Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Brand Name :
Zopiclone, Zeclone, Zonap, Zopiclam, Zopium, Ziclone, DD Clone, Jpran
Synonyms :
zopiclone
Class :
Hypnotics and Non-benzodiazepine benzodiazepine agonist
Dosage Forms & Strengths
Tablet, Oral:
5 mg
7.5 mg
3.75 mg
7.5
mg/day
Orally 
at bedtime
4
weeks
Reduce the dose up to 3.75 mg according to the patient’s response
Dose Adjustments
Renal and hepatic impairment:
Reduce the dose to 3.75 mg
Discontinue the drug for severe failure
7.5
mg/day
Orally 
at bedtime
4
weeks
Reduce the dose up to 3.75 mg according to the patient’s response
Dose Adjustments
Renal and hepatic impairment:
Reduce the dose to 3.75 mg
Discontinue the drug for severe failure
Initiate at 3.75 mg/day orally at bedtime up to 4 weeks, increase gradually based on patient tolerance and clinical symptoms
Dose Adjustments
Renal and hepatic impairment:
Reduce the dose to 3.75 mg
Discontinue the drug for severe failure
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
Concomitant administration with benzodiazepine agonists may enhance the risk of extreme sedation, respiratory depression, and coma
may enhance the serum concentration of CYP3A4 inhibitors
CYP3A strong enhancers of the small intestine may reduce the bioavailability of zopiclone 
it increases the effect of CNS depressants
CNS depressants increase the effect of flunarizine
may increase the serum concentration of zopiclone
may increase the serum concentration of zopiclone
may increase the serum concentration of zopiclone
may increase the serum concentration of zopiclone
may increase the serum concentration of zopiclone
CYP3A4 Inhibitors (Moderate) may increase the serum concentration when combined with Zopiclone
zopiclone: they may diminish the serum concentration of CYP3A4 Inducers
zopiclone: they may diminish the serum concentration of CYP3A4 Inducers
zopiclone: they may diminish the serum concentration of CYP3A4 Inducers
zopiclone: they may diminish the serum concentration of CYP3A4 Inducers
zopiclone: they may diminish the serum concentration of CYP3A4 Inducers
CYP3A4 inhibitors increase the concentration of zopiclone in serum
may increase the CNS depressant effect
the metabolism of asunaprevir can be diminished when combined with zopiclone
when combined with ivacaftor, there can be an increase in the serum concentration of zopiclone
the risk of adverse effects may be increased
the risk of adverse effects will be increased when zopiclone is taken with zotepine
Frequency defined:
>10% (significant)
Restlessness
Aggression
Bizarre
Behavior
Agitation
Hallucinations
Depersonalization
Rebound insomnia
Anterograde amnesia
Suicidal ideation
Drug dependence
1% to 5%
Angioedema
Dysgeusia
Dry mouth
Nausea
Vomiting
Fatigue
Dizziness
Headache
Pregnancy consideration: Studies reported major congenital malformations following in-utero exposure to zopiclone.
Lactation: Zopiclone can be excreted in breast milk, unsafe to use during lactation.
Â
Pregnancy category:
Patient information leaflet
Generic Name: Zopiclone
Pronounced: zopiclone
Why do we use zopiclone?
Zopiclone is used to treat trouble sleeping and insomnia.