Nonsteroidal Anti-Inflammatory Agents
methyl aminolevulinate topical
photosensitizing agents increase the effect of verteporfin
photosensitizing agents increase the effect of verteporfin
photosensitizing agents increase the effect of verteporfin
verteporfin: they may increase the antiplatelet effect of Agents with antiplatelet agentss
verteporfin: they may increase the antiplatelet effect of Agents with antiplatelet agentss
verteporfin: they may increase the antiplatelet effect of Agents with antiplatelet agentss
verteporfin: they may increase the antiplatelet effect of Agents with antiplatelet agentss
verteporfin: they may increase the antiplatelet effect of Agents with antiplatelet agentss
verteporfin: they may enhance the serum concentration of CYP2D6 Inhibitors
verteporfin: they may enhance the serum concentration of CYP2D6 Inhibitors
verteporfin: they may enhance the serum concentration of CYP2D6 Inhibitors
verteporfin: they may enhance the serum concentration of CYP2D6 Inhibitors
verteporfin: they may enhance the serum concentration of CYP2D6 Inhibitors
when both drugs are combined, there may be an increased risk of photosensitivity reactions
photosensitizing agents increase the effect of photosensitization of verteporfin
Pirfenidone may increase the photosensitizing effect of verteporfin
may increase the photosensitizing effect
may increase the photosensitizing effect when combined
adapalene and benzoyl peroxide
may increase the photosensitizing effect of photosensitizing agents
may increase the photosensitizing effect of Photosensitizing Agents
may increase the photosensitizing effect of Photosensitizing Agents
amiodarone: they may enhance the serum concentration of verteporfin
demeclocycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
doxycycline may reduce the therapeutic effect of the other drug by affecting intestinal flora
photosensitizing agents increase the effect of verteporfin
Action and Spectrum:
Plasma transports verteporfin mainly with lipoproteins. When activated it produces reactive singlet oxygen and radicals, that cause damage to neovascular endothelium and vessel occlusion.
Frequency not defined
Flashes of light
Severe vision loss
Photosensitivity
Visual disturbances
Edema
Hemorrhage
Inflammation
Headache
Conjunctivitis
Fever
Flu-like syndrome
Atrial fibrillation
Dry eyes
Ocular itching
Subconjunctival
Back pain during infusion
Asthenia
Peripheral vascular disorder
GI cancers
Nausea
Black box warning:
None
Contraindications/caution:
Contraindications:
Hypersensitivity
Porphyria
Cautions:
In pregnancy and lactation
Concurrent medications
Cardiovascular events
Pregnancy Warnings:
Pregnancy category: N/A
Lactation: Excretion of the drug into the human breast milk is known
Pregnancy categories:
Pharmacology: Verteporfin generates reactive oxygen species under specific light, that causes harm to cells and vessels. It targets abnormal retinal blood vessels linked to specific eye diseases effectively.
Pharmacodynamics: Verteporfin injected intravenously to target abnormal blood vessels in neovascular AMD, and it reacts with light at 689 nm wavelength.
Pharmacokinetic:
Excretion and elimination:
It is excreted through feces and shows half-life of 30 hours.
Administration:
It is available in powder (lyophilized) form for intravenous use.
Patient information leaflet:
Generic Name: Verteporfin
Why do we use Verteporfin?
Verteporfin is used in treatment of macular degeneration, pathologic myopia, and ocular histoplasmosis.
It is used in treatment of macular degeneration with choroidal neovascularization.
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