clonixin

Action and Spectrum

Actions and Spectrum: 

Actions: 

Clonixin is categorized as an analgesic, non-steroidal anti-inflammatory medication (NSAID). It has been shown to suppress prostaglandin synthesis and block inward calcium currents. 

Spectrum: 

Clonixin therapy is indicated for the relief of headaches, joint pain, muscle aches, earaches, toothaches, and menstrual pain, as well as post-surgery, post-trauma, and gynecological discomfort. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Dizziness 

Nausea 

Somnolence 

Constipation 

Dry mouth 

Gastric perforation 

GI bleeding 

Peptic ulcer 

Mania 

Vomiting 

Sweating 

Black Box Warning

Black Box Warning: 

Clonixin primarily provides symptomatic relief, particularly in pain management, without addressing the underlying cause of the pain. Before integrating Clonixin into the treatment of chronic conditions, it is crucial to conduct clinical tests assessing blood count, kidney and liver function, and urine analysis. Regular monitoring of essential parameters is essential for timely detection of adverse effects and facilitating the prompt discontinuation of the drug.

When using clonixin as monotherapy for inflammation and pain associated with an infection, there is a chance of the infection spreading to other tissues; hence, concurrent use of appropriate antibiotics is necessary. Caution is advised when combining Clonixin with other anti-inflammatory drugs unless absolutely necessary. Similar to other systemic NSAIDs (excluding aspirin), clonixin use may increase the risk of cardiovascular thrombotic events, including myocardial infarction and stroke, potentially leading to fatality.

This risk escalates with higher doses and prolonged usage. Therefore, before prescribing Clonixin for extended periods, patients should undergo evaluation for the risk of cardiovascular events and receive regular monitoring during treatment. To minimize this risk, the lowest effective daily dose of clonixin should be employed for the shortest possible duration. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Pediatrics 

Cautions 

• Renal impairment 
• Peripheral vascular disease 
• Severe HTN 
• Coronary disease 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Classified as a non-steroidal agent, clonixin is a compound of aniline and nicotinic acid with structural similarities to flufenamic acid. Along with its modest gastrointestinal side effects, it has analgesic and antipyretic benefits. Clonixin’s mechanism of action is still poorly understood at the molecular level. However, it is thought to work similarly to other NSAIDs. This entails the suppression of both cyclooxygenase 1 and 2, which lowers the synthesis of prostaglandins. 

Pharmacodynamics: 

Clonixin is a member of the non-steroidal anti-inflammatory medication (NSAID) class and shares a structure similar to that of Diclofenac. It induces vasodilation and produces analgesic effects. 

Pharmacokinetics: 

Absorption 

The bioavailability is 75% 

The time to achieve peak effect is 15 minutes. 

Distribution 

The volume of distribution is 1.14 to 1.29 L in children where it is not effective. 

Metabolism 

Clonixin undergoes substantial hepatic metabolism, leading to the generation of hydroxylated and hydroxymethylated metabolites.  

Elimination and Excretion 

The half-life is 1.5 – 1.7 hours. 

Adminstartion

Administration: 

The application of clonixin entails adhering to prescribed protocols for its delivery. Commonly, it is orally administered in the form of tablets, capsules, or oral solutions. In certain situations, intravenous injection may be employed, especially within a healthcare environment.

The precise dosage, frequency, and method of administration vary based on the specific medical condition, individual patient factors, and recommendations from healthcare providers.

It is essential for patients to diligently adhere to the prescribed administration instructions and communicate any existing medical conditions, allergies, or concurrent medications to healthcare professionals, ensuring the secure and effective utilization of clonixin. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: clonixin 

Pronounced: kloh-niks-in 

Why do we use clonixin? 

As a non-steroidal anti-inflammatory medicine (NSAID) with analgesic qualities, clonixin is used to reduce inflammation and relieve pain in a number of different medical disorders. The main goals of using clonixin include:  

Pain Relief: Clonixin effectively relieves mild to moderate pain that is brought on by ailments like headaches, toothaches, muscle soreness, and menstrual cramps.  

Reduced Inflammation: Clonixin, an NSAID, reduces inflammation by preventing the body from producing prostaglandins, which are chemicals that cause pain and inflammation. Fever Reduction: Those suffering from fever-related ailments can also use clonixin to reduce their fever.