Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
Leukeran
(United States) [Available]Synonyms :
chlorambucil
Class :
Alkylating agent
Brand Name :
Leukeran
(United States) [Available]Synonyms :
chlorambucil
Class :
Alkylating agent
Dosage forms and strengths
Tablet (oral)
2 mg
5 mg
Chronic Lymphocytic Leukemia (Cll)
A dose of 4 to 10 mg or 0.1-0.2 mg per kg given orally as a single dose per day for 3-6 weeks
Hodgkin's disease 0.2 mg per kg per day is recommended
Other lymphomas or chronic lymphocytic leukemia 0.1 mg per kg per day is recommended
A dose of 4 to 10 mg or 0.1-0.2 mg per kg given orally as a single dose per day for 3-6 weeks
Hodgkin's disease 0.2 mg per kg per day is recommended
Other lymphomas or chronic lymphocytic leukemia 0.1 mg per kg per day is recommended
Dosage forms and strengths
Tablet (oral)
2 mg
5 mg
Chronic Lymphocytic Leukemia (Cll)
The drug dosage is not recommended to the children < 17 years, but if the condition of lymphoma or Hodgkin’s lymphoma is present in the children the adult dosage is followed
The drug dosage is not recommended to the children < 17 years, but if the condition of lymphoma or Hodgkin’s lymphoma is present in the children the adult dosage is followed
Dosage forms and strengths
Tablet (oral)
2 mg
5 mg
Age: >65 years
The renal function in patients above 65 years old may not work properly. Hence the dose adjustments will be done for these patients.
edoxaban: it may enhance the toxic effect of Anti-Inflammatory Agents
caplacizumab: it may enhance the toxic effect of Anti-Inflammatory Agents
By immunosuppressive effects, the effects of the other drug increase and results in risk of infection.
By immunosuppressive effects, the effects of the other drug increase and results in risk of infection.
By immunosuppressive effects, the effects of the other drug increases and results in risk of infection.
By immunosuppressive effects, the effects of the other drug increases and results in risk of infection.
When chlorambucil combines with palifermin, the toxicity of palifermin increases.
By immunosuppressive effects, the toxicity of the other drug increases and results in risk of infection.
By immunosuppressive effects, the toxicity of the other drug increases and results in risk of infection.
may enhance the risk of adverse effects when combined with clobetasol propionate
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
may decrease the therapeutic effect of immunosuppressants
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By immunosuppressive effects, the effect of vaccine activity decreases and results in risk of infection.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By immunosuppressive effects, the effect of vaccine activity decreases and results in risk of infection.
By synergism effects, the toxicity of the other drug increases.
By immunosuppressive effects, the toxicity of the other drug increases and results in risk of infection.
By synergism effects, the toxicity of the other drug increases.
By synergism effects, the toxicity of the other drug increases.
By immunosuppressive effects, the toxicity of the other drug increases and results in risk of infection.
By synergism effects, the toxicity of the other drug increases.
By immunosuppressive effects, the toxicity of the other drug increases and results in risk of infection.
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
It may enhance the risk of adverse effects when combined with Respiratory tract infections
When mometasone furoate is used together with chlorambucil, this leads to enhanced risk or seriousness of adverse outcomes
When chlorambucil is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
chlorambucil pharmacodynamically antagonistically reduces the effects of the influenza A (H5N1) vaccine
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
may increase the risk of adverse effects
both drug toxicity increases by synergism action
Involves higher risk of bone marrow suppression
when both drugs are combined, there may be an increased risk or severity of adverse effects
when thiotepa and chlorambucil combine, the toxicity of both drugs increases by synergism
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be an increased risk or severity of adverse effects
abiraterone acetate and niraparib
may decrease the therapeutic effect of immunosuppressive Agents
the activity of the anthrax vaccine can be reduced when used in combination with chlorambucil
Antineoplastic agents will reduce the plasma concentrations of the antibiotics.
Antineoplastic agents will reduce the plasma concentrations of the antibiotics.
Antineoplastic agents will reduce the plasma concentrations of the antibiotics.
Antineoplastic agents will reduce the plasma concentrations of the antibiotics.
Antineoplastic agents will reduce the plasma concentrations of the antibiotics.
The chlorambucil efficacy is increased and toxicity decreased when it combines with vit E by synergism action.
Action and spectrum:
Action:
Chlorambucil is classified as an alkylating agent. This is achieved through alkylation of DNA in which alkylating agents form a link with the substance commonly known as alkyl group. This alkylation process leads to the formation of two DNA strands that are covalently bonded, which makes the DNA to be inaccessible for replication.
Blackbox warning
None
Frequency defined
>10%
Neutropenia
Anemia
Leukopenia
Thrombocytopenia
Frequency Not Defined
GI effects
Hallucinations
Hepatotoxicity
Hyperuricemia
Infertility
Leukemia
Myelosuppression
Nausea
Peripheral neuropathy
Pulmonary fibrosis
Rash
Seizures
Secondary malignancies
Stevens-Johnson Syndrome
Toxic epidermal necrosis
Type I hypersensitivity
Urticaria
Vomiting
Blackbox warning
None
Contraindication/Caution
Contraindication
Hypersensitivity
Severe Bone Marrow Depression
Active Infections
Caution
Secondary Malignancies
Pregnancy and Lactation
Hepatic and Renal Impairment
Pregnancy and Lactation:
Pregnancy:
US FDA, AU TGA Pregnancy Category: D
Lactation:
The excretion of drug into the breastmilk is unknown.
The data is also not available.
Pregnancy Categories:
Pharmacology:
Chlorambucil is a chemotherapy drug used primarily in the treatment of various hematologic malignancies.
Pharmacodynamics:
Chlorambucil has the mode of action which involves the formation of a complex with the DNA. It combines with the guanine bases of the DNA to cause cross linking of the DNA strands, improper pairing of the base and thus, the fragmentation of the DNA strands. This is because the DNA needs to be protected from uncoiling and separating which is a requirement for replication and the transcription process. Therefore, there are evidence such that chlorambucil cause cell cycle arrest at the G2 phase and effectively leads to apoptosis in proliferative cells.
Pharmacokinetics:
Absorption
The bioavailability of the drug is 70 to 80%.
The drug peak plasma time is 1 hour.
Distribution
The protein bound for drug is 99%.
The volume of distribution is 0.3 L/kg.
Metabolism
The drug is metabolised in the liver.
Excretion and Elimination
The half-life of the drug is 1.5 hour.
The excretion of the drug occurs through urine 20 to 60% of metabolites.
Administration:
Chlorambucil is available in oral tablet form.
Chlorambucil treatment can be administered orally at a dose that depends on the disease, which is being treated, the patient’s response to the medications, and their general health state.
Patient Information Leaflet
Generic name: chlorambucil
Pronunciation: KLOR-am-byoo–sil
Why do we use chlorambucil?
Chlorambucil are usually prescribed in the first instance in cases of CLL. This has been employed to manage different forms of NHL and HL for their efficacious effects. It works in a way that aids in slowing the rate of growth of cancer cells through the administration of chlorambucil.
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