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Brand Name :
Cimaglex
Synonyms :
cimicoxib
Class :
NSAIDS
Brand Name :
Cimaglex
Synonyms :
cimicoxib
Class :
NSAIDS
VETERINARY DOSING (Dogs)
Chewable tablets
8mg
30mg
80mg
Chronic osteoarthritis in dogs
2mg/kg orally one time a day for up to 6 months
the antihypertensive activity of acebutolol may be reduced
the rate of decrease of abacavir may be reduced
the risk of adverse effects may be increased
the risk of nephrotoxicity may be increased
the risk of hypertension may be increased
the rate of excretion of alprazolam may be reduced
the risk of hemorrhage and bleeding may be increased
the risk of hyperkalemia may be increased
the rate of excretion of ancestim may be reduced
the risk of hypertension may be increased
the rate of excretion of tropisetron may be reduced
the risk of hemorrhage or bleeding may be increased
the rate of excretion of verapamil may be reduced
the risk of gastrointestinal bleeding may be increased
the risk of hypertension may be increased
Actions and spectrum:
It works by inhibiting the enzyme (COX-2) cyclooxygenase-2, which further blocks the synthesis of prostaglandins.
Frequency not defined
Transient or mild vomiting
Diarrhea
Ulcers in stomach
For veterinary use only
Contraindication/Caution:
Contraindication:
Hypersensitivity
Breeding
Lactating
Pregnancy consideration:
Contraindicated as it may result in bleeding
Lactation:
Contraindicated for use in lactating dogs
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
Comicoxib is a COX-2 inhibitor
Pharmacodynamics:
It is used in the treatment of pain and inflammation in dogs
Pharmacokinetics:
Absorption
Absorbed rapidly followed by oral administration
Time for maximum concentration: 2.25± 1.24 hours
Peak concentration: 0.3918± 0.09021µg/ml
Area under the curve: 1.676± 0.4735 µg.hr /ml
Distribution
Oral bioavailability: 44.53 ± 10.26
Metabolism
Undergoes hepatic metabolism
Elimination and excretion
Primary metabolite, demethylated cimicoxib is excreted in feces and to a lesser level in urine. The glucuronide conjugate is eliminated through urine.
Half-life:
1.38± 0.24hours
Administration:
Chewable tablets of cimicoxib should be given to dogs after food.
Patient information leaflet
Generic Name: cimicoxib
Why do we use cimicoxib?
Cimicoxib is an inhibitor of cyclooxygenase enzyme-2. It is a non-steroidal anti-inflammatory drug used in managing pain and inflammation because of osteoarthritis and postoperative procedures in dogs.
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