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Brand Name :
Cefadroxil sandoz
(France) [Available]Synonyms :
cefadroxil
Class :
Cephalosporins 1st Generation
Brand Name :
Cefadroxil sandoz
(France) [Available]Synonyms :
cefadroxil
Class :
Cephalosporins 1st Generation
Dosage Forms & Strengths
Capsule
500mg
Oral suspension
250mg /5ml
500mg/ 5ml
Tablet
1g
1
g
Orally
once a day
or can be provided in divided doses twice a day
The maximum duration of treatment in beta-hemolytic streptococcal infections is ten days.
Indicated for mild/moderate lower urinary tract infections like cystitis:
1 - 2
g
Orally
once a day
or can be provided in divided doses twice a day
severe urinary tract infections: 1 gram orally given in divided doses twice a day
Indicated for mild/moderate lower urinary tract infections like cystitis:
1 - 2
g
Orally
once a day
or can be provided in divided doses twice a day
severe urinary tract infections: 1 gram orally given in divided doses twice a day
Indicated for mild/moderate lower urinary tract infections like cystitis:
1 - 2
g
Orally
once a day
1-2 grams given orally per day or can be provided in divided doses twice a day
severe urinary tract infections: 1 gram orally given in divided doses twice a day
mild/moderate:
1 - 2
g
Orally
once a day
or can be provided in divided doses twice a day
severe: 1 g orally given in divided doses twice a day
Group A Streptococcal (GAS) Infections
1
g
orally
daily
10
days
Note: indicated for pharyngitis and tonsillitis caused by Group A beta-hemolytic streptococci
Dosage forms and strengths
Capsule
500mg
Oral suspension
250mg/5ml
500mg/5ml
Tablet
1g
Children: 15 mg per kg orally given every 12hrs
The maximum duration of the treatment in beta-hemolytic streptococcal infections is ten days
Children: 15 mg per kg orally given every 12hrs
The maximum duration of the treatment in beta-hemolytic streptococcal infections is ten days
Children: 30 mg per kg orally per day or in divided doses twice a day
The maximum duration of the treatment in beta-hemolytic streptococcal infections is ten days
Group A Streptococcal (GAS) Infections
30
mg/kg
orally
daily
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
when both drugs are combined, there may be a decreased therapeutic effect of the vaccine
bazedoxifene conjugated estrogens
when both drugs are combined, there may be a decreased effect of bazedoxifene/conjugated estrogens by altering intestinal flora
when both drugs are combined, there may be a decreased effect of conjugated estrogens by altering intestinal flora
when both drugs are combined, there may be an increased effect of digoxin by altering intestinal flora
when both drugs are combined, there may be a decreased effect of estradiol by altering intestinal flora
when both drugs are combined, there may be a decreased effect of ethinylestradiol by altering intestinal flora
when both drugs are combined, there may be a decreased effect of mestranol by altering intestinal flora
when both drugs are combined, there may be an increased effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be a decreased effect of probenecid by acidic drug competition for renal tubular clearance
It may diminish the excretion when combined with dexamethasone
it may diminish the excretion rate when combined with estradiol valerate resulting in a greater serum level
cefadroxil has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When loracarbef is used together with cefadroxil, the risk or seriousness of nephrotoxicity is enhanced
When Cefadroxil is used together with piroxicam, this leads to increased risk or seriousness of nephrotoxicity
When cefmenoxime is used together with cefadroxil, this leads to enhanced risk or seriousness of nephrotoxicity
cefadroxil leads to a reduction in the rate of excretion of eucalyptus oil which leads to increased level of serum
cefadroxil leads to a reduction in the rate of excretion of chromous sulfate, which leads to an increased level of serum
cefadroxil leads to a reduction in the rate of excretion of pentaerythritol tetranitrate, which leads to an increased level of serum
the risk or severity of nephrotoxicity and hypocalcemia can increase when cefadroxil is combined with alendronic acid
cefadroxil leads to a reduction in the rate of excretion of potassium acetate, which leads to an increased level of serum
cefadroxil leads to a reduction in the rate of excretion of potassium perchlorate, which leads to an increased level of serum
cefadroxil leads to a reduction in the rate of excretion of nitric oxide, which leads to an increased level of serum
When cefadroxil is used together with difenpiramide, this leads to enhanced risk or seriousness of nephrotoxicity
cefadroxil may decrease the excretion rate of almasilate, leading to higher serum levels
it increases the concentration of cephalosporins in the serum
an increase in the severity of nephrotoxicity can be seen when cefadroxil is taken with kebuzone
may have a decrease in excretion when combined with cefadroxil
cefadroxil might lead to a reduction in the rate of excretion of telavancin, potentially leading to elevated levels of serum
when both drugs are combined, there may be an increased effect of aceclofenac by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of acemetacin by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of methyclothiazide by acidic (anionic) drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of metolazone by acidic drug competition for renal tubular clearance
when both drugs are combined, there may be an increased effect of nabumetone by acidic drug competition for renal tubular clearance
Action and spectrum:
Action:
Cefadroxil, a cephalosporin antibiotic, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), causing cell lysis and bacterial death.
Spectrum:
Cefadroxil is effective against Gram-positive and some Gram-negative bacteria.
Frequency defined
1-10%
Diarrhea
<1%
Abdominal pain
Anaphylaxis
Dyspepsia
Transaminases increased
Neutropenia
Pseudomembranous colitis
Nausea
Vomiting
Urticaria
Stevens-Johnson syndrome
Black box warning
Exercise caution if you have gastrointestinal conditions, especially colitis, as it might trigger ‘Clostridium difficile associated diarrhea (CDAD).
Contraindication/Caution:
Contraindications
Cautions
Pregnancy warnings:
US FDA pregnancy category: B
Breastfeeding warnings:
The release of the drug into the human breastmilk is known
Caution is recommended
Pregnancy Categories:
Pharmacology:
Cefadroxil is first generation cephalosporins used for various bacterial infections.
Pharmacodynamics:
Cefadroxil disrupts bacterial cell wall synthesis by targeting penicillin-binding proteins, causing cell lysis and death, particularly effective against gram-positive bacteria like Staphylococcus and Streptococcus.
Pharmacokinetics:
Absorption
Rapid absorption
The time to achieve peak effect is 70-90 minutes
Distribution
Protein-bound is 20%
The volume of distribution is 0.31 L/kg
Metabolism
The metabolism occurs in liver.
Elimination and Excretion
The drug has a half-life of 1-2 hours, extending to 20-24 hours in cases of renal impairment, and it’s excreted mainly through urine, (90%).
Administration:
Cefadroxil is available in capsule, tablet, and liquid forms for oral administration
Patient Information Leaflet
Generic Name: cefadroxil (Rx)
Pronounced: ce–fadrox-il
Why do we use cefadroxil?
The cephalosporin antibiotic cefadroxil is used to treat a variety of bacterial infections, including tonsillitis, skin and skin structure infections, and urinary tract infections.
S. pneumoniae, H. influenzae, staphylococci, S. pyogenes, and E. coli are among the bacteria that can cause skin, urinary tract infections, and ENT infections.
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