Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
Brand Name :
Cimaglex
Synonyms :
cimicoxib
Class :
NSAIDS
VETERINARY DOSING (Dogs)Â
Chewable tabletsÂ
8mgÂ
30mgÂ
80mgÂ
Chronic osteoarthritis in dogsÂ
2mg/kg orally one time a day for up to 6 monthsÂ
the antihypertensive activity of acebutolol may be reduced
the rate of decrease of abacavir may be reduced
the risk of adverse effects may be increased
the risk of nephrotoxicity may be increased
the risk of hypertension may be increased
the rate of excretion of alprazolam may be reduced
the risk of hemorrhage and bleeding may be increased
the risk of hyperkalemia may be increased
the rate of excretion of ancestim may be reduced
the risk of hypertension may be increased
the rate of excretion of tropisetron may be reduced
the risk of hemorrhage or bleeding may be increased
the rate of excretion of verapamil may be reduced
the risk of gastrointestinal bleeding may be increased
the risk of hypertension may be increased
Actions and spectrum:Â
It works by inhibiting the enzyme (COX-2) cyclooxygenase-2, which further blocks the synthesis of prostaglandins.
Frequency not definedÂ
Transient or mild vomitingÂ
DiarrheaÂ
Ulcers in stomach
For veterinary use onlyÂ
Contraindication/Caution:Â
Contraindication:Â
Hypersensitivity Â
BreedingÂ
Lactating Â
Pregnancy consideration:Â Â
Contraindicated as it may result in bleedingÂ
Lactation:Â Â
Contraindicated for use in lactating dogsÂ
Pregnancy category:Â Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus `in either the first or second trimester.Â
Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.  Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.  Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this category Â
Pharmacology:Â
Comicoxib is a COX-2 inhibitorÂ
Pharmacodynamics:Â
It is used in the treatment of pain and inflammation in dogsÂ
Pharmacokinetics:Â
AbsorptionÂ
Absorbed rapidly followed by oral administrationÂ
Time for maximum concentration: 2.25± 1.24 hoursÂ
Peak concentration: 0.3918± 0.09021µg/mlÂ
Area under the curve: 1.676± 0.4735 µg.hr /mlÂ
DistributionÂ
Oral bioavailability: 44.53 ± 10.26Â
MetabolismÂ
Undergoes hepatic metabolism Â
Elimination and excretionÂ
Primary metabolite, demethylated cimicoxib is excreted in feces and to a lesser level in urine. The glucuronide conjugate is eliminated through urine.Â
Half-life:Â
1.38± 0.24hoursÂ
Administration:Â
Chewable tablets of cimicoxib should be given to dogs after food.Â
Patient information leafletÂ
Generic Name: cimicoxibÂ
Why do we use cimicoxib?Â
Cimicoxib is an inhibitor of cyclooxygenase enzyme-2. It is a non-steroidal anti-inflammatory drug used in managing pain and inflammation because of osteoarthritis and postoperative procedures in dogs.