Fame and Mortality: Evidence from a Retrospective Analysis of Singers
November 26, 2025
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Brand Name :
Excedrin Tension Headache
(United States) [Available]Synonyms :
acetaminophen and caffeine
Class :
Analgesics, Other Combos
Brand Name :
Excedrin Tension Headache
(United States) [Available]Synonyms :
acetaminophen and caffeine
Class :
Analgesics, Other Combos
Dosage forms & Strengths:
Adult:
Tablet
500 mg/65 mg
Caplet
500 mg/65 mg
Gel Tab
500 mg/65 mg
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may enhace the serum concentration of each other when it is combined
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect of immune checkpoint inhibitors
may reduce the therapeutic effect
may reduce the therapeutic effect
may reduce the therapeutic effect
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
may increase the levels of serum concentration
an increase in CNS depression may be seen
cinnarizine and dimenhydrinateÂ
this combination will make you feel sleepy or tired when Analgesics used in combination
Actions and Spectrum:
acetaminophen inhibits the production of prostaglandins in the CNS and blocks the generation of the peripheral pain impulse.
caffeine has vasoconstrictive properties that are beneficial for the vascular headaches.
Urticaria
Angioedema
Laryngeal edema
Leukopenia
Neutropenia
Pancytopenia
Agranulocytosis
Thrombocytopenia
Hepatotoxicity
Anaphylactoid reaction
Restlessness
Insomnia
Tinnitus
Tremor
Nausea
Irritability
Tachycardia
Diarrhea
Diuresis
Nervousness
Black Box Warning:
It is essential to follow the dosage and administration instructions for the medication carefully.
Contraindications:
Allergic reactions to the drug
Active liver disease or a history of liver problems
Alcoholic liver disease
Caution:
Excessive use can lead to liver damage. Do not exceed the daily dose
Chronic use may also increase the risk of kidney damage
Patients with heavy alcohol usage or liver disease should use caution when taking acetaminophen
Pregnancy consideration:
Overdose of the drug is not safe during pregnancy.
Breastfeeding warnings:
Use the drug with caution during breastfeeding
Pregnancy category:
Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
acetaminophen works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation in the body. caffeine is a CNS stimulant that blocks the action of adenosine, a chemical that causes drowsiness and slows down nerve cell activity.
When combined, acetaminophen and caffeine can have a synergetic effect in reducing pain and increasing alertness. caffeine can also enhance the absorption and effectiveness of acetaminophen. The combination is commonly used to treat headaches, menstrual cramps, and other types of pain.
Pharmacodynamics:
Not available
Pharmacokinetics:
Not available
Administration:
Administer the medication orally as a tablet.
Patient information leaflet
Generic Name: acetaminophen and caffeine
Pronounced: uh-see-tuh-min-uh-fuh n. acet-aminophen
Why do we use acetaminophen and caffeine?
It is a combination of analgesic drugs used to treat analgesia.
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